6rzt - Revision history

OCA at 05:57, 11 April 2020

OCA — Sat, 11 Apr 2020 05:57:03 GMT

←Older revision		Revision as of 05:57, 11 April 2020
Line 3:		Line 3:
	<SX load='6rzt' size='340' side='right' viewer='molstar' caption='[[6rzt]], [[Resolution\|resolution]] 14.70Å' scene=''>		<SX load='6rzt' size='340' side='right' viewer='molstar' caption='[[6rzt]], [[Resolution\|resolution]] 14.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rzt]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_144.50 Cbs 144.50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rzt]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_144.50 Cbs 144.50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RZT FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0065850 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=209285 CBS 144.50])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0065850 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=209285 CBS 144.50])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzt OCA], [http://pdbe.org/6rzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rzt RCSB], [http://www.ebi.ac.uk/pdbsum/6rzt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzt OCA], [http://pdbe.org/6rzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rzt RCSB], [http://www.ebi.ac.uk/pdbsum/6rzt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:38, 7 March 2020

OCA — Sat, 07 Mar 2020 00:38:46 GMT

←Older revision		Revision as of 00:38, 7 March 2020
Line 1:		Line 1:

	==Structure of s-Mgm1 decorating the outer surface of tubulated lipid membranes==		==Structure of s-Mgm1 decorating the outer surface of tubulated lipid membranes==
-	<~~StructureSection~~ load='6rzt' size='340' side='right'caption='[[6rzt]], [[Resolution\|resolution]] 14.70Å' scene=''>	+	<SX load='6rzt' size='340' side='right' viewer='molstar' caption='[[6rzt]], [[Resolution\|resolution]] 14.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6rzt]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_144.50 Cbs 144.50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZT FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rzt]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_144.50 Cbs 144.50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZT FirstGlance]. <br>
Line 19:		Line 19:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Cbs 144 50]]		[[Category: Cbs 144 50]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 07:07, 31 July 2019

OCA — Wed, 31 Jul 2019 07:07:20 GMT

←Older revision		Revision as of 07:07, 31 July 2019
Line 3:		Line 3:
	<StructureSection load='6rzt' size='340' side='right'caption='[[6rzt]], [[Resolution\|resolution]] 14.70Å' scene=''>		<StructureSection load='6rzt' size='340' side='right'caption='[[6rzt]], [[Resolution\|resolution]] 14.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rzt]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rzt]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_144.50 Cbs 144.50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzt OCA], [http://pdbe.org/6rzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rzt RCSB], [http://www.ebi.ac.uk/pdbsum/6rzt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzt ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0065850 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=209285 CBS 144.50])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzt OCA], [http://pdbe.org/6rzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rzt RCSB], [http://www.ebi.ac.uk/pdbsum/6rzt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cbs 144 50]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Daumke, O]]		[[Category: Daumke, O]]

OCA at 06:29, 24 July 2019

OCA — Wed, 24 Jul 2019 06:29:33 GMT

←Older revision		Revision as of 06:29, 24 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6rzt is ~~ON HOLD until Paper~~ Publication	+	==Structure of s-Mgm1 decorating the outer surface of tubulated lipid membranes==
		+	<StructureSection load='6rzt' size='340' side='right'caption='[[6rzt]], [[Resolution\|resolution]] 14.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6rzt]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZT FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzt OCA], [http://pdbe.org/6rzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rzt RCSB], [http://www.ebi.ac.uk/pdbsum/6rzt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzt ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Balanced fusion and fission are key for the proper function and physiology of mitochondria(1,2). Remodelling of the mitochondrial inner membrane is mediated by the dynamin-like protein mitochondrial genome maintenance 1 (Mgm1) in fungi or the related protein optic atrophy 1 (OPA1) in animals(3-5). Mgm1 is required for the preservation of mitochondrial DNA in yeast(6), whereas mutations in the OPA1 gene in humans are a common cause of autosomal dominant optic atrophy-a genetic disorder that affects the optic nerve(7,8). Mgm1 and OPA1 are present in mitochondria as a membrane-integral long form and a short form that is soluble in the intermembrane space. Yeast strains that express temperature-sensitive mutants of Mgm1(9,10) or mammalian cells that lack OPA1 display fragmented mitochondria(11,12), which suggests that Mgm1 and OPA1 have an important role in inner-membrane fusion. Consistently, only the mitochondrial outer membrane-not the inner membrane-fuses in the absence of functional Mgm1(13). Mgm1 and OPA1 have also been shown to maintain proper cristae architecture(10,14); for example, OPA1 prevents the release of pro-apoptotic factors by tightening crista junctions(15). Finally, the short form of OPA1 localizes to mitochondrial constriction sites, where it presumably promotes mitochondrial fission(16). How Mgm1 and OPA1 perform their diverse functions in membrane fusion, scission and cristae organization is at present unknown. Here we present crystal and electron cryo-tomography structures of Mgm1 from Chaetomium thermophilum. Mgm1 consists of a GTPase (G) domain, a bundle signalling element domain, a stalk, and a paddle domain that contains a membrane-binding site. Biochemical and cell-based experiments demonstrate that the Mgm1 stalk mediates the assembly of bent tetramers into helical filaments. Electron cryo-tomography studies of Mgm1-decorated lipid tubes and fluorescence microscopy experiments on reconstituted membrane tubes indicate how the tetramers assemble on positively or negatively curved membranes. Our findings convey how Mgm1 and OPA1 filaments dynamically remodel the mitochondrial inner membrane.

