6rz9 - Revision history

OCA at 12:31, 24 January 2024

OCA — Wed, 24 Jan 2024 12:31:43 GMT

←Older revision		Revision as of 12:31, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6rz9' size='340' side='right'caption='[[6rz9]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='6rz9' size='340' side='right'caption='[[6rz9]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RZ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RZ9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KO5:(2~{S})-8-[[4-[4-(5-fluoranyl-2-methyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3-dih+ydro-1,4-benzoxazine-2-carboxylic+acid'>KO5</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.73Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYSLTR2, CYSLT2, CYSLT2R, PSEC0146 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KO5:(2~{S})-8-[[4-[4-(5-fluoranyl-2-methyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3-dih+ydro-1,4-benzoxazine-2-carboxylic+acid'>KO5</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rz9 OCA], [https://pdbe.org/6rz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rz9 RCSB], [https://www.ebi.ac.uk/pdbsum/6rz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rz9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rz9 OCA], [https://pdbe.org/6rz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rz9 RCSB], [https://www.ebi.ac.uk/pdbsum/6rz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rz9 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN]] Uveal melanoma.	+	[https://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN] Uveal melanoma.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN]] Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.	+	[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN] Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Besserer-Offroy, E]]	+	[[Category: Besserer-Offroy E]]
-	[[Category: Borshchevskiy, V]]	+	[[Category: Borshchevskiy V]]
-	[[Category: Brouillette~~, R L~~]]	+	[[Category: Brouillette RL]]
-	[[Category: Cherezov, V]]	+	[[Category: Cherezov V]]
-	[[Category: Ergasheva, M]]	+	[[Category: Ergasheva M]]
-	[[Category: Fujimoto, T]]	+	[[Category: Fujimoto T]]
-	[[Category: Gordeliy, V]]	+	[[Category: Gordeliy V]]
-	[[Category: Gusach, A]]	+	[[Category: Gusach A]]
-	[[Category: Han~~, G W~~]]	+	[[Category: Han GW]]
-	[[Category: Ishchenko, A]]	+	[[Category: Ishchenko A]]
-	[[Category: Katritch, V]]	+	[[Category: Katritch V]]
-	[[Category: Kovalev, K]]	+	[[Category: Kovalev K]]
-	[[Category: Longpre~~, J M~~]]	+	[[Category: Longpre JM]]
-	[[Category: Luginina, A]]	+	[[Category: Luginina A]]
-	[[Category: Marin, E]]	+	[[Category: Marin E]]
-	[[Category: Maruyama, T]]	+	[[Category: Maruyama T]]
-	[[Category: Mishin, A]]	+	[[Category: Mishin A]]
-	[[Category: Popov, P]]	+	[[Category: Popov P]]
-	[[Category: Romanovskaya, D]]	+	[[Category: Romanovskaya D]]
-	[[Category: Sarret, P]]	+	[[Category: Sarret P]]
-	[[Category: Shevtsov, M]]	+	[[Category: Shevtsov M]]
-	[[Category: Stauch, B]]	+	[[Category: Stauch B]]
-	[[Category: Stepko, A]]	+	[[Category: Stepko A]]
-	~~[[Category: Asthma]]~~	+
-	~~[[Category: Bril]]~~	+
-	~~[[Category: Cyslt2]]~~	+
-	~~[[Category: Cyslt2r]]~~	+
-	~~[[Category: Cysltr2]]~~	+
-	~~[[Category: Cysteinyl leukotriene]]~~	+
-	~~[[Category: Cysteinyl leukotriene receptor 2]]~~	+
-	~~[[Category: Gpcr]]~~	+
-	~~[[Category: Lcp]]~~	+
-	~~[[Category: Membrane protein~~]]	+

