6rco - Revision history

OCA at 06:41, 10 July 2019

OCA — Wed, 10 Jul 2019 06:41:58 GMT

←Older revision		Revision as of 06:41, 10 July 2019
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	<StructureSection load='6rco' size='340' side='right'caption='[[6rco]], [[Resolution\|resolution]] 1.66Å' scene=''>		<StructureSection load='6rco' size='340' side='right'caption='[[6rco]], [[Resolution\|resolution]] 1.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rco]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RCO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rco]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RCO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rco OCA], [http://pdbe.org/6rco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rco RCSB], [http://www.ebi.ac.uk/pdbsum/6rco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rco ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rco OCA], [http://pdbe.org/6rco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rco RCSB], [http://www.ebi.ac.uk/pdbsum/6rco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rco ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Alanine, D G.W]]		[[Category: Alanine, D G.W]]

OCA at 07:08, 26 June 2019

OCA — Wed, 26 Jun 2019 07:08:34 GMT

←Older revision		Revision as of 07:08, 26 June 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6rco is ~~ON HOLD until Paper~~ Publication	+	==PfRH5-binding monoclonal antibody R5.004==
		+	<StructureSection load='6rco' size='340' side='right'caption='[[6rco]], [[Resolution\|resolution]] 1.66Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6rco]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RCO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rco OCA], [http://pdbe.org/6rco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rco RCSB], [http://www.ebi.ac.uk/pdbsum/6rco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rco ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines against the disease-causing blood-stage of malaria. However, little is known about how human antibodies confer functional immunity against this antigen. We isolated a panel of human monoclonal antibodies (mAbs) against PfRH5 from peripheral blood B cells from vaccinees in the first clinical trial of a PfRH5-based vaccine. We identified a subset of mAbs with neutralizing activity that bind to three distinct sites and another subset of mAbs that are non-functional, or even antagonistic to neutralizing antibodies. We also identify the epitope of a novel group of non-neutralizing antibodies that significantly reduce the speed of red blood cell invasion by the merozoite, thereby potentiating the effect of all neutralizing PfRH5 antibodies as well as synergizing with antibodies targeting other malaria invasion proteins. Our results provide a roadmap for structure-guided vaccine development to maximize antibody efficacy against blood-stage malaria.

-	~~Authors:~~ Alanine, D~~.G.W.~~, ~~Draper~~, S.J., Higgins, M.K.	+	Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.,Alanine DGW, Quinkert D, Kumarasingha R, Mehmood S, Donnellan FR, Minkah NK, Dadonaite B, Diouf A, Galaway F, Silk SE, Jamwal A, Marshall JM, Miura K, Foquet L, Elias SC, Labbe GM, Douglas AD, Jin J, Payne RO, Illingworth JJ, Pattinson DJ, Pulido D, Williams BG, de Jongh WA, Wright GJ, Kappe SHI, Robinson CV, Long CA, Crabb BS, Gilson PR, Higgins MK, Draper SJ Cell. 2019 Jun 13. pii: S0092-8674(19)30553-7. doi: 10.1016/j.cell.2019.05.025. PMID:31204103<ref>PMID:31204103</ref>

-	~~Description: PfRH5-binding monoclonal antibody R5~~.~~004~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Higgins~~, M.K]]	+	<div class="pdbe-citations 6rco" style="background-color:#fffaf0;"></div>
-	[[Category: Draper, S.J]]	+	== References ==
-	[[Category: ~~Alanine~~, ~~D.G.W~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Alanine, D G.W]]
		+	[[Category: Draper, S J]]
		+	[[Category: Higgins, M K]]
		+	[[Category: Immune system]]
		+	[[Category: Plasmodium falciparum erythrocyte invasion neutralisation human monoclonal antibody]]

OCA: Protected "6rco" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2019 04:28:38 GMT

Protected "6rco" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:28, 17 April 2019

OCA: New page: '''Unreleased structure''' The entry 6rco is ON HOLD until Paper Publication Authors: Alanine, D.G.W., Draper, S.J., Higgins, M.K. Description: PfRH5-binding monoclonal antibody R5.004...

OCA — Wed, 17 Apr 2019 04:28:36 GMT

New page: '''Unreleased structure''' The entry 6rco is ON HOLD until Paper Publication Authors: Alanine, D.G.W., Draper, S.J., Higgins, M.K. Description: PfRH5-binding monoclonal antibody R5.004...

New page

'''Unreleased structure'''

The entry 6rco is ON HOLD until Paper Publication

Authors: Alanine, D.G.W., Draper, S.J., Higgins, M.K.

Description: PfRH5-binding monoclonal antibody R5.004
[[Category: Unreleased Structures]]
[[Category: Higgins, M.K]]
[[Category: Draper, S.J]]
[[Category: Alanine, D.G.W]]