6rcd - Revision history

OCA at 12:18, 24 January 2024

OCA — Wed, 24 Jan 2024 12:18:44 GMT

←Older revision		Revision as of 12:18, 24 January 2024
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	<StructureSection load='6rcd' size='340' side='right'caption='[[6rcd]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='6rcd' size='340' side='right'caption='[[6rcd]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rcd]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_33530 Atcc 33530~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RCD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6RCD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rcd]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasma_genitalium Mycoplasma genitalium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RCD FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6rcc\|6rcc]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">mgpB, MG191 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=2097 ATCC 33530])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rcd OCA], [https://pdbe.org/6rcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rcd RCSB], [https://www.ebi.ac.uk/pdbsum/6rcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rcd ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6rcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rcd OCA], [~~http~~://pdbe.org/6rcd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rcd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rcd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rcd ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ADP1_MYCGE ADP1_MYCGE] The protein is the major adhesin mediating the attachment of this mycoplasma to the ciliated epithelium.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6rcd" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6rcd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Adhesin 3D structures\|Adhesin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 33530]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aparicio, D]]	+	[[Category: Mycoplasma genitalium]]
-	[[Category: Fita, I]]	+	[[Category: Aparicio D]]
-	[[Category: Illanes, R]]	+	[[Category: Fita I]]
-	[[Category: Perez, R]]	+	[[Category: Illanes R]]
-	[[Category: Vizarraga, D]]	+	[[Category: Perez R]]
-	~~[[Category: Cell adhesion]]~~	+	[[Category: Vizarraga D]]
-	~~[[Category: Domain-refolding]]~~	+
-	~~[[Category: Octamer~~]]	+

OCA at 09:48, 18 November 2020

OCA — Wed, 18 Nov 2020 09:48:38 GMT

←Older revision		Revision as of 09:48, 18 November 2020
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-	==Octamer Domain ~~1 Protein A~~ Mycoplasma genitalium==	+	==Octamer C-Domain P140 Mycoplasma genitalium.==
-	<StructureSection load='6rcd' size='340' side='right'caption='[[6rcd]]' scene=''>	+	<StructureSection load='6rcd' size='340' side='right'caption='[[6rcd]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RCD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RCD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rcd]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33530 Atcc 33530]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RCD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RCD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rcd OCA], [http://pdbe.org/6rcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rcd RCSB], [http://www.ebi.ac.uk/pdbsum/6rcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rcd ProSAT]</span></td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6rcc\|6rcc]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mgpB, MG191 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2097 ATCC 33530])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rcd OCA], [http://pdbe.org/6rcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rcd RCSB], [http://www.ebi.ac.uk/pdbsum/6rcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rcd ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human pathogen Mycoplasma genitalium is responsible for urethritis in men, and for cervicitis and pelvic inflammatory disease in women. The adherence of M. genitalium to host target epithelial cells is mediated through an adhesion complex called Nap, which is essential for infectivity. Nap is a transmembrane dimer of heterodimers of the immunodominant proteins P110 and P140. The M. genitalium genome contains multiple copies of portions that share homology with the extracellular regions of P140 and P110 encoded by the genes mg191 and mg192, respectively. Homologous recombination between the genes and the copies allows the generation of a large diversity of P140 and P110 variants to overcome surveillance by the host immune system. Interestingly, the C-terminal domain (C-domain) of the extracellular region of P140, which is essential for the function of Nap by acting as a flexible stalk anchoring the protein to the mycoplasma membrane, presents a low degree of sequence variability. In the present work, the X-ray crystal structures of two crystal forms of a construct of the P140 C-domain are reported. In both crystal forms, the construct forms a compact octamer with D4 point-group symmetry. The structure of the C-domain determined in this work presents significant differences with respect to the structure of the C-domain found recently in intact P140. The structural plasticity of the C-domain appears to be a possible mechanism that may help in the functioning of the mycoplasma adhesion complex.
		+
		+	Alternative conformation of the C-domain of the P140 protein from Mycoplasma genitalium.,Vizarraga D, Perez-Luque R, Martin J, Fita I, Aparicio D Acta Crystallogr F Struct Biol Commun. 2020 Nov 1;76(Pt 11):508-516. doi:, 10.1107/S2053230X20012297. Epub 2020 Oct 8. PMID:33135669<ref>PMID:33135669</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6rcd" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 33530]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aparicio D]]	+	[[Category: Aparicio, D]]
-	[[Category: Fita I]]	+	[[Category: Fita, I]]
-	[[Category: Illanes R]]	+	[[Category: Illanes, R]]
-	[[Category: Perez R]]	+	[[Category: Perez, R]]
-	[[Category: Vizarraga D]]	+	[[Category: Vizarraga, D]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Domain-refolding]]
		+	[[Category: Octamer]]

OCA at 07:21, 4 November 2020

OCA — Wed, 04 Nov 2020 07:21:17 GMT

←Older revision		Revision as of 07:21, 4 November 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6rcd is ~~ON HOLD until Paper Publication~~	+	==Octamer Domain 1 Protein A Mycoplasma genitalium==
-		+	<StructureSection load='6rcd' size='340' side='right'caption='[[6rcd]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RCD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RCD FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rcd OCA], [http://pdbe.org/6rcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rcd RCSB], [http://www.ebi.ac.uk/pdbsum/6rcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rcd ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Aparicio D]]
		+	[[Category: Fita I]]
		+	[[Category: Illanes R]]
		+	[[Category: Perez R]]
		+	[[Category: Vizarraga D]]

OCA at 07:20, 2 October 2019

OCA — Wed, 02 Oct 2019 07:20:22 GMT

←Older revision		Revision as of 07:20, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6rcd is ON HOLD	+	The entry 6rcd is ON HOLD until Paper Publication

-	Authors: ~~Vizarraga, D., Aparicio, D., Perez, R., Illanes, R., Fita, I.~~	+	Authors:

-	Description: ~~Octamer Domain 1 Protein A Mycoplasma genitalium~~	+	Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Illanes, R]]
-	[[Category: Aparicio, D]]
-	[[Category: Perez, R]]
-	[[Category: Vizarraga, D]]
-	[[Category: Fita, I]]

OCA: Protected "6rcd" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2019 04:27:29 GMT

Protected "6rcd" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:27, 17 April 2019

OCA: New page: '''Unreleased structure''' The entry 6rcd is ON HOLD Authors: Vizarraga, D., Aparicio, D., Perez, R., Illanes, R., Fita, I. Description: Octamer Domain 1 Protein A Mycoplasma genitaliu...

OCA — Wed, 17 Apr 2019 04:27:28 GMT

New page: '''Unreleased structure''' The entry 6rcd is ON HOLD Authors: Vizarraga, D., Aparicio, D., Perez, R., Illanes, R., Fita, I. Description: Octamer Domain 1 Protein A Mycoplasma genitaliu...

New page

'''Unreleased structure'''

The entry 6rcd is ON HOLD

Authors: Vizarraga, D., Aparicio, D., Perez, R., Illanes, R., Fita, I.

Description: Octamer Domain 1 Protein A Mycoplasma genitalium
[[Category: Unreleased Structures]]
[[Category: Illanes, R]]
[[Category: Aparicio, D]]
[[Category: Perez, R]]
[[Category: Vizarraga, D]]
[[Category: Fita, I]]