OCA at 11:07, 30 March 2022

OCA — Wed, 30 Mar 2022 11:07:48 GMT

OCA at 13:11, 18 December 2019

OCA — Wed, 18 Dec 2019 13:11:30 GMT

←Older revision		Revision as of 13:11, 18 December 2019
Line 3:		Line 3:
	<StructureSection load='6rz9' size='340' side='right'caption='[[6rz9]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='6rz9' size='340' side='right'caption='[[6rz9]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rz9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rz9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZ9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KO5:(2~{S})-8-[[4-[4-(5-fluoranyl-2-methyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3-dihydro-1,4-benzoxazine-2-carboxylic+acid'>KO5</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KO5:(2~{S})-8-[[4-[4-(5-fluoranyl-2-methyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3-dihydro-1,4-benzoxazine-2-carboxylic+acid'>KO5</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYSLTR2, CYSLT2, CYSLT2R, PSEC0146 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rz9 OCA], [http://pdbe.org/6rz9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rz9 RCSB], [http://www.ebi.ac.uk/pdbsum/6rz9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rz9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rz9 OCA], [http://pdbe.org/6rz9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rz9 RCSB], [http://www.ebi.ac.uk/pdbsum/6rz9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rz9 ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN]] Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.		[[http://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN]] Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. While selective inhibition of CysLT1R has been used for treating asthma and associated diseases for over two decades, CysLT2R has recently started to emerge as a potential drug target against atopic asthma, brain injury and central nervous system disorders, as well as several types of cancer. Here, we describe four crystal structures of CysLT2R in complex with three dual CysLT1R/CysLT2R antagonists. The reported structures together with the results of comprehensive mutagenesis and computer modeling studies shed light on molecular determinants of CysLTR ligand selectivity and specific effects of disease-related single nucleotide variants.
		+
		+	Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.,Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy E, Longpre JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V Nat Commun. 2019 Dec 6;10(1):5573. doi: 10.1038/s41467-019-13348-2. PMID:31811124<ref>PMID:31811124</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6rz9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Besserer-Offroy, E]]		[[Category: Besserer-Offroy, E]]

OCA at 15:22, 11 December 2019

OCA — Wed, 11 Dec 2019 15:22:06 GMT

←Older revision		Revision as of 15:22, 11 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6rz9 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2770372==
-		+	<StructureSection load='6rz9' size='340' side='right'caption='[[6rz9]], [[Resolution\|resolution]] 2.73Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6rz9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZ9 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KO5:(2~{S})-8-[[4-[4-(5-fluoranyl-2-methyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3-dihydro-1,4-benzoxazine-2-carboxylic+acid'>KO5</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rz9 OCA], [http://pdbe.org/6rz9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rz9 RCSB], [http://www.ebi.ac.uk/pdbsum/6rz9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rz9 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN]] Uveal melanoma.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN]] Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Besserer-Offroy, E]]
		+	[[Category: Borshchevskiy, V]]
		+	[[Category: Brouillette, R L]]
		+	[[Category: Cherezov, V]]
		+	[[Category: Ergasheva, M]]
		+	[[Category: Fujimoto, T]]
		+	[[Category: Gordeliy, V]]
		+	[[Category: Gusach, A]]
		+	[[Category: Han, G W]]
		+	[[Category: Ishchenko, A]]
		+	[[Category: Katritch, V]]
		+	[[Category: Kovalev, K]]
		+	[[Category: Longpre, J M]]
		+	[[Category: Luginina, A]]
		+	[[Category: Marin, E]]
		+	[[Category: Maruyama, T]]
		+	[[Category: Mishin, A]]
		+	[[Category: Popov, P]]
		+	[[Category: Romanovskaya, D]]
		+	[[Category: Sarret, P]]
		+	[[Category: Shevtsov, M]]
		+	[[Category: Stauch, B]]
		+	[[Category: Stepko, A]]
		+	[[Category: Asthma]]
		+	[[Category: Bril]]
		+	[[Category: Cyslt2]]
		+	[[Category: Cyslt2r]]
		+	[[Category: Cysltr2]]
		+	[[Category: Cysteinyl leukotriene]]
		+	[[Category: Cysteinyl leukotriene receptor 2]]
		+	[[Category: Gpcr]]
		+	[[Category: Lcp]]
		+	[[Category: Membrane protein]]

OCA at 04:39, 24 July 2019

OCA — Wed, 24 Jul 2019 04:39:13 GMT

←Older revision		Revision as of 04:39, 24 July 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6rz9 is ON HOLD	+	The entry 6rz9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6rz9" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2019 04:34:15 GMT

Protected "6rz9" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:34, 19 June 2019

OCA: New page: '''Unreleased structure''' The entry 6rz9 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Jun 2019 04:34:13 GMT

New page: '''Unreleased structure''' The entry 6rz9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6rz9 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

←Older revision		Revision as of 11:07, 30 March 2022
Line 3:		Line 3:
	<StructureSection load='6rz9' size='340' side='right'caption='[[6rz9]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='6rz9' size='340' side='right'caption='[[6rz9]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rz9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZ9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RZ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RZ9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KO5:(2~{S})-8-[[4-[4-(5-fluoranyl-2-methyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3-~~dihydro~~-1,4-benzoxazine-2-carboxylic+acid'>KO5</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KO5:(2~{S})-8-[[4-[4-(5-fluoranyl-2-methyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3-dih+ydro-1,4-benzoxazine-2-carboxylic+acid'>KO5</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYSLTR2, CYSLT2, CYSLT2R, PSEC0146 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYSLTR2, CYSLT2, CYSLT2R, PSEC0146 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rz9 OCA], [~~http~~://pdbe.org/6rz9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rz9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rz9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rz9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rz9 OCA], [https://pdbe.org/6rz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rz9 RCSB], [https://www.ebi.ac.uk/pdbsum/6rz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rz9 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN]] Uveal melanoma.	+	[[https://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN]] Uveal melanoma.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN]] Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.	+	[[https://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN]] Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==