6rzy - Revision history

OCA at 12:32, 24 January 2024

OCA — Wed, 24 Jan 2024 12:32:08 GMT

←Older revision		Revision as of 12:32, 24 January 2024
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	<StructureSection load='6rzy' size='340' side='right'caption='[[6rzy]], [[Resolution\|resolution]] 1.38Å' scene=''>		<StructureSection load='6rzy' size='340' side='right'caption='[[6rzy]], [[Resolution\|resolution]] 1.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rzy]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RZY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rzy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RZY FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PF3D7_0113700 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=36329 PLAF7])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.379Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzy OCA], [~~http~~://pdbe.org/6rzy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rzy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rzy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzy OCA], [https://pdbe.org/6rzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rzy RCSB], [https://www.ebi.ac.uk/pdbsum/6rzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8I2E1_PLAF7 Q8I2E1_PLAF7]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 6rzy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6rzy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plaf7~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: Day, J]]	+	[[Category: Day J]]
-	[[Category: Vakonakis, I]]	+	[[Category: Vakonakis I]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Malaria exported co-chaperone intra-erythrocytic~~]]	+

OCA at 11:50, 13 November 2019

OCA — Wed, 13 Nov 2019 11:50:50 GMT

←Older revision		Revision as of 11:50, 13 November 2019
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	<StructureSection load='6rzy' size='340' side='right'caption='[[6rzy]], [[Resolution\|resolution]] 1.38Å' scene=''>		<StructureSection load='6rzy' size='340' side='right'caption='[[6rzy]], [[Resolution\|resolution]] 1.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rzy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rzy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzy OCA], [http://pdbe.org/6rzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rzy RCSB], [http://www.ebi.ac.uk/pdbsum/6rzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzy ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PF3D7_0113700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzy OCA], [http://pdbe.org/6rzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rzy RCSB], [http://www.ebi.ac.uk/pdbsum/6rzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzy ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plasmodium falciparum is the most lethal of human-infective malaria parasites. A hallmark of P. falciparum malaria is extensive remodeling of host erythrocytes by the parasite, which facilitates the development of virulence properties such as host cell adhesion to the endothelial lining of the microvasculature. Host remodeling is mediated by a large complement of parasite proteins exported to the erythrocyte; among them is a single heat shock protein (Hsp)70-class protein chaperone, P. falciparum Hsp70-x (PfHsp70-x). PfHsp70-x was previously shown to assist the development of virulent cytoadherence characteristics. Here, we show that PfHsp70-x also supports parasite growth under elevated temperature conditions that simulate febrile episodes, especially at the beginning of the parasite life cycle when most of host cell remodeling takes place. Biochemical and biophysical analyses of PfHsp70-x, including crystallographic structures of its catalytic domain and the J-domain of its stimulatory Hsp40 cochaperone, suggest that PfHsp70-x is highly similar to human Hsp70 chaperones endogenous to the erythrocyte. Nevertheless, our results indicate that selective inhibition of PfHsp70-x function using small molecules may be possible and highlight specific sites of its catalytic domain as potentially of high interest. We discuss the likely roles of PfHsp70-x and human chaperones in P. falciparum biology and how specific inhibitors may assist us in disentangling their relative contributions.-Day, J., Passecker, A., Beck, H.-P., Vakonakis, I. The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite.
		+
		+	The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite.,Day J, Passecker A, Beck HP, Vakonakis I FASEB J. 2019 Nov 5:fj201901741R. doi: 10.1096/fj.201901741R. PMID:31690116<ref>PMID:31690116</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6rzy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Plaf7]]
	[[Category: Day, J]]		[[Category: Day, J]]
	[[Category: Vakonakis, I]]		[[Category: Vakonakis, I]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Malaria exported co-chaperone intra-erythrocytic]]		[[Category: Malaria exported co-chaperone intra-erythrocytic]]

OCA at 10:41, 2 October 2019

OCA — Wed, 02 Oct 2019 10:41:57 GMT

←Older revision		Revision as of 10:41, 2 October 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6rzy ~~is ON HOLD until Paper Publication~~	+	==Plasmodium falciparum PFA0660w Hsp40 co-chaperone J-domain==
-		+	<StructureSection load='6rzy' size='340' side='right'caption='[[6rzy]], [[Resolution\|resolution]] 1.38Å' scene=''>
-	~~Authors~~: ~~Vakonakis~~, I., ~~Day~~, J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6rzy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZY FirstGlance]. <br>
-	~~Description~~: ~~Plasmodium falciparum PFA0660w Hsp40 co~~-~~chaperone J-domain~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rzy OCA], [http://pdbe.org/6rzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rzy RCSB], [http://www.ebi.ac.uk/pdbsum/6rzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rzy ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Day, J]]		[[Category: Day, J]]
	[[Category: Vakonakis, I]]		[[Category: Vakonakis, I]]
		+	[[Category: Chaperone]]
		+	[[Category: Malaria exported co-chaperone intra-erythrocytic]]

OCA at 05:24, 26 June 2019

OCA — Wed, 26 Jun 2019 05:24:54 GMT

←Older revision		Revision as of 05:24, 26 June 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6rzy is ON HOLD	+	The entry 6rzy is ON HOLD until Paper Publication

	Authors: Vakonakis, I., Day, J.		Authors: Vakonakis, I., Day, J.

OCA: Protected "6rzy" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2019 04:36:13 GMT

Protected "6rzy" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:36, 19 June 2019

OCA: New page: '''Unreleased structure''' The entry 6rzy is ON HOLD Authors: Vakonakis, I., Day, J. Description: Plasmodium falciparum PFA0660w Hsp40 co-chaperone J-domain [[Category: Unreleased Stru...

OCA — Wed, 19 Jun 2019 04:36:12 GMT

New page: '''Unreleased structure''' The entry 6rzy is ON HOLD Authors: Vakonakis, I., Day, J. Description: Plasmodium falciparum PFA0660w Hsp40 co-chaperone J-domain [[Category: Unreleased Stru...

New page

'''Unreleased structure'''

The entry 6rzy is ON HOLD

Authors: Vakonakis, I., Day, J.

Description: Plasmodium falciparum PFA0660w Hsp40 co-chaperone J-domain
[[Category: Unreleased Structures]]
[[Category: Day, J]]
[[Category: Vakonakis, I]]