6sbq - Revision history

OCA at 12:39, 24 January 2024

OCA — Wed, 24 Jan 2024 12:39:01 GMT

←Older revision		Revision as of 12:39, 24 January 2024
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	<StructureSection load='6sbq' size='340' side='right'caption='[[6sbq]], [[Resolution\|resolution]] 1.33Å' scene=''>		<StructureSection load='6sbq' size='340' side='right'caption='[[6sbq]], [[Resolution\|resolution]] 1.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sbq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SBQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6SBQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sbq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SBQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7ML:[(7~{S})-6,6-BIS(OXIDANYL)-4-PHENYL-5,7,8,9-TETRAHYDROBENZO[7]ANNULEN-7-YL]AZANIUM'>7ML</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.33Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane_alanyl_aminopeptidase Membrane alanyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.2 3.4.11.2] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7ML:[(7~{S})-6,6-BIS(OXIDANYL)-4-PHENYL-5,7,8,9-TETRAHYDROBENZO[7]ANNULEN-7-YL]AZANIUM'>7ML</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6sbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sbq OCA], [~~http~~://pdbe.org/6sbq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6sbq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6sbq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6sbq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sbq OCA], [https://pdbe.org/6sbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sbq RCSB], [https://www.ebi.ac.uk/pdbsum/6sbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sbq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6sbq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6sbq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminopeptidase 3D structures\|Aminopeptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Membrane alanyl aminopeptidase~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: Alavi, S]]	+	[[Category: Alavi S]]
-	[[Category: Albrecht, S]]	+	[[Category: Albrecht S]]
-	[[Category: Cavarelli, J]]	+	[[Category: Cavarelli J]]
-	[[Category: Florent, I]]	+	[[Category: Florent I]]
-	[[Category: McEwen~~, A G~~]]	+	[[Category: McEwen AG]]
-	[[Category: Mouray, E]]	+	[[Category: Mouray E]]
-	[[Category: Poussin-Courmontagne, P]]	+	[[Category: Poussin-Courmontagne P]]
-	[[Category: Salomon, E]]	+	[[Category: Salomon E]]
-	[[Category: Schmitt, M]]	+	[[Category: Schmitt M]]
-	[[Category: Tarnus, C]]	+	[[Category: Tarnus C]]
-	[[Category: Torchy, M]]	+	[[Category: Torchy M]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: M1 aminopeptidase~~]]	+

OCA at 10:18, 27 March 2020

OCA — Fri, 27 Mar 2020 10:18:16 GMT

←Older revision		Revision as of 10:18, 27 March 2020
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-	'''Unreleased structure'''

-	The ~~entry~~ 6sbq is ~~ON HOLD~~	+	==The crystal structure of PfA-M1 in complex with 7-amino-4-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one==
		+	<StructureSection load='6sbq' size='340' side='right'caption='[[6sbq]], [[Resolution\|resolution]] 1.33Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6sbq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SBQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7ML:[(7~{S})-6,6-BIS(OXIDANYL)-4-PHENYL-5,7,8,9-TETRAHYDROBENZO[7]ANNULEN-7-YL]AZANIUM'>7ML</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane_alanyl_aminopeptidase Membrane alanyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.2 3.4.11.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sbq OCA], [http://pdbe.org/6sbq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sbq RCSB], [http://www.ebi.ac.uk/pdbsum/6sbq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sbq ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aminobenzosuberone-based PfA-M1 inhibitors were explored as novel antimalarial agents against two different Plasmodium falciparum strains. The 4-phenyl derivative 7c exhibited the most encouraging growth inhibitory activity with IC50 values of 6.5-11.2 microM. X-ray crystal structures and early assessment of DMPK/ADME-Tox parameters allowed us to initiate structure-based drug design approach and understand the liabilities (such as potential metabolic and aqueous solubility issues) as well as identify the opportunities for improvement of this aminobenzosuberone series. It also suggested that compound 7c should be regarded as an attractive chemical tool to investigate the different biological roles of this multifunctional PfA-M1 protein.

-	~~Authors~~:	+	Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation.,Salomon E, Schmitt M, Mouray E, McEwen AG, Bounaadja L, Torchy M, Poussin-Courmontagne P, Alavi S, Tarnus C, Cavarelli J, Florent I, Albrecht S Bioorg Chem. 2020 Mar 11;98:103750. doi: 10.1016/j.bioorg.2020.103750. PMID:32182520<ref>PMID:32182520</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6sbq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Membrane alanyl aminopeptidase]]
		+	[[Category: Alavi, S]]
		+	[[Category: Albrecht, S]]
		+	[[Category: Cavarelli, J]]
		+	[[Category: Florent, I]]
		+	[[Category: McEwen, A G]]
		+	[[Category: Mouray, E]]
		+	[[Category: Poussin-Courmontagne, P]]
		+	[[Category: Salomon, E]]
		+	[[Category: Schmitt, M]]
		+	[[Category: Tarnus, C]]
		+	[[Category: Torchy, M]]
		+	[[Category: Hydrolase]]
		+	[[Category: M1 aminopeptidase]]

OCA: Protected "6sbq" [edit=sysop:move=sysop]

OCA — Wed, 31 Jul 2019 04:55:35 GMT

Protected "6sbq" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:55, 31 July 2019

OCA: New page: '''Unreleased structure''' The entry 6sbq is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 31 Jul 2019 04:55:34 GMT

New page: '''Unreleased structure''' The entry 6sbq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6sbq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]