6rvc - Revision history

OCA at 12:29, 24 January 2024

OCA — Wed, 24 Jan 2024 12:29:38 GMT

←Older revision		Revision as of 12:29, 24 January 2024
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	<StructureSection load='6rvc' size='340' side='right'caption='[[6rvc]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6rvc' size='340' side='right'caption='[[6rvc]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rvc]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Camelus_glama Camelus glama~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RVC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RVC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rvc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RVC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PTCH1, PTCH ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rvc OCA], [~~http~~://pdbe.org/6rvc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rvc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rvc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rvc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rvc OCA], [https://pdbe.org/6rvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rvc RCSB], [https://www.ebi.ac.uk/pdbsum/6rvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rvc ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN]] Semilobar holoprosencephaly;Monosomy 9q22.3;Alobar holoprosencephaly;Microform holoprosencephaly;Septopreoptic holoprosencephaly;Gorlin syndrome;Lobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN] Semilobar holoprosencephaly;Monosomy 9q22.3;Alobar holoprosencephaly;Microform holoprosencephaly;Septopreoptic holoprosencephaly;Gorlin syndrome;Lobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN]] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref>	+	[https://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6rvc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6rvc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Protein patched homolog 1\|Protein patched homolog 1]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Camelus glama~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Lama glama]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ansell~~, T B~~]]	+	[[Category: Ansell TB]]
-	[[Category: Bishop, B]]	+	[[Category: Bishop B]]
-	[[Category: Covey~~, D F~~]]	+	[[Category: Covey DF]]
-	[[Category: Duman, R]]	+	[[Category: Duman R]]
-	[[Category: ~~Kinnebrew, M~~]]	+	[[Category: El Omari K]]
-	[[Category: ~~Kowatsch, C~~]]	+	[[Category: Kinnebrew M]]
-	[[Category: ~~Malinauskas, T~~]]	+	[[Category: Kowatsch C]]
-	[[Category: ~~Omari, K El~~]]	+	[[Category: Malinauskas T]]
-	[[Category: Pardon, E]]	+	[[Category: Pardon E]]
-	[[Category: Qian, M]]	+	[[Category: Qian M]]
-	[[Category: Rohatgi, R]]	+	[[Category: Rohatgi R]]
-	[[Category: Rudolf~~, A F~~]]	+	[[Category: Rudolf AF]]
-	[[Category: Sansom~~, M S.P~~]]	+	[[Category: Sansom MSP]]
-	[[Category: Schwab~~, R A~~]]	+	[[Category: Schwab RA]]
-	[[Category: Siebold, C]]	+	[[Category: Siebold C]]
-	[[Category: Steyaert, J]]	+	[[Category: Steyaert J]]
-	[[Category: Wagner, A]]	+	[[Category: Wagner A]]
-	~~[[Category: Hedgehog morphogen receptor]]~~	+
-	~~[[Category: Cholesterol]]~~	+
-	~~[[Category: Lipid-protein-modification]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Palmitate]]~~	+
-	~~[[Category: Receptor-nanobody complex~~]]	+

OCA at 06:26, 10 October 2019

OCA — Thu, 10 Oct 2019 06:26:09 GMT

←Older revision		Revision as of 06:26, 10 October 2019
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	<StructureSection load='6rvc' size='340' side='right'caption='[[6rvc]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6rvc' size='340' side='right'caption='[[6rvc]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rvc]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RVC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rvc]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RVC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTCH1, PTCH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rvc OCA], [http://pdbe.org/6rvc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rvc RCSB], [http://www.ebi.ac.uk/pdbsum/6rvc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rvc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rvc OCA], [http://pdbe.org/6rvc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rvc RCSB], [http://www.ebi.ac.uk/pdbsum/6rvc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rvc ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Camelus glama]]
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ansell, T B]]		[[Category: Ansell, T B]]

