6s4c - Revision history

OCA at 12:35, 24 January 2024

OCA — Wed, 24 Jan 2024 12:35:07 GMT

←Older revision		Revision as of 12:35, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6s4c' size='340' side='right'caption='[[6s4c]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6s4c' size='340' side='right'caption='[[6s4c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6s4c]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S4C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6S4C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6s4c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S4C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Col7a1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6s4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s4c OCA], [~~http~~://pdbe.org/6s4c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6s4c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6s4c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6s4c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s4c OCA], [https://pdbe.org/6s4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s4c RCSB], [https://www.ebi.ac.uk/pdbsum/6s4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s4c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CO7A1_MOUSE CO7A1_MOUSE]] Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.[UniProtKB:Q02388]<ref>PMID:10523500</ref>	+	[https://www.uniprot.org/uniprot/CO7A1_MOUSE CO7A1_MOUSE] Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.[UniProtKB:Q02388]<ref>PMID:10523500</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6s4c" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6s4c" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Collagen 3D structures\|Collagen 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Baumann, U]]	+	[[Category: Baumann U]]
-	[[Category: Flachsenberg, F]]	+	[[Category: Flachsenberg F]]
-	[[Category: Gebauer~~, J M~~]]	+	[[Category: Gebauer JM]]
-	[[Category: Seeger, K]]	+	[[Category: Seeger K]]
-	~~[[Category: Collagen vii]]~~	+
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Vwa]]~~	+
-	~~[[Category: Vwfa~~]]	+

OCA at 07:16, 15 April 2020

OCA — Wed, 15 Apr 2020 07:16:42 GMT

←Older revision		Revision as of 07:16, 15 April 2020
Line 3:		Line 3:
	<StructureSection load='6s4c' size='340' side='right'caption='[[6s4c]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6s4c' size='340' side='right'caption='[[6s4c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6s4c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S4C OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6S4C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6s4c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S4C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6S4C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6s4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s4c OCA], [http://pdbe.org/6s4c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s4c RCSB], [http://www.ebi.ac.uk/pdbsum/6s4c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s4c ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Col7a1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6s4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s4c OCA], [http://pdbe.org/6s4c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s4c RCSB], [http://www.ebi.ac.uk/pdbsum/6s4c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s4c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Baumann, U]]		[[Category: Baumann, U]]
	[[Category: Flachsenberg, F]]		[[Category: Flachsenberg, F]]

OCA at 06:33, 19 February 2020

OCA — Wed, 19 Feb 2020 06:33:07 GMT

←Older revision		Revision as of 06:33, 19 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6s4c is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal Structure of the vWFA2 subdomain of type VII collagen==
		+	<StructureSection load='6s4c' size='340' side='right'caption='[[6s4c]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6s4c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S4C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S4C FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s4c OCA], [http://pdbe.org/6s4c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s4c RCSB], [http://www.ebi.ac.uk/pdbsum/6s4c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s4c ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CO7A1_MOUSE CO7A1_MOUSE]] Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.[UniProtKB:Q02388]<ref>PMID:10523500</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Type VII collagen is an extracellular matrix protein which is important for skin stability; however, detailed information at the molecular level is scarce. The second vWFA (von-Willebrand-factor type A) domain of type VII collagen mediates important interactions, and immunization of mice induces skin blistering in certain strains. To understand vWFA2 function and the pathophysiological mechanisms leading to skin blistering, we structurally characterized this domain by X-ray crystallography and NMR-spectroscopy. Cell adhesion assays identified two new interactions: one with beta1 integrin via its RGD motif and one with laminin-332. The latter interaction was confirmed by surface plasmon resonance with a KD of about 1 mM. These data show that vWFA2 has additional functions in the extracellular matrix besides interacting with type I collagen.

-	~~Authors~~:	+	Structural and biophysical characterization of the type VII collagen vWFA2 subdomain leads to identification of two binding sites.,Gebauer JM, Flachsenberg F, Windler C, Richer B, Baumann U, Seeger K FEBS Open Bio. 2020 Feb 7. doi: 10.1002/2211-5463.12807. PMID:32031736<ref>PMID:32031736</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6s4c" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Baumann, U]]
		+	[[Category: Flachsenberg, F]]
		+	[[Category: Gebauer, J M]]
		+	[[Category: Seeger, K]]
		+	[[Category: Collagen vii]]
		+	[[Category: Structural protein]]
		+	[[Category: Vwa]]
		+	[[Category: Vwfa]]

OCA: Protected "6s4c" [edit=sysop:move=sysop]

OCA — Wed, 03 Jul 2019 04:35:22 GMT

Protected "6s4c" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:35, 3 July 2019

OCA: New page: '''Unreleased structure''' The entry 6s4c is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Jul 2019 04:35:21 GMT

New page: '''Unreleased structure''' The entry 6s4c is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6s4c is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]