6rze - Revision history

OCA at 12:31, 24 January 2024

OCA — Wed, 24 Jan 2024 12:31:48 GMT

←Older revision		Revision as of 12:31, 24 January 2024
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	<StructureSection load='6rze' size='340' side='right'caption='[[6rze]], [[Resolution\|resolution]] 1.69Å' scene=''>		<StructureSection load='6rze' size='340' side='right'caption='[[6rze]], [[Resolution\|resolution]] 1.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rze]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RZE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rze]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RZE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CL:CHLORIDE+ION'>CL</scene~~>, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.69Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">adk, D9E35_07195, D9H53_18240, D9H70_06005, D9I87_03740, EB509_06410, EB510_02065, EB515_08900, EC382_09075, ED225_07155, ED607_06260, ED611_06205, ED903_02730, ED944_09135, EEA45_02410, EF173_11005, EIA21_12240, NCTC10444_03756, NCTC9112_04001, NCTC9119_03910, NCTC9969_03944, SAMEA3472056_03545, SAMEA3485101_03900, SAMEA3485113_01288 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~562~~ "~~Bacillus coli~~" ~~Migula 1895])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rze OCA], [https://pdbe.org/6rze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rze RCSB], [https://www.ebi.ac.uk/pdbsum/6rze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rze ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rze OCA], [~~http~~://pdbe.org/6rze PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rze RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rze PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rze ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~A0A234NPI7_ECOLX A0A234NPI7_ECOLX]~~] Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. ~~Plays an important role~~ in ~~cellular~~ energy ~~homeostasis~~ and ~~in adenine~~ nucleotide ~~metabolism~~.[HAMAP-Rule:MF_00235]	+	[https://www.uniprot.org/uniprot/KAD_ECOLI KAD_ECOLI] Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth.[HAMAP-Rule:MF_00235]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6rze" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6rze" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Adenylate kinase 3D structures\|Adenylate kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: Adenylate kinase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Grundstrom, C]]	+	[[Category: Grundstrom C]]
-	[[Category: Rogne, P]]	+	[[Category: Rogne P]]
-	[[Category: Sauer-Eriksson~~, A E~~]]	+	[[Category: Sauer-Eriksson AE]]
-	[[Category: Wolf-Watz, M]]	+	[[Category: Wolf-Watz M]]
-	~~[[Category: R119a variant]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:55, 21 August 2019

OCA — Wed, 21 Aug 2019 06:55:51 GMT

←Older revision		Revision as of 06:55, 21 August 2019
Line 3:		Line 3:
	<StructureSection load='6rze' size='340' side='right'caption='[[6rze]], [[Resolution\|resolution]] 1.69Å' scene=''>		<StructureSection load='6rze' size='340' side='right'caption='[[6rze]], [[Resolution\|resolution]] 1.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rze]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rze]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">adk, D9E35_07195, D9H53_18240, D9H70_06005, D9I87_03740, EB509_06410, EB510_02065, EB515_08900, EC382_09075, ED225_07155, ED607_06260, ED611_06205, ED903_02730, ED944_09135, EEA45_02410, EF173_11005, EIA21_12240, NCTC10444_03756, NCTC9112_04001, NCTC9119_03910, NCTC9969_03944, SAMEA3472056_03545, SAMEA3485101_03900, SAMEA3485113_01288 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rze OCA], [http://pdbe.org/6rze PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rze RCSB], [http://www.ebi.ac.uk/pdbsum/6rze PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rze ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rze OCA], [http://pdbe.org/6rze PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rze RCSB], [http://www.ebi.ac.uk/pdbsum/6rze PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rze ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Adenylate kinase]]		[[Category: Adenylate kinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 06:06, 7 August 2019

OCA — Wed, 07 Aug 2019 06:06:55 GMT

←Older revision		Revision as of 06:06, 7 August 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6rze is ~~ON HOLD~~	+	==Crystal structure of E. coli Adenylate kinase R119A mutant==
		+	<StructureSection load='6rze' size='340' side='right'caption='[[6rze]], [[Resolution\|resolution]] 1.69Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6rze]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZE FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rze OCA], [http://pdbe.org/6rze PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rze RCSB], [http://www.ebi.ac.uk/pdbsum/6rze PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rze ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0A234NPI7_ECOLX A0A234NPI7_ECOLX]] Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.[HAMAP-Rule:MF_00235]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	As a key molecule in biology, adenosine triphosphate (ATP) has numerous crucial functions in, for instance, energetics, post-translational modifications, nucleotide biosynthesis, and cofactor metabolism. Here, we have discovered an intricate interplay between the enzyme adenylate kinase and its substrate ATP. The side chain of an arginine residue was found to be an efficient sensor of the aromatic moiety of ATP through the formation of a strong cation-pi interaction. In addition to recognition, the interaction was found to have dual functionality. First, it nucleates the activating conformational transition of the ATP binding domain and also affects the specificity in the distant AMP binding domain. In light of the functional consequences resulting from the cation-pi interaction, it is possible that the mode of ATP recognition may be a useful tool in enzyme design.

-	~~Authors~~:	+	Nucleation of an Activating Conformational Change by a Cation-pi Interaction.,Rogne P, Andersson D, Grundstrom C, Sauer-Eriksson E, Linusson A, Wolf-Watz M Biochemistry. 2019 Jul 29. doi: 10.1021/acs.biochem.9b00538. PMID:31339702<ref>PMID:31339702</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6rze" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Adenylate kinase]]
		+	[[Category: Large Structures]]
		+	[[Category: Grundstrom, C]]
		+	[[Category: Rogne, P]]
		+	[[Category: Sauer-Eriksson, A E]]
		+	[[Category: Wolf-Watz, M]]
		+	[[Category: R119a variant]]
		+	[[Category: Transferase]]

OCA: Protected "6rze" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2019 04:34:33 GMT

Protected "6rze" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:34, 19 June 2019

OCA: New page: '''Unreleased structure''' The entry 6rze is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Jun 2019 04:34:32 GMT

New page: '''Unreleased structure''' The entry 6rze is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6rze is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]