OCA at 15:42, 28 August 2019

OCA — Wed, 28 Aug 2019 15:42:28 GMT

←Older revision		Revision as of 15:42, 28 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6rnl is ~~ON HOLD~~	+	==L-[Ru(TAP)2(dppz)]2+ bound to the G-quadruplex forming sequence d(TAGGGTT)==
		+	<StructureSection load='6rnl' size='340' side='right'caption='[[6rnl]], [[Resolution\|resolution]] 1.88Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6rnl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RNL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RKL:RU(TAP)2(DPPZ)+COMPLEX'>RKL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rnl OCA], [http://pdbe.org/6rnl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rnl RCSB], [http://www.ebi.ac.uk/pdbsum/6rnl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rnl ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The new complexes [Ru(TAP)2 (11-CN-dppz)](2+) , [Ru(TAP)2 (11-Br-dppz)](2+) and [Ru(TAP)2 (11,12-diCN-dppz)](2+) are reported. The addition of nitrile substituents to the dppz ligand of the DNA photo-oxidising complex [Ru(TAP)2 (dppz)](2+) promote pi-stacking interactions and ordered binding to DNA, as shown by X-ray crystallography. The structure of Lambda-[Ru(TAP)2 (11-CN-dppz)](2+) with the DNA duplex d(TCGGCGCCGA)2 shows, for the first time with this class of complex, a closed intercalation cavity with an AT base pair at the terminus. The structure obtained is compared to that formed with the 11-Br and 11,12-dinitrile derivatives, highlighting the stabilization of syn guanine by this enantiomer when the terminal base pair is GC. In contrast the AT base pair has the normal Watson-Crick orientation, highlighting the difference in charge distribution between the two purine bases and the complementarity of the dppz-purine interaction. The asymmetry of the cavity highlights the importance of the purine-dppz-purine stacking interaction.

-	~~Authors: McQuaid~~, K~~.T.~~, Hall, ~~J.P.~~, Cardin, C.J.	+	X-ray Crystal Structures Show DNA Stacking Advantage of Terminal Nitrile Substitution in Ru-dppz Complexes.,McQuaid K, Hall JP, Brazier JA, Cardin DJ, Cardin CJ Chemistry. 2018 Oct 22;24(59):15859-15867. doi: 10.1002/chem.201803021. Epub 2018, Oct 1. PMID:30063271<ref>PMID:30063271</ref>

-	~~Description: L-[Ru(TAP)2(dppz)]2+ bound to~~ the G-~~quadruplex forming sequence d(TAGGGTT)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Hall~~, J.P]]	+	<div class="pdbe-citations 6rnl" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Cardin~~, C.J]]	+	== References ==
-	[[Category: ~~Mcquaid~~, K.T]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cardin, C J]]
		+	[[Category: Hall, J P]]
		+	[[Category: McQuaid, K T]]
		+	[[Category: Asymmetric]]
		+	[[Category: Dna]]
		+	[[Category: Intercalation]]
		+	[[Category: Ruthenium]]

OCA: Protected "6rnl" [edit=sysop:move=sysop]

OCA — Tue, 21 May 2019 06:02:27 GMT

Protected "6rnl" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:02, 21 May 2019

OCA: New page: '''Unreleased structure''' The entry 6rnl is ON HOLD Authors: McQuaid, K.T., Hall, J.P., Cardin, C.J. Description: L-[Ru(TAP)2(dppz)]2+ bound to the G-quadruplex forming sequence d(TAG...

OCA — Tue, 21 May 2019 06:02:26 GMT

New page: '''Unreleased structure''' The entry 6rnl is ON HOLD Authors: McQuaid, K.T., Hall, J.P., Cardin, C.J. Description: L-[Ru(TAP)2(dppz)]2+ bound to the G-quadruplex forming sequence d(TAG...

New page

'''Unreleased structure'''

The entry 6rnl is ON HOLD

Authors: McQuaid, K.T., Hall, J.P., Cardin, C.J.

Description: L-[Ru(TAP)2(dppz)]2+ bound to the G-quadruplex forming sequence d(TAGGGTT)
[[Category: Unreleased Structures]]
[[Category: Hall, J.P]]
[[Category: Cardin, C.J]]
[[Category: Mcquaid, K.T]]

6rnl - Revision history

OCA at 15:42, 28 August 2019

OCA: Protected "6rnl" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6rnl is ON HOLD Authors: McQuaid, K.T., Hall, J.P., Cardin, C.J. Description: L-[Ru(TAP)2(dppz)]2+ bound to the G-quadruplex forming sequence d(TAG...