6s3q - Revision history

OCA at 10:14, 22 May 2024

OCA — Wed, 22 May 2024 10:14:06 GMT

←Older revision		Revision as of 10:14, 22 May 2024
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	==Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with TFB-TBOA==		==Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with TFB-TBOA==
-	<StructureSection load='6s3q' size='340' side='right'caption='[[6s3q]]' scene=''>	+	<StructureSection load='6s3q' size='340' side='right'caption='[[6s3q]], [[Resolution\|resolution]] 3.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S3Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6S3Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6s3q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S3Q FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6s3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s3q OCA], [~~http~~://pdbe.org/6s3q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6s3q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6s3q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6s3q ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.34Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7O9:(2~{S},3~{S})-2-AZANYL-3-[[3-[[4-(TRIFLUOROMETHYL)PHENYL]CARBONYLAMINO]PHENYL]METHOXY]BUTANEDIOIC+ACID'>7O9</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s3q OCA], [https://pdbe.org/6s3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s3q RCSB], [https://www.ebi.ac.uk/pdbsum/6s3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s3q ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/EAA3_HUMAN EAA3_HUMAN] Hot water reflex epilepsy;Dicarboxylic aminoaciduria. The disease is caused by variants affecting the gene represented in this entry. Disease susceptibility is associated with variants affecting the gene represented in this entry. A deletion at the chromosome 9p24.2 locus, including SLC1A1, has been identified in patients with psychotic disorders (PubMed:21982423). This 84 kb deletion is immediately upstream of the SLC1A1 gene in a regulatory region that contains the full native promoter sequence, extends through exon 1 of the SLC1A1 mRNA, co-segregates with disease in an extended 5-generation pedigree and increases disease risk more than 18-fold for family members (PubMed:23341099).<ref>PMID:21982423</ref> <ref>PMID:23341099</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/EAA3_HUMAN EAA3_HUMAN] Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949, PubMed:33658209). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:33658209). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity).[UniProtKB:P51906][UniProtKB:P51907]<ref>PMID:21123949</ref> <ref>PMID:26690923</ref> <ref>PMID:33658209</ref> <ref>PMID:7521911</ref> <ref>PMID:7914198</ref> <ref>PMID:8857541</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith CH]]		[[Category: Arrowsmith CH]]

OCA at 14:04, 8 July 2020

OCA — Wed, 08 Jul 2020 14:04:06 GMT

←Older revision		Revision as of 14:04, 8 July 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6s3q is ~~ON HOLD until Paper Publication~~	+	==Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with TFB-TBOA==
-		+	<StructureSection load='6s3q' size='340' side='right'caption='[[6s3q]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S3Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6S3Q FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6s3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s3q OCA], [http://pdbe.org/6s3q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s3q RCSB], [http://www.ebi.ac.uk/pdbsum/6s3q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s3q ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Arrowsmith CH]]
		+	[[Category: Baronina A]]
		+	[[Category: Borkowska O]]
		+	[[Category: Bountra C]]
		+	[[Category: Burgess-Brown NA]]
		+	[[Category: Carpenter EP]]
		+	[[Category: Chalk R]]
		+	[[Category: Chu A]]
		+	[[Category: Dong YY]]
		+	[[Category: Edwards AM]]
		+	[[Category: Han S]]
		+	[[Category: Mukhopadhyay S]]
		+	[[Category: Pike ACW]]
		+	[[Category: Rotty B]]
		+	[[Category: Shintre CA]]
		+	[[Category: Shrestha L]]
		+	[[Category: Tessitore A]]
		+	[[Category: Venkaya S]]
		+	[[Category: Yu X]]

OCA at 04:53, 31 July 2019

OCA — Wed, 31 Jul 2019 04:53:25 GMT

←Older revision		Revision as of 04:53, 31 July 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6s3q is ON HOLD	+	The entry 6s3q is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6s3q" [edit=sysop:move=sysop]

OCA — Wed, 03 Jul 2019 04:32:54 GMT

Protected "6s3q" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:32, 3 July 2019

OCA: New page: '''Unreleased structure''' The entry 6s3q is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Jul 2019 04:32:52 GMT

New page: '''Unreleased structure''' The entry 6s3q is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6s3q is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]