OCA at 09:48, 18 November 2020

OCA — Wed, 18 Nov 2020 09:48:28 GMT

←Older revision		Revision as of 09:48, 18 November 2020
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-	==~~protein A~~ Mycoplasma pneumoniae==	+	==P1 Mycoplasma pneumoniae==
-	<StructureSection load='6rc9' size='340' side='right'caption='[[6rc9]]' scene=''>	+	<StructureSection load='6rc9' size='340' side='right'caption='[[6rc9]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RC9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RC9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycpn Mycpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RC9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RC9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rc9 OCA], [http://pdbe.org/6rc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rc9 RCSB], [http://www.ebi.ac.uk/pdbsum/6rc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rc9 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mgpA, MPN_141, MP013 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272634 MYCPN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rc9 OCA], [http://pdbe.org/6rc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rc9 RCSB], [http://www.ebi.ac.uk/pdbsum/6rc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rc9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ADP1_MYCPN ADP1_MYCPN]] The protein is the major adhesin mediating the attachment of this mycoplasma to respiratory epithelium.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mycoplasma pneumoniae is a bacterial human pathogen that causes primary atypical pneumonia. M. pneumoniae motility and infectivity are mediated by the immunodominant proteins P1 and P40/P90, which form a transmembrane adhesion complex. Here we report the structure of P1, determined by X-ray crystallography and cryo-electron microscopy, and the X-ray structure of P40/P90. Contrary to what had been suggested, the binding site for sialic acid was found in P40/P90 and not in P1. Genetic and clinical variability concentrates on the N-terminal domain surfaces of P1 and P40/P90. Polyclonal antibodies generated against the mostly conserved C-terminal domain of P1 inhibited adhesion of M. pneumoniae, and serology assays with sera from infected patients were positive when tested against this C-terminal domain. P40/P90 also showed strong reactivity against human infected sera. The architectural elements determined for P1 and P40/P90 open new possibilities in vaccine development against M. pneumoniae infections.
		+
		+	Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae.,Vizarraga D, Kawamoto A, Matsumoto U, Illanes R, Perez-Luque R, Martin J, Mazzolini R, Bierge P, Pich OQ, Espasa M, Sanfeliu I, Esperalba J, Fernandez-Huerta M, Scheffer MP, Pinyol J, Frangakis AS, Lluch-Senar M, Mori S, Shibayama K, Kenri T, Kato T, Namba K, Fita I, Miyata M, Aparicio D Nat Commun. 2020 Oct 14;11(1):5188. doi: 10.1038/s41467-020-18777-y. PMID:33057023<ref>PMID:33057023</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6rc9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aparicio D]]	+	[[Category: Mycpn]]
-	[[Category: Fita I]]	+	[[Category: Aparicio, D]]
-	[[Category: Illanes R]]	+	[[Category: Fita, I]]
-	[[Category: Vizarraga D]]	+	[[Category: Illanes, R]]
		+	[[Category: Vizarraga, D]]
		+	[[Category: Adhesin]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Extracellular]]
		+	[[Category: Immunodominant protein]]
		+	[[Category: Transmembrane-complex]]

OCA at 07:21, 4 November 2020

OCA — Wed, 04 Nov 2020 07:21:15 GMT

←Older revision		Revision as of 07:21, 4 November 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6rc9 is ~~ON HOLD until Paper Publication~~	+	==protein A Mycoplasma pneumoniae==
-		+	<StructureSection load='6rc9' size='340' side='right'caption='[[6rc9]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RC9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RC9 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rc9 OCA], [http://pdbe.org/6rc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rc9 RCSB], [http://www.ebi.ac.uk/pdbsum/6rc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rc9 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Aparicio D]]
		+	[[Category: Fita I]]
		+	[[Category: Illanes R]]
		+	[[Category: Vizarraga D]]

OCA at 13:31, 11 December 2019

OCA — Wed, 11 Dec 2019 13:31:46 GMT

←Older revision		Revision as of 13:31, 11 December 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6rc9 is ON HOLD	+	The entry 6rc9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6rc9" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2019 04:26:58 GMT

Protected "6rc9" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:26, 17 April 2019

OCA: New page: '''Unreleased structure''' The entry 6rc9 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 17 Apr 2019 04:26:56 GMT

New page: '''Unreleased structure''' The entry 6rc9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6rc9 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6rc9 - Revision history

OCA at 09:48, 18 November 2020

OCA at 07:21, 4 November 2020

OCA at 13:31, 11 December 2019

OCA: Protected "6rc9" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6rc9 is ON HOLD Authors: Description: Category: Unreleased Structures