6rwm - Revision history

OCA at 11:06, 30 March 2022

OCA — Wed, 30 Mar 2022 11:06:59 GMT

←Older revision		Revision as of 11:06, 30 March 2022
Line 3:		Line 3:
	<SX load='6rwm' size='340' side='right' viewer='molstar' caption='[[6rwm]], [[Resolution\|resolution]] 2.81Å' scene=''>		<SX load='6rwm' size='340' side='right' viewer='molstar' caption='[[6rwm]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rwm]] is a 16 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/ ] and [~~http~~://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RWM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6RWM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rwm]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RWM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KLQ:Bictegravir'>KLQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KLQ:Bictegravir'>KLQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11723 CIV])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11723 CIV])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rwm OCA], [~~http~~://pdbe.org/6rwm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rwm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rwm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rwm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rwm OCA], [https://pdbe.org/6rwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rwm RCSB], [https://www.ebi.ac.uk/pdbsum/6rwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rwm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:54, 11 April 2020

OCA — Sat, 11 Apr 2020 05:54:24 GMT

←Older revision		Revision as of 05:54, 11 April 2020
Line 3:		Line 3:
	<SX load='6rwm' size='340' side='right' viewer='molstar' caption='[[6rwm]], [[Resolution\|resolution]] 2.81Å' scene=''>		<SX load='6rwm' size='340' side='right' viewer='molstar' caption='[[6rwm]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rwm]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RWM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RWM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rwm]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RWM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RWM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KLQ:Bictegravir'>KLQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KLQ:Bictegravir'>KLQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11723 CIV])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11723 CIV])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rwm OCA], [http://pdbe.org/6rwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rwm RCSB], [http://www.ebi.ac.uk/pdbsum/6rwm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rwm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rwm OCA], [http://pdbe.org/6rwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rwm RCSB], [http://www.ebi.ac.uk/pdbsum/6rwm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rwm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:26, 7 March 2020

OCA — Sat, 07 Mar 2020 00:26:02 GMT

←Older revision		Revision as of 00:26, 7 March 2020
Line 1:		Line 1:

	==SIVrcm intasome in complex with bictegravir==		==SIVrcm intasome in complex with bictegravir==
-	<~~StructureSection~~ load='6rwm' size='340' side='right'caption='[[6rwm]], [[Resolution\|resolution]] 2.81Å' scene=''>	+	<SX load='6rwm' size='340' side='right' viewer='molstar' caption='[[6rwm]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6rwm]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RWM FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rwm]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RWM FirstGlance]. <br>
Line 20:		Line 20:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Civ]]		[[Category: Civ]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 10:30, 26 February 2020

OCA — Wed, 26 Feb 2020 10:30:03 GMT

←Older revision		Revision as of 10:30, 26 February 2020
Line 25:		Line 25:
	[[Category: Cherepanov, P]]		[[Category: Cherepanov, P]]
	[[Category: Cook, N]]		[[Category: Cook, N]]
		+	[[Category: Nans, A]]
	[[Category: Lentivirus]]		[[Category: Lentivirus]]
	[[Category: Protein-dna complex]]		[[Category: Protein-dna complex]]

OCA at 07:31, 19 February 2020

OCA — Wed, 19 Feb 2020 07:31:28 GMT

←Older revision		Revision as of 07:31, 19 February 2020
Line 3:		Line 3:
	<StructureSection load='6rwm' size='340' side='right'caption='[[6rwm]], [[Resolution\|resolution]] 2.81Å' scene=''>		<StructureSection load='6rwm' size='340' side='right'caption='[[6rwm]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rwm]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RWM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rwm]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RWM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KLQ:Bictegravir'>KLQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KLQ:Bictegravir'>KLQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11723 CIV])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rwm OCA], [http://pdbe.org/6rwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rwm RCSB], [http://www.ebi.ac.uk/pdbsum/6rwm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rwm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rwm OCA], [http://pdbe.org/6rwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rwm RCSB], [http://www.ebi.ac.uk/pdbsum/6rwm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rwm ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Although second-generation HIV integrase strand-transfer inhibitors (INSTIs) are prescribed throughout the world, the mechanistic basis for the superiority of these drugs is poorly understood. We used single-particle cryo-electron microscopy to visualize the mode of action of the advanced INSTIs dolutegravir and bictegravir at near-atomic resolution. Glutamine-148-->histidine (Q148H) and glycine-140-->serine (G140S) amino acid substitutions in integrase that result in clinical INSTI failure perturb optimal magnesium ion coordination in the enzyme active site. The expanded chemical scaffolds of second-generation compounds mediate interactions with the protein backbone that are critical for antagonizing viruses containing the Q148H and G140S mutations. Our results reveal that binding to magnesium ions underpins a fundamental weakness of the INSTI pharmacophore that is exploited by the virus to engender resistance and provide a structural framework for the development of this class of anti-HIV/AIDS therapeutics.
		+
		+	Structural basis of second-generation HIV integrase inhibitor action and viral resistance.,Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P Science. 2020 Feb 14;367(6479):806-810. doi: 10.1126/science.aay4919. Epub 2020, Jan 30. PMID:32001525<ref>PMID:32001525</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6rwm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Civ]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cherepanov, P]]		[[Category: Cherepanov, P]]

OCA at 08:08, 5 February 2020

OCA — Wed, 05 Feb 2020 08:08:17 GMT

←Older revision		Revision as of 08:08, 5 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6rwm ~~is ON HOLD until Paper Publication~~	+	==SIVrcm intasome in complex with bictegravir==
-		+	<StructureSection load='6rwm' size='340' side='right'caption='[[6rwm]], [[Resolution\|resolution]] 2.81Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6rwm]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RWM FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KLQ:Bictegravir'>KLQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rwm OCA], [http://pdbe.org/6rwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rwm RCSB], [http://www.ebi.ac.uk/pdbsum/6rwm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rwm ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cherepanov, P]]
		+	[[Category: Cook, N]]
		+	[[Category: Lentivirus]]
		+	[[Category: Protein-dna complex]]
		+	[[Category: Recombination]]
		+	[[Category: Retroviral integrase]]
		+	[[Category: Strand transfer inhibior]]

OCA: Protected "6rwm" [edit=sysop:move=sysop]

OCA — Wed, 12 Jun 2019 04:14:49 GMT

Protected "6rwm" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:14, 12 June 2019

OCA: New page: '''Unreleased structure''' The entry 6rwm is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Jun 2019 04:14:48 GMT

New page: '''Unreleased structure''' The entry 6rwm is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6rwm is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]