6rod - Revision history

OCA at 12:25, 24 January 2024

OCA — Wed, 24 Jan 2024 12:25:07 GMT

←Older revision		Revision as of 12:25, 24 January 2024
Line 1:		Line 1:

	==Alpha-1-antitrypsin (Ser36Arg/Glu78Arg/Glu266Arg) in the native conformation==		==Alpha-1-antitrypsin (Ser36Arg/Glu78Arg/Glu266Arg) in the native conformation==
-	<StructureSection load='6rod' size='340' side='right'caption='[[6rod]]' scene=''>	+	<StructureSection load='6rod' size='340' side='right'caption='[[6rod]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ROD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ROD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rod]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ROD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ROD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rod OCA], [https://pdbe.org/6rod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rod RCSB], [https://www.ebi.ac.uk/pdbsum/6rod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rod ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rod OCA], [https://pdbe.org/6rod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rod RCSB], [https://www.ebi.ac.uk/pdbsum/6rod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rod ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN] Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD) [MIM:[https://omim.org/entry/613490 613490]. A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.<ref>PMID:1905728</ref> <ref>PMID:2390072</ref> <ref>PMID:2227940</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN] Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.[:]<ref>PMID:1906855</ref> <ref>PMID:1406456</ref> Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).[:]<ref>PMID:1906855</ref> <ref>PMID:1406456</ref>

	==See Also==		==See Also==
	*[[Alpha-1-antitrypsin 3D structures\|Alpha-1-antitrypsin 3D structures]]		*[[Alpha-1-antitrypsin 3D structures\|Alpha-1-antitrypsin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Wan, M, Ronzoni, R, Lomas, DA,~~ Irving, JA]]	+	[[Category: Irving JA]]
		+	[[Category: Lomas DA]]
		+	[[Category: Ronzoni R]]
		+	[[Category: Wan M]]

OCA at 15:17, 8 June 2021

OCA — Tue, 08 Jun 2021 15:17:58 GMT

←Older revision		Revision as of 15:17, 8 June 2021
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	<StructureSection load='6rod' size='340' side='right'caption='[[6rod]]' scene=''>		<StructureSection load='6rod' size='340' side='right'caption='[[6rod]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ROD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6ROD FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ROD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ROD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6rod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rod OCA], [~~http~~://pdbe.org/6rod PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rod RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rod PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rod ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rod OCA], [https://pdbe.org/6rod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rod RCSB], [https://www.ebi.ac.uk/pdbsum/6rod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rod ProSAT]</span></td></tr>
	</table>		</table>
		+
		+	==See Also==
		+	*[[Alpha-1-antitrypsin 3D structures\|Alpha-1-antitrypsin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Wan, M, Ronzoni, R, Lomas, DA, Irving, JA]]		[[Category: Wan, M, Ronzoni, R, Lomas, DA, Irving, JA]]

OCA at 06:27, 3 June 2020

OCA — Wed, 03 Jun 2020 06:27:39 GMT

←Older revision		Revision as of 06:27, 3 June 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6rod is ON HOLD~~	+	==Alpha-1-antitrypsin (Ser36Arg/Glu78Arg/Glu266Arg) in the native conformation==
-		+	<StructureSection load='6rod' size='340' side='right'caption='[[6rod]]' scene=''>
-	~~Authors: Wan, M., Ronzoni, R., Lomas, D.A., Irving, J.A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ROD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ROD FirstGlance]. <br>
-	~~Description:~~ Alpha-1-antitrypsin (Ser36Arg/Glu78Arg/Glu266Arg) in the native conformation	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rod OCA], [http://pdbe.org/6rod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rod RCSB], [http://www.ebi.ac.uk/pdbsum/6rod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rod ProSAT]</span></td></tr>
-	[[~~Category: Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Wan, M]~~]	+	__TOC__
-	[[~~Category~~: ~~Irving~~, J.A]]	+	</StructureSection>
-	[[Category: ~~Ronzoni, R~~]]	+	[[Category: Large Structures]]
-	[[Category: Lomas, ~~D.A~~]]	+	[[Category: Wan, M, Ronzoni, R, Lomas, DA, Irving, JA]]

OCA: Protected "6rod" [edit=sysop:move=sysop]

OCA — Wed, 22 May 2019 04:15:56 GMT

Protected "6rod" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:15, 22 May 2019

OCA: New page: '''Unreleased structure''' The entry 6rod is ON HOLD Authors: Wan, M., Ronzoni, R., Lomas, D.A., Irving, J.A. Description: Alpha-1-antitrypsin (Ser36Arg/Glu78Arg/Glu266Arg) in the nati...

OCA — Wed, 22 May 2019 04:15:55 GMT

New page: '''Unreleased structure''' The entry 6rod is ON HOLD Authors: Wan, M., Ronzoni, R., Lomas, D.A., Irving, J.A. Description: Alpha-1-antitrypsin (Ser36Arg/Glu78Arg/Glu266Arg) in the nati...

New page

'''Unreleased structure'''

The entry 6rod is ON HOLD

Authors: Wan, M., Ronzoni, R., Lomas, D.A., Irving, J.A.

Description: Alpha-1-antitrypsin (Ser36Arg/Glu78Arg/Glu266Arg) in the native conformation
[[Category: Unreleased Structures]]
[[Category: Wan, M]]
[[Category: Irving, J.A]]
[[Category: Ronzoni, R]]
[[Category: Lomas, D.A]]