6rxx - Revision history

OCA at 10:13, 22 May 2024

OCA — Wed, 22 May 2024 10:13:40 GMT

←Older revision		Revision as of 10:13, 22 May 2024
Line 3:		Line 3:
	<SX load='6rxx' size='340' side='right' viewer='molstar' caption='[[6rxx]], [[Resolution\|resolution]] 7.10Å' scene=''>		<SX load='6rxx' size='340' side='right' viewer='molstar' caption='[[6rxx]], [[Resolution\|resolution]] 7.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rxx]] is a 68 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6RXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rxx]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RXX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 7.1Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6rxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rxx OCA], [~~http~~://pdbe.org/6rxx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rxx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rxx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rxx ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rxx OCA], [https://pdbe.org/6rxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rxx RCSB], [https://www.ebi.ac.uk/pdbsum/6rxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rxx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/G0S3V7_CHATD G0S3V7_CHATD]] Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.[PIRNR:PIRNR006515] [[http://www.uniprot.org/uniprot/PNO1_CHATD PNO1_CHATD]] Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.[UniProtKB:Q99216] [[http://www.uniprot.org/uniprot/NOL10_CHATD NOL10_CHATD]] May be involved in rRNA-processing and ribosome biosynthesis.[UniProtKB:P48234] [[http://www.uniprot.org/uniprot/UTP11_CHATD UTP11_CHATD]] Involved in nucleolar processing of pre-18S ribosomal RNA.[UniProtKB:P34247]	+	[https://www.uniprot.org/uniprot/G0SF93_CHATD G0SF93_CHATD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	==See Also==		==See Also==
	*[[Ribosome 3D structures\|Ribosome 3D structures]]		*[[Ribosome 3D structures\|Ribosome 3D structures]]
		+	*[[Ribosome biogenesis protein 3D structures\|Ribosome biogenesis protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 29:
	[[Category: Chaetomium thermophilum]]		[[Category: Chaetomium thermophilum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Beckmann, R]]	+	[[Category: Beckmann R]]
-	[[Category: Berninghausen, O]]	+	[[Category: Berninghausen O]]
-	[[Category: Cheng, J]]	+	[[Category: Cheng J]]
-	[[Category: Griesel, S]]	+	[[Category: Griesel S]]
-	[[Category: Hurt, E]]	+	[[Category: Hurt E]]
-	[[Category: Kellner, N]]	+	[[Category: Kellner N]]
-	~~[[Category: Ribosome]]~~	+
-	~~[[Category: Ribosome biogenesis]]~~	+
-	~~[[Category: Rrna~~]]	+

OCA at 05:56, 11 April 2020

OCA — Sat, 11 Apr 2020 05:56:03 GMT

←Older revision		Revision as of 05:56, 11 April 2020
Line 3:		Line 3:
	<SX load='6rxx' size='340' side='right' viewer='molstar' caption='[[6rxx]], [[Resolution\|resolution]] 7.10Å' scene=''>		<SX load='6rxx' size='340' side='right' viewer='molstar' caption='[[6rxx]], [[Resolution\|resolution]] 7.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rxx]] is a 68 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rxx]] is a 68 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RXX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rxx OCA], [http://pdbe.org/6rxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rxx RCSB], [http://www.ebi.ac.uk/pdbsum/6rxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rxx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rxx OCA], [http://pdbe.org/6rxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rxx RCSB], [http://www.ebi.ac.uk/pdbsum/6rxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rxx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 00:37, 7 March 2020

OCA — Sat, 07 Mar 2020 00:37:00 GMT

←Older revision		Revision as of 00:37, 7 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state C, Poly-Ala==		==Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state C, Poly-Ala==
-	<~~StructureSection~~ load='6rxx' size='340' side='right'caption='[[6rxx]], [[Resolution\|resolution]] 7.10Å' scene=''>	+	<SX load='6rxx' size='340' side='right' viewer='molstar' caption='[[6rxx]], [[Resolution\|resolution]] 7.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6rxx]] is a 68 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RXX FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rxx]] is a 68 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RXX FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 6rxx" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6rxx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribosome 3D structures\|Ribosome 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Chaetomium thermophilum]]		[[Category: Chaetomium thermophilum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 16:47, 14 August 2019