OCA at 10:41, 2 October 2019

OCA — Wed, 02 Oct 2019 10:41:30 GMT

←Older revision		Revision as of 10:41, 2 October 2019
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-	'''Unreleased structure'''

-	The entry ~~6rvc~~ is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of Patched-1 ectodomain 2 (PTCH1-ECD2) in complex with nanobody 75==
		+	<StructureSection load='6rvc' size='340' side='right'caption='[[6rvc]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6rvc]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RVC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rvc OCA], [http://pdbe.org/6rvc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rvc RCSB], [http://www.ebi.ac.uk/pdbsum/6rvc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rvc ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN]] Semilobar holoprosencephaly;Monosomy 9q22.3;Alobar holoprosencephaly;Microform holoprosencephaly;Septopreoptic holoprosencephaly;Gorlin syndrome;Lobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN]] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hedgehog (HH) ligands, classical morphogens that pattern embryonic tissues in all animals, are covalently coupled to two lipids-a palmitoyl group at the N terminus and a cholesteroyl group at the C terminus. While the palmitoyl group binds and inactivates Patched 1 (PTCH1), the main receptor for HH ligands, the function of the cholesterol modification has remained mysterious. Using structural and biochemical studies, along with reassessment of previous cryo-electron microscopy structures, we find that the C-terminal cholesterol attached to Sonic hedgehog (Shh) binds the first extracellular domain of PTCH1 and promotes its inactivation, thus triggering HH signaling. Molecular dynamics simulations show that this interaction leads to the closure of a tunnel through PTCH1 that serves as the putative conduit for sterol transport. Thus, Shh inactivates PTCH1 by grasping its extracellular domain with two lipidic pincers, the N-terminal palmitate and the C-terminal cholesterol, which are both inserted into the PTCH1 protein core.

-	~~Authors~~:	+	The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.,Rudolf AF, Kinnebrew M, Kowatsch C, Ansell TB, El Omari K, Bishop B, Pardon E, Schwab RA, Malinauskas T, Qian M, Duman R, Covey DF, Steyaert J, Wagner A, Sansom MSP, Rohatgi R, Siebold C Nat Chem Biol. 2019 Oct;15(10):975-982. doi: 10.1038/s41589-019-0370-y. Epub 2019, Sep 23. PMID:31548691<ref>PMID:31548691</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6rvc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ansell, T B]]
		+	[[Category: Bishop, B]]
		+	[[Category: Covey, D F]]
		+	[[Category: Duman, R]]
		+	[[Category: Kinnebrew, M]]
		+	[[Category: Kowatsch, C]]
		+	[[Category: Malinauskas, T]]
		+	[[Category: Omari, K El]]
		+	[[Category: Pardon, E]]
		+	[[Category: Qian, M]]
		+	[[Category: Rohatgi, R]]
		+	[[Category: Rudolf, A F]]
		+	[[Category: Sansom, M S.P]]
		+	[[Category: Schwab, R A]]
		+	[[Category: Siebold, C]]
		+	[[Category: Steyaert, J]]
		+	[[Category: Wagner, A]]
		+	[[Category: Hedgehog morphogen receptor]]
		+	[[Category: Cholesterol]]
		+	[[Category: Lipid-protein-modification]]
		+	[[Category: Membrane protein]]
		+	[[Category: Palmitate]]
		+	[[Category: Receptor-nanobody complex]]

OCA at 05:24, 26 June 2019

OCA — Wed, 26 Jun 2019 05:24:20 GMT

←Older revision		Revision as of 05:24, 26 June 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6rvc is ON HOLD	+	The entry 6rvc is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6rvc" [edit=sysop:move=sysop]

OCA — Wed, 12 Jun 2019 04:12:10 GMT

Protected "6rvc" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:12, 12 June 2019

OCA: New page: '''Unreleased structure''' The entry 6rvc is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Jun 2019 04:12:09 GMT

New page: '''Unreleased structure''' The entry 6rvc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6rvc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]