6rgy - Revision history

OCA at 12:20, 24 January 2024

OCA — Wed, 24 Jan 2024 12:20:15 GMT

←Older revision		Revision as of 12:20, 24 January 2024
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	<StructureSection load='6rgy' size='340' side='right'caption='[[6rgy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6rgy' size='340' side='right'caption='[[6rgy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rgy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RGY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rgy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RGY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=~~CIT~~:~~CITRIC~~+~~ACID~~'>~~CIT~~</scene>, <scene name='pdbligand=MG:~~MAGNESIUM~~+~~ION~~'>MG</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE~~+ION'>~~SO4~~</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~BFD~~:~~ASPARTATE~~+~~BERYLLIUM+TRIFLUORIDE~~'>~~BFD~~</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BFD:ASPARTATE+BERYLLIUM+TRIFLUORIDE'>BFD</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rgy OCA], [~~http~~://pdbe.org/6rgy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rgy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rgy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rgy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rgy OCA], [https://pdbe.org/6rgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rgy RCSB], [https://www.ebi.ac.uk/pdbsum/6rgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rgy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9WYT9_THEMA Q9WYT9_THEMA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6rgy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6rgy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Response regulator 3D structure\|Response regulator 3D structure]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Casino, P]]	+	[[Category: Thermotoga maritima MSB8]]
-	[[Category: Marina, A]]	+	[[Category: Casino P]]
-	[[Category: Mideros-Mora, C]]	+	[[Category: Marina A]]
-	~~[[Category: Histidine kinase]]~~	+	[[Category: Mideros-Mora C]]
-	~~[[Category: Phosphatase]]~~	+
-	~~[[Category: Phosphotransfer]]~~	+
-	~~[[Category: Response regulator]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 06:31, 19 February 2020

OCA — Wed, 19 Feb 2020 06:31:50 GMT

←Older revision		Revision as of 06:31, 19 February 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6rgy is ~~ON HOLD until Paper~~ Publication	+	==Revisiting pH-gated conformational switch. Complex HK853-RR468 pH 7.5==
		+	<StructureSection load='6rgy' size='340' side='right'caption='[[6rgy]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6rgy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RGY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFD:ASPARTATE+BERYLLIUM+TRIFLUORIDE'>BFD</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rgy OCA], [http://pdbe.org/6rgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rgy RCSB], [http://www.ebi.ac.uk/pdbsum/6rgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rgy ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Histidine is a versatile residue playing key roles in enzyme catalysis thanks to the chemistry of its imidazole group that can serve as nucleophile, general acid or base depending on its protonation state. In bacteria, signal transduction relies on two-component systems (TCS) which comprise a sensor histidine kinase (HK) containing a phosphorylatable catalytic His with phosphotransfer and phosphatase activities over an effector response regulator. Recently, a pH-gated model has been postulated to regulate the phosphatase activity of HisKA HKs based on the pH-dependent rotamer switch of the phosphorylatable His. Here, we have revisited this model from a structural and functional perspective on HK853-RR468 and EnvZ-OmpR TCS, the prototypical HisKA HKs. We have found that the rotamer of His is not influenced by the environmental pH, ruling out a pH-gated model and confirming that the chemistry of the His is responsible for the decrease in the phosphatase activity at acidic pH.

-	~~Authors~~:	+	Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases.,Mideros-Mora C, Miguel-Romero L, Felipe-Ruiz A, Casino P, Marina A Nat Commun. 2020 Feb 7;11(1):769. doi: 10.1038/s41467-020-14540-5. PMID:32034139<ref>PMID:32034139</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6rgy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Casino, P]]
		+	[[Category: Marina, A]]
		+	[[Category: Mideros-Mora, C]]
		+	[[Category: Histidine kinase]]
		+	[[Category: Phosphatase]]
		+	[[Category: Phosphotransfer]]
		+	[[Category: Response regulator]]
		+	[[Category: Signaling protein]]

OCA at 04:13, 22 May 2019

OCA — Wed, 22 May 2019 04:13:14 GMT

←Older revision		Revision as of 04:13, 22 May 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6rgy is ON HOLD	+	The entry 6rgy is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6rgy" [edit=sysop:move=sysop]

OCA — Wed, 24 Apr 2019 05:19:03 GMT

Protected "6rgy" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:19, 24 April 2019

OCA: New page: '''Unreleased structure''' The entry 6rgy is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 24 Apr 2019 05:19:01 GMT

New page: '''Unreleased structure''' The entry 6rgy is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6rgy is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]