6s5t - Revision history

OCA at 10:14, 22 May 2024

OCA — Wed, 22 May 2024 10:14:13 GMT

←Older revision		Revision as of 10:14, 22 May 2024
Line 3:		Line 3:
	<SX load='6s5t' size='340' side='right' viewer='molstar' caption='[[6s5t]], [[Resolution\|resolution]] 4.15Å' scene=''>		<SX load='6s5t' size='340' side='right' viewer='molstar' caption='[[6s5t]], [[Resolution\|resolution]] 4.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6s5t]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_33152 Atcc 33152~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S5T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6S5T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6s5t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S5T FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.15Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~lpg2155 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=446 ATCC 33152]), CALM2, CAM2, CAMB ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6s5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s5t OCA], [~~http~~://pdbe.org/6s5t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6s5t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6s5t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6s5t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s5t OCA], [https://pdbe.org/6s5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s5t RCSB], [https://www.ebi.ac.uk/pdbsum/6s5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s5t ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/CALM2_HUMAN CALM2_HUMAN]] Catecholaminergic polymorphic ventricular tachycardia;Brugada syndrome;Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM2 are the cause of LQT15.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~CALM2_HUMAN CALM2_HUMAN~~]~~] Calmodulin~~ mediates the ~~control~~ of ~~a large number~~ of ~~enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among~~ the ~~enzymes to be stimulated by the calmodulin~~-~~calcium complex are a number of protein kinases and phosphatases~~. ~~Together with CCP110 and centrin~~, ~~is involved in a genetic pathway that regulates the centrosome cycle~~ and ~~progression through cytokinesis~~ (PubMed:~~16760425~~). ~~Mediates calcium-dependent inactivation of CACNA1C~~ (PubMed:~~26969752~~). ~~Positively regulates calcium~~-~~activated potassium channel~~ activity ~~of KCNN2~~ (PubMed:~~27165696~~).<ref>PMID:~~16760425~~</ref> <ref>PMID:~~26969752~~</ref> <ref>PMID:~~27165696~~</ref>	+	[https://www.uniprot.org/uniprot/SIDJ_LEGPH SIDJ_LEGPH] Glutamylase that mediates the covalent attachment of glutamate moieties to SdeA on one of the catalytic residues that is required for its mono-ADP-ribosyltransferase activity (PubMed:31330532, PubMed:31330531). In turn, inhibits SdeA ubiquitinating activity. Glutamylates also related SdeB, SdeC and SidE (PubMed:31330531, PubMed:31123136). Glutamylase activity only occurs in the host since it requires host calmodulin (PubMed:28497808, PubMed:31330532, PubMed:31330531, PubMed:31123136). May also reverse the SdeA-mediated substrate ubiquitination by cleaving the phosphodiester bond that links phosphoribosylated ubiquitin to protein substrates via its deubiquitinase activity (PubMed:28497808).<ref>PMID:28497808</ref> <ref>PMID:31123136</ref> <ref>PMID:31330531</ref> <ref>PMID:31330532</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6s5t" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6s5t" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Calmodulin 3D structures\|Calmodulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Atcc 33152]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Adams, M~~]]	+	[[Category: Legionella pneumophila]]
-	[[Category: ~~Bhogaraju, S]]~~	+	[[Category: Adams M]]
-	~~[[Category: Galej, W P]]~~	+	[[Category: Bhogaraju S]]
-	~~[[Category: Pfleiderer, M~~ M]]	+	[[Category: Galej WP]]
-	[[Category: ~~Bacterial glutamylase~~]]	+	[[Category: Pfleiderer MM]]
-	[[Category: ~~Calmodulin-dependent~~]]	+
-	[[Category: ~~Legionella]]~~	+
-	~~[[Category: Pseudo kinase]]~~	+
-	~~[[Category: Sdea]]~~	+
-	~~[[Category: Serine ubiquitination]]~~	+
-	~~[[Category: Sidj]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:01, 11 April 2020

