6r9r - Revision history

OCA at 12:17, 24 January 2024

OCA — Wed, 24 Jan 2024 12:17:48 GMT

←Older revision		Revision as of 12:17, 24 January 2024
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	<StructureSection load='6r9r' size='340' side='right'caption='[[6r9r]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='6r9r' size='340' side='right'caption='[[6r9r]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r9r]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Sulir Sulir~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6R9R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r9r]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_islandicus_REY15A Sulfolobus islandicus REY15A] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R9R FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6qzq\|6qzq]], [[6qzt\|6qzt]], [[6r7b\|6r7b]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">SiRe_0884 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=930945 SULIR])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9r OCA], [https://pdbe.org/6r9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r9r RCSB], [https://www.ebi.ac.uk/pdbsum/6r9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9r ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6r9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9r OCA], [~~http~~://pdbe.org/6r9r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6r9r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6r9r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9r ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F0NE21_SULIR F0NE21_SULIR]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Sulir~~]]	+	[[Category: Sulfolobus islandicus REY15A]]
-	[[Category: Molina, R]]	+	[[Category: Synthetic construct]]
-	[[Category: Montoya, G]]	+	[[Category: Molina R]]
-	[[Category: Sofos, N]]	+	[[Category: Montoya G]]
-	[[Category: Stella, S]]	+	[[Category: Sofos N]]
-	~~[[Category: Crispr associated protein carf hepn rnase]]~~	+	[[Category: Stella S]]
-	~~[[Category: Rna binding protein~~]]	+

OCA at 11:49, 13 November 2019

OCA — Wed, 13 Nov 2019 11:49:32 GMT

←Older revision		Revision as of 11:49, 13 November 2019
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	<StructureSection load='6r9r' size='340' side='right'caption='[[6r9r]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='6r9r' size='340' side='right'caption='[[6r9r]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r9r]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R9R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r9r]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulir Sulir]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R9R FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qzq\|6qzq]], [[6qzt\|6qzt]], [[6r7b\|6r7b]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qzq\|6qzq]], [[6qzt\|6qzt]], [[6r7b\|6r7b]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SiRe_0884 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=930945 SULIR])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9r OCA], [http://pdbe.org/6r9r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r9r RCSB], [http://www.ebi.ac.uk/pdbsum/6r9r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9r OCA], [http://pdbe.org/6r9r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r9r RCSB], [http://www.ebi.ac.uk/pdbsum/6r9r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9r ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Sulir]]
	[[Category: Molina, R]]		[[Category: Molina, R]]
	[[Category: Montoya, G]]		[[Category: Montoya, G]]

OCA at 10:39, 2 October 2019

OCA — Wed, 02 Oct 2019 10:39:37 GMT

←Older revision		Revision as of 10:39, 2 October 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6r9r is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Csx1 in complex with cyclic oligoadenylate cOA4 conformation 2==
		+	<StructureSection load='6r9r' size='340' side='right'caption='[[6r9r]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6r9r]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R9R FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qzq\|6qzq]], [[6qzt\|6qzt]], [[6r7b\|6r7b]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9r OCA], [http://pdbe.org/6r9r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r9r RCSB], [http://www.ebi.ac.uk/pdbsum/6r9r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9r ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Type III CRISPR-Cas multisubunit complexes cleave ssRNA and ssDNA. These activities promote the generation of cyclic oligoadenylate (cOA), which activates associated CRISPR-Cas RNases from the Csm/Csx families, triggering a massive RNA decay to provide immunity from genetic invaders. Here we present the structure of Sulfolobus islandicus (Sis) Csx1-cOA4 complex revealing the allosteric activation of its RNase activity. SisCsx1 is a hexamer built by a trimer of dimers. Each dimer forms a cOA4 binding site and a ssRNA catalytic pocket. cOA4 undergoes a conformational change upon binding in the second messenger binding site activating ssRNA degradation in the catalytic pockets. Activation is transmitted in an allosteric manner through an intermediate HTH domain, which joins the cOA4 and catalytic sites. The RNase functions in a sequential cooperative fashion, hydrolyzing phosphodiester bonds in 5'-C-C-3'. The degradation of cOA4 by Ring nucleases deactivates SisCsx1, suggesting that this enzyme could be employed in biotechnological applications.

-	~~Authors~~:	+	Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas.,Molina R, Stella S, Feng M, Sofos N, Jauniskis V, Pozdnyakova I, Lopez-Mendez B, She Q, Montoya G Nat Commun. 2019 Sep 20;10(1):4302. doi: 10.1038/s41467-019-12244-z. PMID:31541109<ref>PMID:31541109</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6r9r" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Molina, R]]
		+	[[Category: Montoya, G]]
		+	[[Category: Sofos, N]]
		+	[[Category: Stella, S]]
		+	[[Category: Crispr associated protein carf hepn rnase]]
		+	[[Category: Rna binding protein]]

OCA at 04:26, 3 July 2019

OCA — Wed, 03 Jul 2019 04:26:27 GMT

←Older revision		Revision as of 04:26, 3 July 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6r9r is ON HOLD	+	The entry 6r9r is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 05:23, 26 June 2019

OCA — Wed, 26 Jun 2019 05:23:24 GMT

←Older revision		Revision as of 05:23, 26 June 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6r9r is ON HOLD ~~until Paper Publication~~	+	The entry 6r9r is ON HOLD

	Authors:		Authors:

OCA at 04:20, 17 April 2019

OCA — Wed, 17 Apr 2019 04:20:28 GMT

←Older revision		Revision as of 04:20, 17 April 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6r9r is ON HOLD	+	The entry 6r9r is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6r9r" [edit=sysop:move=sysop]

OCA — Wed, 10 Apr 2019 05:47:20 GMT

Protected "6r9r" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:47, 10 April 2019

OCA: New page: '''Unreleased structure''' The entry 6r9r is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 10 Apr 2019 05:47:19 GMT

New page: '''Unreleased structure''' The entry 6r9r is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6r9r is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]