OCA — Wed, 14 Aug 2019 16:47:14 GMT

←Older revision		Revision as of 16:47, 14 August 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6rxx is ~~ON HOLD~~	+	==Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state C, Poly-Ala==
		+	<StructureSection load='6rxx' size='340' side='right'caption='[[6rxx]], [[Resolution\|resolution]] 7.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6rxx]] is a 68 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RXX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rxx OCA], [http://pdbe.org/6rxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rxx RCSB], [http://www.ebi.ac.uk/pdbsum/6rxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rxx ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/G0S3V7_CHATD G0S3V7_CHATD]] Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.[PIRNR:PIRNR006515] [[http://www.uniprot.org/uniprot/PNO1_CHATD PNO1_CHATD]] Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.[UniProtKB:Q99216] [[http://www.uniprot.org/uniprot/NOL10_CHATD NOL10_CHATD]] May be involved in rRNA-processing and ribosome biosynthesis.[UniProtKB:P48234] [[http://www.uniprot.org/uniprot/UTP11_CHATD UTP11_CHATD]] Involved in nucleolar processing of pre-18S ribosomal RNA.[UniProtKB:P34247]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Eukaryotic ribosome biogenesis involves RNA folding and processing that depend on assembly factors and small nucleolar RNAs (snoRNAs). The 90S (SSU-processome) is the earliest pre-ribosome structurally analyzed, which was suggested to assemble stepwise along the growing pre-rRNA from 5' > 3', but this directionality may not be accurate. Here, by analyzing the structure of a series of 90S assembly intermediates from Chaetomium thermophilum, we discover a reverse order of 18S rRNA subdomain incorporation. Large parts of the 18S rRNA 3' and central domains assemble first into the 90S before the 5' domain is integrated. This final incorporation depends on a contact between a heterotrimer Enp2-Bfr2-Lcp5 recruited to the flexible 5' domain and Kre33, which reconstitutes the Kre33-Enp-Brf2-Lcp5 module on the compacted 90S. Keeping the 5' domain temporarily segregated from the 90S scaffold could provide extra time to complete the multifaceted 5' domain folding, which depends on a distinct set of snoRNAs and processing factors.

-	~~Authors:~~ Cheng, J., ~~Kellner~~, N., ~~Griesel~~, S., ~~Berninghausen~~, O., ~~Beckmann~~, R., Hurt, E.	+	Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.,Cheng J, Bassler J, Fischer P, Lau B, Kellner N, Kunze R, Griesel S, Kallas M, Berninghausen O, Strauss D, Beckmann R, Hurt E Mol Cell. 2019 Jul 15. pii: S1097-2765(19)30489-7. doi:, 10.1016/j.molcel.2019.06.032. PMID:31378463<ref>PMID:31378463</ref>

-	~~Description: Cryo-EM structure~~ of the ~~90S pre~~-~~ribosome (Kre33~~-~~Noc4) from~~ Chaetomium thermophilum~~, state C, Poly-Ala~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6rxx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chaetomium thermophilum]]
		+	[[Category: Large Structures]]
		+	[[Category: Beckmann, R]]
		+	[[Category: Berninghausen, O]]
	[[Category: Cheng, J]]		[[Category: Cheng, J]]
		+	[[Category: Griesel, S]]
	[[Category: Hurt, E]]		[[Category: Hurt, E]]
	[[Category: Kellner, N]]		[[Category: Kellner, N]]
-	[[Category: ~~Berninghausen, O~~]]	+	[[Category: Ribosome]]
-	[[Category: ~~Griesel, S~~]]	+	[[Category: Ribosome biogenesis]]
-	[[Category: ~~Beckmann, R~~]]	+	[[Category: Rrna]]

OCA: Protected "6rxx" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2019 04:30:42 GMT

Protected "6rxx" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:30, 19 June 2019

OCA: New page: '''Unreleased structure''' The entry 6rxx is ON HOLD Authors: Cheng, J., Kellner, N., Griesel, S., Berninghausen, O., Beckmann, R., Hurt, E. Description: Cryo-EM structure of the 90S p...

OCA — Wed, 19 Jun 2019 04:30:40 GMT

New page: '''Unreleased structure''' The entry 6rxx is ON HOLD Authors: Cheng, J., Kellner, N., Griesel, S., Berninghausen, O., Beckmann, R., Hurt, E. Description: Cryo-EM structure of the 90S p...

New page

'''Unreleased structure'''

The entry 6rxx is ON HOLD

Authors: Cheng, J., Kellner, N., Griesel, S., Berninghausen, O., Beckmann, R., Hurt, E.

Description: Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state C, Poly-Ala
[[Category: Unreleased Structures]]
[[Category: Cheng, J]]
[[Category: Hurt, E]]
[[Category: Kellner, N]]
[[Category: Berninghausen, O]]
[[Category: Griesel, S]]
[[Category: Beckmann, R]]