6s8j - Revision history

OCA at 06:04, 11 April 2020

OCA — Sat, 11 Apr 2020 06:04:10 GMT

←Older revision		Revision as of 06:04, 11 April 2020
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	<SX load='6s8j' size='340' side='right' viewer='molstar' caption='[[6s8j]], [[Resolution\|resolution]] 2.91Å' scene=''>		<SX load='6s8j' size='340' side='right' viewer='molstar' caption='[[6s8j]], [[Resolution\|resolution]] 2.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6s8j]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebov Ebov] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8J OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6S8J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6s8j]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebov Ebov] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8J OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6S8J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP, DF49_53415gpGP, DF49_53416gpGP, DF49_53417gpGP, DF49_53418gpGP, DF49_53419gpGP, DF49_53420gpGP, DF49_53421gpGP, DF49_53422gpGP, DF49_53423gpGP, DF49_53424gpGP, DF49_53425gpGP, DF49_53426gpGP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1570291 EBOV])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP, DF49_53415gpGP, DF49_53416gpGP, DF49_53417gpGP, DF49_53418gpGP, DF49_53419gpGP, DF49_53420gpGP, DF49_53421gpGP, DF49_53422gpGP, DF49_53423gpGP, DF49_53424gpGP, DF49_53425gpGP, DF49_53426gpGP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1570291 EBOV])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6s8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8j OCA], [http://pdbe.org/6s8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s8j RCSB], [http://www.ebi.ac.uk/pdbsum/6s8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6s8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8j OCA], [http://pdbe.org/6s8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s8j RCSB], [http://www.ebi.ac.uk/pdbsum/6s8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8j ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:43, 7 March 2020

OCA — Sat, 07 Mar 2020 00:43:38 GMT

←Older revision		Revision as of 00:43, 7 March 2020
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	==Structure of ZEBOV GP in complex with 5T0180 antibody==		==Structure of ZEBOV GP in complex with 5T0180 antibody==
-	<~~StructureSection~~ load='6s8j' size='340' side='right'caption='[[6s8j]], [[Resolution\|resolution]] 2.91Å' scene=''>	+	<SX load='6s8j' size='340' side='right' viewer='molstar' caption='[[6s8j]], [[Resolution\|resolution]] 2.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6s8j]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebov Ebov] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S8J FirstGlance]. <br>		<table><tr><td colspan='2'>[[6s8j]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebov Ebov] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S8J FirstGlance]. <br>
Line 20:		Line 20:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Ebov]]		[[Category: Ebov]]
	[[Category: Human]]		[[Category: Human]]

OCA at 10:30, 26 February 2020

OCA — Wed, 26 Feb 2020 10:30:51 GMT

←Older revision		Revision as of 10:30, 26 February 2020
Line 3:		Line 3:
	<StructureSection load='6s8j' size='340' side='right'caption='[[6s8j]], [[Resolution\|resolution]] 2.91Å' scene=''>		<StructureSection load='6s8j' size='340' side='right'caption='[[6s8j]], [[Resolution\|resolution]] 2.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6s8j]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S8J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6s8j]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebov Ebov] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S8J FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP, DF49_53415gpGP, DF49_53416gpGP, DF49_53417gpGP, DF49_53418gpGP, DF49_53419gpGP, DF49_53420gpGP, DF49_53421gpGP, DF49_53422gpGP, DF49_53423gpGP, DF49_53424gpGP, DF49_53425gpGP, DF49_53426gpGP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1570291 EBOV])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8j OCA], [http://pdbe.org/6s8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s8j RCSB], [http://www.ebi.ac.uk/pdbsum/6s8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8j OCA], [http://pdbe.org/6s8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s8j RCSB], [http://www.ebi.ac.uk/pdbsum/6s8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8j ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ebola virus disease is a severe health problem in Africa. Vaccines that display the Zaire ebolavirus glycoprotein spike complex are a prime component for the effort to combat it. The VH3-15/Vlambda1-40-based class of antibodies was recently discovered to be a common response in individuals who received the Ebola virus vaccines. These antibodies display attractive properties, and thus likely contribute to the efficacy of the vaccines. Here, we use cryo-EM to elucidate how three VH3-15/Vlambda1-40 antibodies from different individuals target the virus and found a convergent mechanism against a partially conserved site on the spike complex. Our study rationalizes the selection of the VH3-15/Vlambda1-40 germline genes for specifically targeting this site and highlights Ebolavirus species-specific sequence divergences that may restrict breadth of VH3-15/Vlambda1-40-based humoral response. The results from this study could help develop improved immunization schemes and further enable the design of immunogens that would be efficacious against a broader set of Ebolavirus species.
		+
		+	Structural Basis for a Convergent Immune Response against Ebola Virus.,Cohen-Dvashi H, Zehner M, Ehrhardt S, Katz M, Elad N, Klein F, Diskin R Cell Host Microbe. 2020 Feb 6. pii: S1931-3128(20)30046-9. doi:, 10.1016/j.chom.2020.01.007. PMID:32059794<ref>PMID:32059794</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6s8j" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ebov]]
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cohen-Dvashi, H]]		[[Category: Cohen-Dvashi, H]]

OCA at 04:23, 13 February 2020

OCA — Thu, 13 Feb 2020 04:23:59 GMT

←Older revision		Revision as of 04:23, 13 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6s8j ~~is ON HOLD~~	+	==Structure of ZEBOV GP in complex with 5T0180 antibody==
-		+	<StructureSection load='6s8j' size='340' side='right'caption='[[6s8j]], [[Resolution\|resolution]] 2.91Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6s8j]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S8J FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8j OCA], [http://pdbe.org/6s8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s8j RCSB], [http://www.ebi.ac.uk/pdbsum/6s8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8j ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cohen-Dvashi, H]]
		+	[[Category: Diskin, R]]
		+	[[Category: Antibody]]
		+	[[Category: Ebola]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Viral protein]]

OCA: Protected "6s8j" [edit=sysop:move=sysop]

OCA — Wed, 17 Jul 2019 09:17:39 GMT

Protected "6s8j" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:17, 17 July 2019

OCA: New page: '''Unreleased structure''' The entry 6s8j is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 17 Jul 2019 09:17:38 GMT

New page: '''Unreleased structure''' The entry 6s8j is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6s8j is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]