-	~~Authors:~~ Faelber, K., Dietrich, L., Noel, ~~J.K.~~, ~~Sanchez~~, R., Kudryashev, M., ~~Kuehlbrandt~~, W., Daumke, O.	+	Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.,Faelber K, Dietrich L, Noel JK, Wollweber F, Pfitzner AK, Muhleip A, Sanchez R, Kudryashev M, Chiaruttini N, Lilie H, Schlegel J, Rosenbaum E, Hessenberger M, Matthaeus C, Kunz S, von der Malsburg A, Noe F, Roux A, van der Laan M, Kuhlbrandt W, Daumke O Nature. 2019 Jul;571(7765):429-433. doi: 10.1038/s41586-019-1372-3. Epub 2019 Jul, 10. PMID:31292547<ref>PMID:31292547</ref>

-	~~Description: Structure~~ of ~~s-Mgm1 decorating~~ the ~~outer surface~~ of ~~tubulated lipid membranes~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6rzt" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Daumke, O]]
		+	[[Category: Dietrich, L]]
	[[Category: Faelber, K]]		[[Category: Faelber, K]]
	[[Category: Kudryashev, M]]		[[Category: Kudryashev, M]]
-	[[Category: Dietrich, L]]
-	[[Category: Sanchez, R]]
-	[[Category: Daumke, O]]
-	[[Category: Noel, J.K]]
	[[Category: Kuehlbrandt, W]]		[[Category: Kuehlbrandt, W]]
		+	[[Category: Noel, J K]]
		+	[[Category: Sanchez, R]]
		+	[[Category: Contractile protein]]
		+	[[Category: Gtpase]]
		+	[[Category: Membrane remodelling]]
		+	[[Category: Mitochondrial dynamic]]
		+	[[Category: Mitochondrial protein]]
		+	[[Category: Subtomogram averaging]]

OCA at 04:27, 3 July 2019

OCA — Wed, 03 Jul 2019 04:27:28 GMT

←Older revision		Revision as of 04:27, 3 July 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6rzt is ON HOLD	+	The entry 6rzt is ON HOLD until Paper Publication

	Authors: Faelber, K., Dietrich, L., Noel, J.K., Sanchez, R., Kudryashev, M., Kuehlbrandt, W., Daumke, O.		Authors: Faelber, K., Dietrich, L., Noel, J.K., Sanchez, R., Kudryashev, M., Kuehlbrandt, W., Daumke, O.
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	Description: Structure of s-Mgm1 decorating the outer surface of tubulated lipid membranes		Description: Structure of s-Mgm1 decorating the outer surface of tubulated lipid membranes
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Dietrich, L]]
-	[[Category: Sanchez, R]]
	[[Category: Faelber, K]]		[[Category: Faelber, K]]
	[[Category: Kudryashev, M]]		[[Category: Kudryashev, M]]
		+	[[Category: Dietrich, L]]
		+	[[Category: Sanchez, R]]
	[[Category: Daumke, O]]		[[Category: Daumke, O]]
	[[Category: Noel, J.K]]		[[Category: Noel, J.K]]
	[[Category: Kuehlbrandt, W]]		[[Category: Kuehlbrandt, W]]

OCA: Protected "6rzt" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2019 04:35:41 GMT

Protected "6rzt" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:35, 19 June 2019

OCA: New page: '''Unreleased structure''' The entry 6rzt is ON HOLD Authors: Faelber, K., Dietrich, L., Noel, J.K., Sanchez, R., Kudryashev, M., Kuehlbrandt, W., Daumke, O. Description: Structure of ...

OCA — Wed, 19 Jun 2019 04:35:40 GMT

New page: '''Unreleased structure''' The entry 6rzt is ON HOLD Authors: Faelber, K., Dietrich, L., Noel, J.K., Sanchez, R., Kudryashev, M., Kuehlbrandt, W., Daumke, O. Description: Structure of ...

New page

'''Unreleased structure'''

The entry 6rzt is ON HOLD

Authors: Faelber, K., Dietrich, L., Noel, J.K., Sanchez, R., Kudryashev, M., Kuehlbrandt, W., Daumke, O.

Description: Structure of s-Mgm1 decorating the outer surface of tubulated lipid membranes
[[Category: Unreleased Structures]]
[[Category: Dietrich, L]]
[[Category: Sanchez, R]]
[[Category: Faelber, K]]
[[Category: Kudryashev, M]]
[[Category: Daumke, O]]
[[Category: Noel, J.K]]
[[Category: Kuehlbrandt, W]]