6rzq - Revision history

OCA at 12:32, 24 January 2024

OCA — Wed, 24 Jan 2024 12:32:03 GMT

←Older revision		Revision as of 12:32, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6rzq' size='340' side='right'caption='[[6rzq]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='6rzq' size='340' side='right'caption='[[6rzq]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rzq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RZQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rzq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RZQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID~~-~~ADENYLATE+ESTER'>ANP</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.81Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">PF3D7_0831700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzq OCA], [https://pdbe.org/6rzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rzq RCSB], [https://www.ebi.ac.uk/pdbsum/6rzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzq OCA], [~~http~~://pdbe.org/6rzq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rzq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rzq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzq ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/K7NTP5_PLAF7 K7NTP5_PLAF7]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6rzq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6rzq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plaf7~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: Day, J]]	+	[[Category: Day J]]
-	[[Category: Vakonakis, I]]	+	[[Category: Vakonakis I]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Malaria exported chaperone intra-erythrocytic amp-pnp~~]]	+

OCA at 11:50, 13 November 2019

OCA — Wed, 13 Nov 2019 11:50:51 GMT

←Older revision		Revision as of 11:50, 13 November 2019
Line 3:		Line 3:
	<StructureSection load='6rzq' size='340' side='right'caption='[[6rzq]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='6rzq' size='340' side='right'caption='[[6rzq]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rzq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rzq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PF3D7_0831700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzq OCA], [http://pdbe.org/6rzq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rzq RCSB], [http://www.ebi.ac.uk/pdbsum/6rzq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzq OCA], [http://pdbe.org/6rzq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rzq RCSB], [http://www.ebi.ac.uk/pdbsum/6rzq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzq ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plasmodium falciparum is the most lethal of human-infective malaria parasites. A hallmark of P. falciparum malaria is extensive remodeling of host erythrocytes by the parasite, which facilitates the development of virulence properties such as host cell adhesion to the endothelial lining of the microvasculature. Host remodeling is mediated by a large complement of parasite proteins exported to the erythrocyte; among them is a single heat shock protein (Hsp)70-class protein chaperone, P. falciparum Hsp70-x (PfHsp70-x). PfHsp70-x was previously shown to assist the development of virulent cytoadherence characteristics. Here, we show that PfHsp70-x also supports parasite growth under elevated temperature conditions that simulate febrile episodes, especially at the beginning of the parasite life cycle when most of host cell remodeling takes place. Biochemical and biophysical analyses of PfHsp70-x, including crystallographic structures of its catalytic domain and the J-domain of its stimulatory Hsp40 cochaperone, suggest that PfHsp70-x is highly similar to human Hsp70 chaperones endogenous to the erythrocyte. Nevertheless, our results indicate that selective inhibition of PfHsp70-x function using small molecules may be possible and highlight specific sites of its catalytic domain as potentially of high interest. We discuss the likely roles of PfHsp70-x and human chaperones in P. falciparum biology and how specific inhibitors may assist us in disentangling their relative contributions.-Day, J., Passecker, A., Beck, H.-P., Vakonakis, I. The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite.
		+
		+	The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite.,Day J, Passecker A, Beck HP, Vakonakis I FASEB J. 2019 Nov 5:fj201901741R. doi: 10.1096/fj.201901741R. PMID:31690116<ref>PMID:31690116</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6rzq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Plaf7]]
	[[Category: Day, J]]		[[Category: Day, J]]
	[[Category: Vakonakis, I]]		[[Category: Vakonakis, I]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Malaria exported chaperone intra-erythrocytic amp-pnp]]		[[Category: Malaria exported chaperone intra-erythrocytic amp-pnp]]

OCA at 10:41, 2 October 2019

OCA — Wed, 02 Oct 2019 10:41:58 GMT

←Older revision		Revision as of 10:41, 2 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6rzq is ON HOLD until Paper Publication~~	+	==Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ANP-PnP bound state==
-		+	<StructureSection load='6rzq' size='340' side='right'caption='[[6rzq]], [[Resolution\|resolution]] 1.81Å' scene=''>
-	~~Authors: Vakonakis, I., Day, J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6rzq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZQ FirstGlance]. <br>
-	~~Description:~~ Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain -ANP-PnP bound state	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzq OCA], [http://pdbe.org/6rzq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rzq RCSB], [http://www.ebi.ac.uk/pdbsum/6rzq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzq ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Day, J]]		[[Category: Day, J]]
	[[Category: Vakonakis, I]]		[[Category: Vakonakis, I]]
		+	[[Category: Chaperone]]
		+	[[Category: Malaria exported chaperone intra-erythrocytic amp-pnp]]

OCA at 05:24, 26 June 2019

OCA — Wed, 26 Jun 2019 05:24:50 GMT

←Older revision		Revision as of 05:24, 26 June 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6rzq is ON HOLD	+	The entry 6rzq is ON HOLD until Paper Publication

	Authors: Vakonakis, I., Day, J.		Authors: Vakonakis, I., Day, J.

-	Description: Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain	+	Description: Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain -ANP-PnP bound state
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Day, J]]		[[Category: Day, J]]
	[[Category: Vakonakis, I]]		[[Category: Vakonakis, I]]

OCA: Protected "6rzq" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2019 04:35:29 GMT

Protected "6rzq" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:35, 19 June 2019

OCA: New page: '''Unreleased structure''' The entry 6rzq is ON HOLD Authors: Vakonakis, I., Day, J. Description: Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain [[Category: Unreleas...

OCA — Wed, 19 Jun 2019 04:35:27 GMT

New page: '''Unreleased structure''' The entry 6rzq is ON HOLD Authors: Vakonakis, I., Day, J. Description: Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain [[Category: Unreleas...

New page

'''Unreleased structure'''

The entry 6rzq is ON HOLD

Authors: Vakonakis, I., Day, J.

Description: Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain
[[Category: Unreleased Structures]]
[[Category: Day, J]]
[[Category: Vakonakis, I]]