6sbj - Revision history

OCA at 12:38, 24 January 2024

OCA — Wed, 24 Jan 2024 12:38:55 GMT

←Older revision		Revision as of 12:38, 24 January 2024
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	<StructureSection load='6sbj' size='340' side='right'caption='[[6sbj]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='6sbj' size='340' side='right'caption='[[6sbj]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sbj]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SBJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6SBJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sbj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SBJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CL:CHLORIDE+ION'>CL</scene~~>, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.22Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Fahd1, MNCb-4134 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6sbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sbj OCA], [~~http~~://pdbe.org/6sbj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6sbj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6sbj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6sbj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sbj OCA], [https://pdbe.org/6sbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sbj RCSB], [https://www.ebi.ac.uk/pdbsum/6sbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sbj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FAHD1_MOUSE FAHD1_MOUSE]] Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (By similarity). Also has oxaloacetate decarboxylase activity (PubMed:25575590).[UniProtKB:Q6P587]<ref>PMID:25575590</ref>	+	[https://www.uniprot.org/uniprot/FAHD1_MOUSE FAHD1_MOUSE] Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (By similarity). Also has oxaloacetate decarboxylase activity (PubMed:25575590).[UniProtKB:Q6P587]<ref>PMID:25575590</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Naschberger, A]]	+	[[Category: Naschberger A]]
-	[[Category: Rupp, B]]	+	[[Category: Rupp B]]
-	[[Category: Weiss~~, A K.H]]~~	+	[[Category: Weiss AKH]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 08:03, 11 March 2020

OCA — Wed, 11 Mar 2020 08:03:33 GMT

←Older revision		Revision as of 08:03, 11 March 2020
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	<StructureSection load='6sbj' size='340' side='right'caption='[[6sbj]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='6sbj' size='340' side='right'caption='[[6sbj]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sbj]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SBJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sbj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SBJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Fahd1, MNCb-4134 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sbj OCA], [http://pdbe.org/6sbj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sbj RCSB], [http://www.ebi.ac.uk/pdbsum/6sbj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sbj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sbj OCA], [http://pdbe.org/6sbj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sbj RCSB], [http://www.ebi.ac.uk/pdbsum/6sbj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sbj ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Naschberger, A]]		[[Category: Naschberger, A]]
	[[Category: Rupp, B]]		[[Category: Rupp, B]]
	[[Category: Weiss, A K.H]]		[[Category: Weiss, A K.H]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 09:23, 26 February 2020

OCA — Wed, 26 Feb 2020 09:23:21 GMT

←Older revision		Revision as of 09:23, 26 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6sbj is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==X-ray structure of mus musculus Fumarylacetoacetate hydrolase domain containing protein 1 (FAHD1) apo-form uuncomplexed==
		+	<StructureSection load='6sbj' size='340' side='right'caption='[[6sbj]], [[Resolution\|resolution]] 2.22Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6sbj]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SBJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sbj OCA], [http://pdbe.org/6sbj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sbj RCSB], [http://www.ebi.ac.uk/pdbsum/6sbj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sbj ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FAHD1_MOUSE FAHD1_MOUSE]] Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (By similarity). Also has oxaloacetate decarboxylase activity (PubMed:25575590).[UniProtKB:Q6P587]<ref>PMID:25575590</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	FAH domain containing protein 1 (FAHD1) is a mammalian mitochondrial protein, displaying bifunctionality as acylpyruvate hydrolase (ApH) and oxaloacetate decarboxylase (ODx) activity. We report the crystal structure of mouse FAHD1 and structural mapping of the active site of mouse FAHD1. Despite high structural similarity with human FAHD1, a rabbit monoclonal antibody could be produced that is able to recognize mouse FAHD1, but not the human form, whereas a polyclonal antibody recognized both proteins. Epitope mapping in combination with our deposited crystal structures revealed that the epitope overlaps with a reported SIRT3 deacetylation site in mouse FAHD1.

-	~~Authors~~:	+	Structural and Functional Comparison of Fumarylacetoacetate Domain Containing Protein 1 (FAHD1) in Human and Mouse.,Weiss AKH, Naschberger A, Cappuccio E, Metzger C, Mottes L, Holzknecht M, von Velsen J, Bowler MW, Rupp B, Jansen-Durr P Biosci Rep. 2020 Feb 18. pii: 222164. doi: 10.1042/BSR20194431. PMID:32068790<ref>PMID:32068790</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6sbj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Naschberger, A]]
		+	[[Category: Rupp, B]]
		+	[[Category: Weiss, A K.H]]
		+	[[Category: Hydrolase]]

OCA: Protected "6sbj" [edit=sysop:move=sysop]

OCA — Wed, 31 Jul 2019 04:55:11 GMT

Protected "6sbj" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:55, 31 July 2019

OCA: New page: '''Unreleased structure''' The entry 6sbj is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 31 Jul 2019 04:55:10 GMT

New page: '''Unreleased structure''' The entry 6sbj is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6sbj is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]