OCA at 11:51, 1 February 2024

OCA — Thu, 01 Feb 2024 11:51:40 GMT

←Older revision		Revision as of 11:51, 1 February 2024
Line 3:		Line 3:
	<StructureSection load='6rpz' size='340' side='right'caption='[[6rpz]], [[Resolution\|resolution]] 1.74Å' scene=''>		<StructureSection load='6rpz' size='340' side='right'caption='[[6rpz]], [[Resolution\|resolution]] 1.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rpz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RPZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RPZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rpz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RPZ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">[[~~6rpx~~\|~~6rpx~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.74Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rpz OCA], [~~http~~://pdbe.org/6rpz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rpz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rpz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rpz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rpz OCA], [https://pdbe.org/6rpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rpz RCSB], [https://www.ebi.ac.uk/pdbsum/6rpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rpz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CRLF3_MOUSE CRLF3_MOUSE]] May play a role in the negative regulation of cell cycle progression.	+	[https://www.uniprot.org/uniprot/CRLF3_MOUSE CRLF3_MOUSE] May play a role in the negative regulation of cell cycle progression.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The process of platelet production has so far been understood to be a 2-stage process: megakaryocyte maturation from hematopoietic stem cells followed by proplatelet formation, with each phase regulating the peripheral blood platelet count. Proplatelet formation releases into the bloodstream beads-on-a-string preplatelets, which undergo fission into mature platelets. For the first time, we show that preplatelet maturation is a third, tightly regulated, critical process akin to cytokinesis that regulates platelet count. We show that deficiency in cytokine receptor-like factor 3 (CRLF3) in mice leads to an isolated and sustained 25% to 48% reduction in the platelet count without any effect on other blood cell lineages. We show that Crlf3-/- preplatelets have increased microtubule stability, possibly because of increased microtubule glutamylation via the interaction of CRLF3 with key members of the Hippo pathway. Using a mouse model of JAK2 V617F essential thrombocythemia, we show that a lack of CRLF3 leads to long-term lineage-specific normalization of the platelet count. We thereby postulate that targeting CRLF3 has therapeutic potential for treatment of thrombocythemia.
		+
		+	CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia.,Bennett C, Lawrence M, Guerrero JA, Stritt S, Waller AK, Yan Y, Mifsud RW, Ballester-Beltran J, Baig A, Mueller A, Mayer L, Warland J, Penkett CJ, Akbari P, Moreau T, Evans AL, Mookerjee S, Hoffman GJ, Saeb-Parsy K, Adams DJ, Couzens AL, Bender M, Erber WN, Nieswandt B, Read RJ, Ghevaert C Blood. 2022 Apr 7;139(14):2227-2239. doi: 10.1182/blood.2021013113. PMID:35051265<ref>PMID:35051265</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6rpz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Bennett, C~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Mifsud, R W~~]]	+	[[Category: Bennett C]]
-	[[Category: ~~Read, R J~~]]	+	[[Category: Mifsud RW]]
-	[[Category: ~~Yan, Y~~]]	+	[[Category: Read RJ]]
-	[[Category: ~~Blood clotting]]~~	+	[[Category: Yan Y]]
-	~~[[Category: Fibronectin domain]]~~	+
-	~~[[Category: Platelet development]]~~	+
-	~~[[Category: Spry domain~~]]	+

OCA at 10:17, 27 March 2020

OCA — Fri, 27 Mar 2020 10:17:08 GMT

←Older revision		Revision as of 10:17, 27 March 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6rpz is ~~ON HOLD until Paper Publication~~	+	==Cytokine receptor-like factor 3 C-terminus residues 174-442: native collected with 1.7A wavelength==
-		+	<StructureSection load='6rpz' size='340' side='right'caption='[[6rpz]], [[Resolution\|resolution]] 1.74Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6rpz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RPZ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6rpx\|6rpx]]</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rpz OCA], [http://pdbe.org/6rpz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rpz RCSB], [http://www.ebi.ac.uk/pdbsum/6rpz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rpz ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CRLF3_MOUSE CRLF3_MOUSE]] May play a role in the negative regulation of cell cycle progression.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bennett, C]]
		+	[[Category: Mifsud, R W]]
		+	[[Category: Read, R J]]
		+	[[Category: Yan, Y]]
		+	[[Category: Blood clotting]]
		+	[[Category: Fibronectin domain]]
		+	[[Category: Platelet development]]
		+	[[Category: Spry domain]]

OCA: Protected "6rpz" [edit=sysop:move=sysop]

OCA — Wed, 22 May 2019 04:20:45 GMT

Protected "6rpz" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:20, 22 May 2019

OCA: New page: '''Unreleased structure''' The entry 6rpz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 May 2019 04:20:44 GMT

New page: '''Unreleased structure''' The entry 6rpz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6rpz is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

6rpz - Revision history

OCA at 11:51, 1 February 2024

OCA at 10:17, 27 March 2020

OCA: Protected "6rpz" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6rpz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures