6rw6 - Revision history

OCA at 10:13, 22 May 2024

OCA — Wed, 22 May 2024 10:13:21 GMT

←Older revision		Revision as of 10:13, 22 May 2024
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	<SX load='6rw6' size='340' side='right' viewer='molstar' caption='[[6rw6]], [[Resolution\|resolution]] 2.75Å' scene=''>		<SX load='6rw6' size='340' side='right' viewer='molstar' caption='[[6rw6]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rw6]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_29999 Atcc 29999~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RW6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6RW6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rw6]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Photorhabdus_luminescens Photorhabdus luminescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RW6 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~tcdA~~, ~~tcdA1 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=29488 ATCC 29999])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.75Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6rw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rw6 OCA], [~~http~~://pdbe.org/6rw6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rw6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rw6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rw6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rw6 OCA], [https://pdbe.org/6rw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rw6 RCSB], [https://www.ebi.ac.uk/pdbsum/6rw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rw6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9RN43_PHOLU Q9RN43_PHOLU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: Atcc 29999]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Benz, R]]	+	[[Category: Photorhabdus luminescens]]
-	[[Category: Gatsogiannis, C]]	+	[[Category: Benz R]]
-	[[Category: Leidreiter, F]]	+	[[Category: Gatsogiannis C]]
-	[[Category: Meusch, D]]	+	[[Category: Leidreiter F]]
-	[[Category: Raunser, S]]	+	[[Category: Meusch D]]
-	[[Category: Roderer, D]]	+	[[Category: Raunser S]]
-	~~[[Category: Complex]]~~	+	[[Category: Roderer D]]
-	~~[[Category: Membrane permeation]]~~	+
-	~~[[Category: Toxin]]~~	+
-	~~[[Category: Translocation~~]]	+

OCA at 05:52, 11 April 2020

OCA — Sat, 11 Apr 2020 05:52:46 GMT

←Older revision		Revision as of 05:52, 11 April 2020
Line 3:		Line 3:
	<SX load='6rw6' size='340' side='right' viewer='molstar' caption='[[6rw6]], [[Resolution\|resolution]] 2.75Å' scene=''>		<SX load='6rw6' size='340' side='right' viewer='molstar' caption='[[6rw6]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rw6]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29999 Atcc 29999]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RW6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RW6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rw6]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29999 Atcc 29999]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RW6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RW6 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tcdA, tcdA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29488 ATCC 29999])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tcdA, tcdA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29488 ATCC 29999])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rw6 OCA], [http://pdbe.org/6rw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rw6 RCSB], [http://www.ebi.ac.uk/pdbsum/6rw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rw6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rw6 OCA], [http://pdbe.org/6rw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rw6 RCSB], [http://www.ebi.ac.uk/pdbsum/6rw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rw6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:25, 7 March 2020

OCA — Sat, 07 Mar 2020 00:25:26 GMT

←Older revision		Revision as of 00:25, 7 March 2020
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	==Cryo-EM structure of Photorhabdus luminescens TcdA1==		==Cryo-EM structure of Photorhabdus luminescens TcdA1==
-	<~~StructureSection~~ load='6rw6' size='340' side='right'caption='[[6rw6]], [[Resolution\|resolution]] 2.75Å' scene=''>	+	<SX load='6rw6' size='340' side='right' viewer='molstar' caption='[[6rw6]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6rw6]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29999 Atcc 29999]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RW6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rw6]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29999 Atcc 29999]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RW6 FirstGlance]. <br>
Line 19:		Line 19:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Atcc 29999]]		[[Category: Atcc 29999]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 08:48, 6 November 2019

OCA — Wed, 06 Nov 2019 08:48:09 GMT

←Older revision		Revision as of 08:48, 6 November 2019
Line 3:		Line 3:
	<StructureSection load='6rw6' size='340' side='right'caption='[[6rw6]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='6rw6' size='340' side='right'caption='[[6rw6]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rw6]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RW6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rw6]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29999 Atcc 29999]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RW6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rw6 OCA], [http://pdbe.org/6rw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rw6 RCSB], [http://www.ebi.ac.uk/pdbsum/6rw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rw6 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tcdA, tcdA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29488 ATCC 29999])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rw6 OCA], [http://pdbe.org/6rw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rw6 RCSB], [http://www.ebi.ac.uk/pdbsum/6rw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rw6 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tc toxins use a syringe-like mechanism to penetrate the membrane and translocate toxic enzymes into the host cytosol. They are composed of three components: TcA, TcB, and TcC. Low-resolution structures of TcAs from different bacteria suggest a considerable difference in their architecture and possibly in their mechanism of action. Here, we present high-resolution structures of five TcAs from insect and human pathogens, which show a similar overall composition and domain organization. Essential structural features, including a trefoil protein knot, are present in all TcAs, suggesting a common mechanism of action. All TcAs form functional pores and can be combined with TcB-TcC subunits from other species to form active chimeric holotoxins. We identified a conserved ionic pair that stabilizes the shell, likely operating as a strong latch that only springs open after destabilization of other regions. Our results provide new insights into the architecture and mechanism of the Tc toxin family.
		+
		+	Common architecture of Tc toxins from human and insect pathogenic bacteria.,Leidreiter F, Roderer D, Meusch D, Gatsogiannis C, Benz R, Raunser S Sci Adv. 2019 Oct 16;5(10):eaax6497. doi: 10.1126/sciadv.aax6497. eCollection, 2019 Oct. PMID:31663026<ref>PMID:31663026</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6rw6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 29999]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Benz, R]]		[[Category: Benz, R]]

OCA at 07:02, 23 October 2019

OCA — Wed, 23 Oct 2019 07:02:36 GMT

←Older revision		Revision as of 07:02, 23 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6rw6 is ~~ON HOLD~~	+	==Cryo-EM structure of Photorhabdus luminescens TcdA1==
-		+	<StructureSection load='6rw6' size='340' side='right'caption='[[6rw6]], [[Resolution\|resolution]] 2.75Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6rw6]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RW6 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rw6 OCA], [http://pdbe.org/6rw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rw6 RCSB], [http://www.ebi.ac.uk/pdbsum/6rw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rw6 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Benz, R]]
		+	[[Category: Gatsogiannis, C]]
		+	[[Category: Leidreiter, F]]
		+	[[Category: Meusch, D]]
		+	[[Category: Raunser, S]]
		+	[[Category: Roderer, D]]
		+	[[Category: Complex]]
		+	[[Category: Membrane permeation]]
		+	[[Category: Toxin]]
		+	[[Category: Translocation]]

OCA: Protected "6rw6" [edit=sysop:move=sysop]

OCA — Wed, 12 Jun 2019 04:13:48 GMT

Protected "6rw6" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:13, 12 June 2019

OCA: New page: '''Unreleased structure''' The entry 6rw6 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Jun 2019 04:13:47 GMT

New page: '''Unreleased structure''' The entry 6rw6 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6rw6 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]