OCA at 08:08, 11 November 2020

OCA — Wed, 11 Nov 2020 08:08:48 GMT

←Older revision		Revision as of 08:08, 11 November 2020
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	==A Non-blocking anti-CTLA-4 Nanobody complexed with CTLA-4==		==A Non-blocking anti-CTLA-4 Nanobody complexed with CTLA-4==
-	<StructureSection load='6rpj' size='340' side='right'caption='[[6rpj]]' scene=''>	+	<StructureSection load='6rpj' size='340' side='right'caption='[[6rpj]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RPJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RPJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rpj]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bactrian_camel Bactrian camel] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RPJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RPJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rpj OCA], [http://pdbe.org/6rpj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rpj RCSB], [http://www.ebi.ac.uk/pdbsum/6rpj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rpj ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTLA4, CD152 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rpj OCA], [http://pdbe.org/6rpj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rpj RCSB], [http://www.ebi.ac.uk/pdbsum/6rpj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rpj ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CTLA4_HUMAN CTLA4_HUMAN]] Genetic variation in CTLA4 influences susceptibility to systemic lupus erythematosus (SLE) [MIM:[http://omim.org/entry/152700 152700]]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:10924276</ref> Note=Genetic variations in CTLA4 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.<ref>PMID:10924276</ref> Genetic variation in CTLA4 is the cause of susceptibility to diabetes mellitus insulin-dependent type 12 (IDDM12) [MIM:[http://omim.org/entry/601388 601388]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:10924276</ref> <ref>PMID:9259273</ref> Genetic variation in CTLA4 is the cause of susceptibility to celiac disease type 3 (CELIAC3) [MIM:[http://omim.org/entry/609755 609755]]. It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CTLA4_HUMAN CTLA4_HUMAN]] Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.<ref>PMID:1714933</ref> <ref>PMID:16551244</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bactrian camel]]
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gao H]]	+	[[Category: Gao, H]]
-	[[Category: Zhang F]]	+	[[Category: Zhang, F]]
-	[[Category: Zhou A]]	+	[[Category: Zhou, A]]
		+	[[Category: Antibody]]
		+	[[Category: Check-point]]
		+	[[Category: Ctla-4]]
		+	[[Category: Immune system]]
		+	[[Category: Receptor]]

OCA at 14:01, 8 July 2020

OCA — Wed, 08 Jul 2020 14:01:52 GMT

←Older revision		Revision as of 14:01, 8 July 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6rpj is ~~ON HOLD~~	+	==A Non-blocking anti-CTLA-4 Nanobody complexed with CTLA-4==
-		+	<StructureSection load='6rpj' size='340' side='right'caption='[[6rpj]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RPJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RPJ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rpj OCA], [http://pdbe.org/6rpj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rpj RCSB], [http://www.ebi.ac.uk/pdbsum/6rpj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rpj ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Gao H]]
		+	[[Category: Zhang F]]
		+	[[Category: Zhou A]]

OCA: Protected "6rpj" [edit=sysop:move=sysop]

OCA — Wed, 22 May 2019 04:19:38 GMT

Protected "6rpj" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:19, 22 May 2019

OCA: New page: '''Unreleased structure''' The entry 6rpj is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 May 2019 04:19:36 GMT

New page: '''Unreleased structure''' The entry 6rpj is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6rpj is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6rpj - Revision history

OCA at 08:08, 11 November 2020

OCA at 14:01, 8 July 2020

OCA: Protected "6rpj" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6rpj is ON HOLD Authors: Description: Category: Unreleased Structures