6rqs - Revision history

OCA at 11:01, 14 June 2023

OCA — Wed, 14 Jun 2023 11:01:34 GMT

←Older revision		Revision as of 11:01, 14 June 2023
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	==RW16 peptide==		==RW16 peptide==
-	<StructureSection load='6rqs' size='340' side='right'caption='[[6rqs~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='6rqs' size='340' side='right'caption='[[6rqs]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rqs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RQS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rqs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RQS FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=KFB:'>KFB</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=KFB:5-Aminovaleric+Acid'>KFB</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rqs OCA], [~~http~~://pdbe.org/6rqs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rqs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rqs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rqs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rqs OCA], [https://pdbe.org/6rqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rqs RCSB], [https://www.ebi.ac.uk/pdbsum/6rqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rqs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alves, I]]	+	[[Category: Synthetic construct]]
-	[[Category: Grelard, A]]	+	[[Category: Alves I]]
-	[[Category: Jobin, M L]]	+	[[Category: Grelard A]]
-	[[Category: Mackereth~~, C D]]~~	+	[[Category: Jobin M-L]]
-	~~[[Category: Arginine]]~~	+	[[Category: Mackereth CD]]
-	~~[[Category: Cell-penetrating]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Tryptophan~~]]	+

OCA at 07:02, 23 October 2019

OCA — Wed, 23 Oct 2019 07:02:08 GMT

←Older revision		Revision as of 07:02, 23 October 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6rqs is ~~ON HOLD until Paper~~ Publication	+	==RW16 peptide==
		+	<StructureSection load='6rqs' size='340' side='right'caption='[[6rqs]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6rqs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RQS FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=KFB:'>KFB</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rqs OCA], [http://pdbe.org/6rqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rqs RCSB], [http://www.ebi.ac.uk/pdbsum/6rqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rqs ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cell-penetrating peptides (CPPs) are short peptides that can translocate and transport cargoes into the intracellular milieu by crossing biological membranes. The mode of interaction and internalization of cell-penetrating peptides has long been controversial. While their interaction with anionic membranes is quite well understood, the insertion and behavior of CPPs in zwitterionic membranes, a major lipid component of eukaryotic cell membranes, is poorly studied. Herein, we investigated the membrane insertion of RW16 into zwitterionic membranes, a versatile CPP that also presents antibacterial and antitumor activities. Using complementary approaches, including NMR spectroscopy, fluorescence spectroscopy, circular dichroism, and molecular dynamic simulations, we determined the high-resolution structure of RW16 and measured its membrane insertion and orientation properties into zwitterionic membranes. Altogether, these results contribute to explaining the versatile properties of this peptide toward zwitterionic lipids.

-	~~Authors:~~ Jobin, ~~M.-~~L., ~~Grelard~~, A~~., Alves, I.~~, Mackereth, C.D.	+	Biophysical Insight on the Membrane Insertion of an Arginine-Rich Cell-Penetrating Peptide.,Jobin ML, Vamparys L, Deniau R, Grelard A, Mackereth CD, Fuchs PFJ, Alves ID Int J Mol Sci. 2019 Sep 9;20(18). pii: ijms20184441. doi: 10.3390/ijms20184441. PMID:31505894<ref>PMID:31505894</ref>

-	~~Description~~: ~~RW16 peptide~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6rqs" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Alves, I]]		[[Category: Alves, I]]
-	[[Category: Jobin, M.-L]]
-	[[Category: Mackereth, C.D]]
	[[Category: Grelard, A]]		[[Category: Grelard, A]]
		+	[[Category: Jobin, M L]]
		+	[[Category: Mackereth, C D]]
		+	[[Category: Arginine]]
		+	[[Category: Cell-penetrating]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: Tryptophan]]

OCA at 04:42, 29 May 2019

OCA — Wed, 29 May 2019 04:42:25 GMT

←Older revision		Revision as of 04:42, 29 May 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6rqs is ON HOLD	+	The entry 6rqs is ON HOLD until Paper Publication

	Authors: Jobin, M.-L., Grelard, A., Alves, I., Mackereth, C.D.		Authors: Jobin, M.-L., Grelard, A., Alves, I., Mackereth, C.D.

OCA: Protected "6rqs" [edit=sysop:move=sysop]

OCA — Wed, 22 May 2019 04:22:31 GMT

Protected "6rqs" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:22, 22 May 2019

OCA: New page: '''Unreleased structure''' The entry 6rqs is ON HOLD Authors: Jobin, M.-L., Grelard, A., Alves, I., Mackereth, C.D. Description: RW16 peptide Category: Unreleased Structures [[Cate...

OCA — Wed, 22 May 2019 04:22:30 GMT

New page: '''Unreleased structure''' The entry 6rqs is ON HOLD Authors: Jobin, M.-L., Grelard, A., Alves, I., Mackereth, C.D. Description: RW16 peptide Category: Unreleased Structures [[Cate...

New page

'''Unreleased structure'''

The entry 6rqs is ON HOLD

Authors: Jobin, M.-L., Grelard, A., Alves, I., Mackereth, C.D.

Description: RW16 peptide
[[Category: Unreleased Structures]]
[[Category: Alves, I]]
[[Category: Jobin, M.-L]]
[[Category: Mackereth, C.D]]
[[Category: Grelard, A]]