6rcu - Revision history

OCA at 06:42, 10 July 2019

OCA — Wed, 10 Jul 2019 06:42:32 GMT

←Older revision		Revision as of 06:42, 10 July 2019
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	<StructureSection load='6rcu' size='340' side='right'caption='[[6rcu]], [[Resolution\|resolution]] 4.00Å' scene=''>		<StructureSection load='6rcu' size='340' side='right'caption='[[6rcu]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rcu]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RCU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RCU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rcu]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RCU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RCU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6rco\|6rco]], [[6rcq\|6rcq]], [[6rcs\|6rcs]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6rco\|6rco]], [[6rcq\|6rcq]], [[6rcs\|6rcs]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PF3D7_0424100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rcu OCA], [http://pdbe.org/6rcu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rcu RCSB], [http://www.ebi.ac.uk/pdbsum/6rcu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rcu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rcu OCA], [http://pdbe.org/6rcu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rcu RCSB], [http://www.ebi.ac.uk/pdbsum/6rcu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rcu ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Plaf7]]
	[[Category: Alanine, D W.G]]		[[Category: Alanine, D W.G]]
	[[Category: Draper, S J]]		[[Category: Draper, S J]]

OCA at 07:09, 26 June 2019

OCA — Wed, 26 Jun 2019 07:09:27 GMT

←Older revision		Revision as of 07:09, 26 June 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6rcu is ~~ON HOLD until Paper~~ Publication	+	==PfRH5 bound to monoclonal antibodies R5.004 and R5.016==
		+	<StructureSection load='6rcu' size='340' side='right'caption='[[6rcu]], [[Resolution\|resolution]] 4.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6rcu]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RCU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RCU FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6rco\|6rco]], [[6rcq\|6rcq]], [[6rcs\|6rcs]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rcu OCA], [http://pdbe.org/6rcu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rcu RCSB], [http://www.ebi.ac.uk/pdbsum/6rcu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rcu ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines against the disease-causing blood-stage of malaria. However, little is known about how human antibodies confer functional immunity against this antigen. We isolated a panel of human monoclonal antibodies (mAbs) against PfRH5 from peripheral blood B cells from vaccinees in the first clinical trial of a PfRH5-based vaccine. We identified a subset of mAbs with neutralizing activity that bind to three distinct sites and another subset of mAbs that are non-functional, or even antagonistic to neutralizing antibodies. We also identify the epitope of a novel group of non-neutralizing antibodies that significantly reduce the speed of red blood cell invasion by the merozoite, thereby potentiating the effect of all neutralizing PfRH5 antibodies as well as synergizing with antibodies targeting other malaria invasion proteins. Our results provide a roadmap for structure-guided vaccine development to maximize antibody efficacy against blood-stage malaria.

-	~~Authors:~~ Alanine, D~~.W.G.~~, ~~Draper~~, S.J., Higgins, M.K.	+	Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.,Alanine DGW, Quinkert D, Kumarasingha R, Mehmood S, Donnellan FR, Minkah NK, Dadonaite B, Diouf A, Galaway F, Silk SE, Jamwal A, Marshall JM, Miura K, Foquet L, Elias SC, Labbe GM, Douglas AD, Jin J, Payne RO, Illingworth JJ, Pattinson DJ, Pulido D, Williams BG, de Jongh WA, Wright GJ, Kappe SHI, Robinson CV, Long CA, Crabb BS, Gilson PR, Higgins MK, Draper SJ Cell. 2019 Jun 13. pii: S0092-8674(19)30553-7. doi: 10.1016/j.cell.2019.05.025. PMID:31204103<ref>PMID:31204103</ref>

-	~~Description: PfRH5 bound to monoclonal antibodies R5~~.~~004 and R5~~.~~016~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Higgins~~, M.K]]	+	<div class="pdbe-citations 6rcu" style="background-color:#fffaf0;"></div>
-	[[Category: Draper, S.J]]	+	== References ==
-	[[Category: ~~Alanine~~, ~~D.W.G~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Alanine, D W.G]]
		+	[[Category: Draper, S J]]
		+	[[Category: Higgins, M K]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Plasmodium falciparum erythrocyte invasion potentiating antibody neutralising antibody human monoclonal antibody]]

OCA at 05:09, 24 April 2019

OCA — Wed, 24 Apr 2019 05:09:00 GMT

←Older revision		Revision as of 05:09, 24 April 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6rcu is ON HOLD	+	The entry 6rcu is ON HOLD until Paper Publication

	Authors: Alanine, D.W.G., Draper, S.J., Higgins, M.K.		Authors: Alanine, D.W.G., Draper, S.J., Higgins, M.K.

OCA: Protected "6rcu" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2019 04:29:18 GMT

Protected "6rcu" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:29, 17 April 2019

OCA: New page: '''Unreleased structure''' The entry 6rcu is ON HOLD Authors: Alanine, D.W.G., Draper, S.J., Higgins, M.K. Description: PfRH5 bound to monoclonal antibodies R5.004 and R5.016 [[Categor...

OCA — Wed, 17 Apr 2019 04:29:16 GMT

New page: '''Unreleased structure''' The entry 6rcu is ON HOLD Authors: Alanine, D.W.G., Draper, S.J., Higgins, M.K. Description: PfRH5 bound to monoclonal antibodies R5.004 and R5.016 [[Categor...

New page

'''Unreleased structure'''

The entry 6rcu is ON HOLD

Authors: Alanine, D.W.G., Draper, S.J., Higgins, M.K.

Description: PfRH5 bound to monoclonal antibodies R5.004 and R5.016
[[Category: Unreleased Structures]]
[[Category: Higgins, M.K]]
[[Category: Draper, S.J]]
[[Category: Alanine, D.W.G]]