6r9t - Revision history

OCA at 10:10, 22 May 2024

OCA — Wed, 22 May 2024 10:10:01 GMT

←Older revision		Revision as of 10:10, 22 May 2024
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	<SX load='6r9t' size='340' side='right' viewer='molstar' caption='[[6r9t]], [[Resolution\|resolution]] 6.20Å' scene=''>		<SX load='6r9t' size='340' side='right' viewer='molstar' caption='[[6r9t]], [[Resolution\|resolution]] 6.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r9t]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6R9T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r9t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R9T FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~TLN1~~, ~~KIAA1027, TLN (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 6.2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6r9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9t OCA], [~~http~~://pdbe.org/6r9t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6r9t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6r9t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9t OCA], [https://pdbe.org/6r9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r9t RCSB], [https://www.ebi.ac.uk/pdbsum/6r9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TLN1_HUMAN TLN1_HUMAN]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).	+	[https://www.uniprot.org/uniprot/TLN1_HUMAN TLN1_HUMAN] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Talin\|Talin]]	+	*[[Talin 3D structures\|Talin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Biertumpfel, C]]	+	[[Category: Biertumpfel C]]
-	[[Category: Dedden, D]]	+	[[Category: Dedden D]]
-	[[Category: Mizuno, N]]	+	[[Category: Mizuno N]]
-	[[Category: Schumacher, S]]	+	[[Category: Schumacher S]]
-	[[Category: Zacharias, M]]	+	[[Category: Zacharias M]]
-	~~[[Category: Actin]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Focal adhesion]]~~	+
-	~~[[Category: Signaling]]~~	+
-	~~[[Category: Vinculin~~]]	+

OCA at 05:25, 11 April 2020

OCA — Sat, 11 Apr 2020 05:25:05 GMT

←Older revision		Revision as of 05:25, 11 April 2020
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	<SX load='6r9t' size='340' side='right' viewer='molstar' caption='[[6r9t]], [[Resolution\|resolution]] 6.20Å' scene=''>		<SX load='6r9t' size='340' side='right' viewer='molstar' caption='[[6r9t]], [[Resolution\|resolution]] 6.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r9t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9T OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6R9T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r9t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6R9T FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TLN1, KIAA1027, TLN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TLN1, KIAA1027, TLN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6r9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9t OCA], [http://pdbe.org/6r9t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r9t RCSB], [http://www.ebi.ac.uk/pdbsum/6r9t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6r9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9t OCA], [http://pdbe.org/6r9t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r9t RCSB], [http://www.ebi.ac.uk/pdbsum/6r9t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 00:08, 7 March 2020

OCA — Sat, 07 Mar 2020 00:08:05 GMT

←Older revision		Revision as of 00:08, 7 March 2020
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	==Cryo-EM structure of autoinhibited human talin-1==		==Cryo-EM structure of autoinhibited human talin-1==
-	<~~StructureSection~~ load='6r9t' size='340' side='right'caption='[[6r9t]], [[Resolution\|resolution]] 6.20Å' scene=''>	+	<SX load='6r9t' size='340' side='right' viewer='molstar' caption='[[6r9t]], [[Resolution\|resolution]] 6.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6r9t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R9T FirstGlance]. <br>		<table><tr><td colspan='2'>[[6r9t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R9T FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 6r9t" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6r9t" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Talin\|Talin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 12:52, 18 December 2019

OCA — Wed, 18 Dec 2019 12:52:10 GMT

←Older revision		Revision as of 12:52, 18 December 2019
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	<StructureSection load='6r9t' size='340' side='right'caption='[[6r9t]], [[Resolution\|resolution]] 6.20Å' scene=''>		<StructureSection load='6r9t' size='340' side='right'caption='[[6r9t]], [[Resolution\|resolution]] 6.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6r9t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R9T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6r9t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R9T FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9t OCA], [http://pdbe.org/6r9t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r9t RCSB], [http://www.ebi.ac.uk/pdbsum/6r9t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9t ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TLN1, KIAA1027, TLN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9t OCA], [http://pdbe.org/6r9t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r9t RCSB], [http://www.ebi.ac.uk/pdbsum/6r9t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Biertumpfel, C]]		[[Category: Biertumpfel, C]]

OCA at 05:59, 16 October 2019

OCA — Wed, 16 Oct 2019 05:59:57 GMT

←Older revision		Revision as of 05:59, 16 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6r9t is ~~ON HOLD until Paper~~ Publication	+	==Cryo-EM structure of autoinhibited human talin-1==
		+	<StructureSection load='6r9t' size='340' side='right'caption='[[6r9t]], [[Resolution\|resolution]] 6.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6r9t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R9T FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9t OCA], [http://pdbe.org/6r9t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r9t RCSB], [http://www.ebi.ac.uk/pdbsum/6r9t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9t ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TLN1_HUMAN TLN1_HUMAN]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Focal adhesions (FAs) are protein machineries essential for cell adhesion, migration, and differentiation. Talin is an integrin-activating and tension-sensing FA component directly connecting integrins in the plasma membrane with the actomyosin cytoskeleton. To understand how talin function is regulated, we determined a cryoelectron microscopy (cryo-EM) structure of full-length talin1 revealing a two-way mode of autoinhibition. The actin-binding rod domains fold into a 15-nm globular arrangement that is interlocked by the integrin-binding FERM head. In turn, the rod domains R9 and R12 shield access of the FERM domain to integrin and the phospholipid PIP2 at the membrane. This mechanism likely ensures synchronous inhibition of integrin, membrane, and cytoskeleton binding. We also demonstrate that compacted talin1 reversibly unfolds to an approximately 60-nm string-like conformation, revealing interaction sites for vinculin and actin. Our data explain how fast switching between active and inactive conformations of talin could regulate FA turnover, a process critical for cell adhesion and signaling.

-	~~Authors~~:	+	The Architecture of Talin1 Reveals an Autoinhibition Mechanism.,Dedden D, Schumacher S, Kelley CF, Zacharias M, Biertumpfel C, Fassler R, Mizuno N Cell. 2019 Sep 19;179(1):120-131.e13. doi: 10.1016/j.cell.2019.08.034. PMID:31539492<ref>PMID:31539492</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6r9t" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Biertumpfel, C]]
		+	[[Category: Dedden, D]]
		+	[[Category: Mizuno, N]]
		+	[[Category: Schumacher, S]]
		+	[[Category: Zacharias, M]]
		+	[[Category: Actin]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Focal adhesion]]
		+	[[Category: Signaling]]
		+	[[Category: Vinculin]]

OCA at 04:15, 21 August 2019

OCA — Wed, 21 Aug 2019 04:15:34 GMT

←Older revision		Revision as of 04:15, 21 August 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6r9t is ON HOLD	+	The entry 6r9t is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6r9t" [edit=sysop:move=sysop]

OCA — Wed, 10 Apr 2019 05:47:27 GMT

Protected "6r9t" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:47, 10 April 2019

OCA: New page: '''Unreleased structure''' The entry 6r9t is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 10 Apr 2019 05:47:25 GMT

New page: '''Unreleased structure''' The entry 6r9t is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6r9t is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]