OCA — Sat, 11 Apr 2020 06:01:06 GMT

←Older revision		Revision as of 06:01, 11 April 2020
Line 3:		Line 3:
	<SX load='6s5t' size='340' side='right' viewer='molstar' caption='[[6s5t]], [[Resolution\|resolution]] 4.15Å' scene=''>		<SX load='6s5t' size='340' side='right' viewer='molstar' caption='[[6s5t]], [[Resolution\|resolution]] 4.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6s5t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S5T OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6S5T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6s5t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S5T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6S5T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpg2155 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152]), CALM2, CAM2, CAMB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpg2155 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152]), CALM2, CAM2, CAMB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6s5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s5t OCA], [http://pdbe.org/6s5t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s5t RCSB], [http://www.ebi.ac.uk/pdbsum/6s5t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s5t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6s5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s5t OCA], [http://pdbe.org/6s5t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s5t RCSB], [http://www.ebi.ac.uk/pdbsum/6s5t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s5t ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 00:40, 7 March 2020

OCA — Sat, 07 Mar 2020 00:40:11 GMT

←Older revision		Revision as of 00:40, 7 March 2020
Line 1:		Line 1:

	==Legionella pneumophila SidJ-Human calmodulin complex==		==Legionella pneumophila SidJ-Human calmodulin complex==
-	<~~StructureSection~~ load='6s5t' size='340' side='right'caption='[[6s5t]], [[Resolution\|resolution]] 4.15Å' scene=''>	+	<SX load='6s5t' size='340' side='right' viewer='molstar' caption='[[6s5t]], [[Resolution\|resolution]] 4.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6s5t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S5T FirstGlance]. <br>		<table><tr><td colspan='2'>[[6s5t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S5T FirstGlance]. <br>
Line 24:		Line 24:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Atcc 33152]]		[[Category: Atcc 33152]]
	[[Category: Human]]		[[Category: Human]]

OCA at 07:07, 31 July 2019

OCA — Wed, 31 Jul 2019 07:07:51 GMT

←Older revision		Revision as of 07:07, 31 July 2019
Line 3:		Line 3:
	<StructureSection load='6s5t' size='340' side='right'caption='[[6s5t]], [[Resolution\|resolution]] 4.15Å' scene=''>		<StructureSection load='6s5t' size='340' side='right'caption='[[6s5t]], [[Resolution\|resolution]] 4.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6s5t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S5T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6s5t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S5T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpg2155 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152]), CALM2, CAM2, CAMB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s5t OCA], [http://pdbe.org/6s5t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s5t RCSB], [http://www.ebi.ac.uk/pdbsum/6s5t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s5t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s5t OCA], [http://pdbe.org/6s5t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s5t RCSB], [http://www.ebi.ac.uk/pdbsum/6s5t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s5t ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CALM2_HUMAN CALM2_HUMAN]] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>		[[http://www.uniprot.org/uniprot/CALM2_HUMAN CALM2_HUMAN]] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The family of bacterial SidE enzymes catalyses phosphoribosyl-linked (PR) serine ubiquitination and promotes infectivity of Legionella pneumophilia, a pathogenic bacterium causing Legionnaires' disease(1-3). SidEs share the genetic locus with the Legionella effector SidJ that spatiotemporally opposes their toxicity in yeast and mammalian cells, through an unknown mechanism(4-6). Deletion of SidJ leads to a significant defect in the growth of Legionella in both its natural host amoeba and in murine macrophages(4,5). Here, we demonstrate that SidJ is a glutamylase that modifies the catalytic glutamate in the mono-ADPribosyl transferase (mART) domain of SdeA thus blocking its ubiquitin (Ub) ligase activity. SidJ glutamylation activity requires interaction with calmodulin (CaM), a eukaryotic specific co-factor, and can be regulated by intracellular changes in Ca(2+) concentrations. The cryo-EM structure of SidJ/human apo-CaM complex revealed the architecture of this unique heterodimeric glutamylase. In infected cells, we show that SidJ mediates glutamylation of SidEs on the surface of Legionella-containing vacuoles (LCVs). Using quantitative proteomics, we also uncovered multiple host proteins as putative targets of SidJ-mediated glutamylation. Collectively, this study reveals the mechanism of SidE ligases inhibition by a SidJ/CaM glutamylase and opens new avenues for studying protein glutamylation, an understudied protein modification in higher eukaryotes.
		+
		+	Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin-catalysed glutamylation.,Bhogaraju S, Bonn F, Mukherjee R, Adams M, Pfleiderer MM, Galej WP, Matkovic V, Lopez-Mosqueda J, Kalayil S, Shin D, Dikic I Nature. 2019 Jul 22. pii: 10.1038/s41586-019-1440-8. doi:, 10.1038/s41586-019-1440-8. PMID:31330532<ref>PMID:31330532</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6s5t" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 33152]]
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Adams, M]]		[[Category: Adams, M]]

OCA at 06:30, 24 July 2019

OCA — Wed, 24 Jul 2019 06:30:30 GMT

←Older revision		Revision as of 06:30, 24 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6s5t is ~~ON HOLD until Paper Publication~~	+	==Legionella pneumophila SidJ-Human calmodulin complex==
-		+	<StructureSection load='6s5t' size='340' side='right'caption='[[6s5t]], [[Resolution\|resolution]] 4.15Å' scene=''>
-	~~Authors~~: ~~Bhogaraju~~, S., ~~Galej~~, W.P., ~~Pfleiderer, M~~.M., ~~Adams, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6s5t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S5T FirstGlance]. <br>
-	~~Description~~: ~~Legionella pneumophila SidJ~~-~~Human~~ calmodulin complex	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s5t OCA], [http://pdbe.org/6s5t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s5t RCSB], [http://www.ebi.ac.uk/pdbsum/6s5t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s5t ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CALM2_HUMAN CALM2_HUMAN]] Catecholaminergic polymorphic ventricular tachycardia;Brugada syndrome;Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM2 are the cause of LQT15.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CALM2_HUMAN CALM2_HUMAN]] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Adams, M]]		[[Category: Adams, M]]
-	[[Category: Pfleiderer, M.M]]
-	[[Category: Galej, W.P]]
	[[Category: Bhogaraju, S]]		[[Category: Bhogaraju, S]]
		+	[[Category: Galej, W P]]
		+	[[Category: Pfleiderer, M M]]
		+	[[Category: Bacterial glutamylase]]
		+	[[Category: Calmodulin-dependent]]
		+	[[Category: Legionella]]
		+	[[Category: Pseudo kinase]]
		+	[[Category: Sdea]]
		+	[[Category: Serine ubiquitination]]
		+	[[Category: Sidj]]
		+	[[Category: Transferase]]

OCA at 09:14, 17 July 2019

OCA — Wed, 17 Jul 2019 09:14:27 GMT

←Older revision		Revision as of 09:14, 17 July 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6s5t is ON HOLD	+	The entry 6s5t is ON HOLD until Paper Publication

-	Authors: Bhogaraju, S., Galej, W.P., Pfleiderer, M., Adams, M.	+	Authors: Bhogaraju, S., Galej, W.P., Pfleiderer, M.M., Adams, M.

	Description: Legionella pneumophila SidJ-Human calmodulin complex		Description: Legionella pneumophila SidJ-Human calmodulin complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Adams, M]]		[[Category: Adams, M]]
-	[[Category: Pfleiderer, M]]	+	[[Category: Pfleiderer, M.M]]
	[[Category: Galej, W.P]]		[[Category: Galej, W.P]]
	[[Category: Bhogaraju, S]]		[[Category: Bhogaraju, S]]

OCA: Protected "6s5t" [edit=sysop:move=sysop]

OCA — Wed, 10 Jul 2019 04:26:32 GMT

Protected "6s5t" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:26, 10 July 2019

OCA: New page: '''Unreleased structure''' The entry 6s5t is ON HOLD Authors: Bhogaraju, S., Galej, W.P., Pfleiderer, M., Adams, M. Description: Legionella pneumophila SidJ-Human calmodulin complex [[...

OCA — Wed, 10 Jul 2019 04:26:31 GMT

New page: '''Unreleased structure''' The entry 6s5t is ON HOLD Authors: Bhogaraju, S., Galej, W.P., Pfleiderer, M., Adams, M. Description: Legionella pneumophila SidJ-Human calmodulin complex [[...

New page

'''Unreleased structure'''

The entry 6s5t is ON HOLD

Authors: Bhogaraju, S., Galej, W.P., Pfleiderer, M., Adams, M.

Description: Legionella pneumophila SidJ-Human calmodulin complex
[[Category: Unreleased Structures]]
[[Category: Adams, M]]
[[Category: Pfleiderer, M]]
[[Category: Galej, W.P]]
[[Category: Bhogaraju, S]]