6sgy - Revision history

OCA at 06:09, 11 April 2020

OCA — Sat, 11 Apr 2020 06:09:52 GMT

←Older revision		Revision as of 06:09, 11 April 2020
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	<SX load='6sgy' size='340' side='right' viewer='molstar' caption='[[6sgy]], [[Resolution\|resolution]] 4.60Å' scene=''>		<SX load='6sgy' size='340' side='right' viewer='molstar' caption='[[6sgy]], [[Resolution\|resolution]] 4.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sgy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SGY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6SGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sgy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SGY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SGY FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eccB3, MSMEG_0616, MSMEI_0600 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eccB3, MSMEG_0616, MSMEI_0600 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6sgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sgy OCA], [http://pdbe.org/6sgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sgy RCSB], [http://www.ebi.ac.uk/pdbsum/6sgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sgy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sgy OCA], [http://pdbe.org/6sgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sgy RCSB], [http://www.ebi.ac.uk/pdbsum/6sgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sgy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 00:50, 7 March 2020

OCA — Sat, 07 Mar 2020 00:50:48 GMT

←Older revision		Revision as of 00:50, 7 March 2020
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	==Structure of EccB3 dimer from the ESX-3 core complex==		==Structure of EccB3 dimer from the ESX-3 core complex==
-	<~~StructureSection~~ load='6sgy' size='340' side='right'caption='[[6sgy]], [[Resolution\|resolution]] 4.60Å' scene=''>	+	<SX load='6sgy' size='340' side='right' viewer='molstar' caption='[[6sgy]], [[Resolution\|resolution]] 4.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6sgy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SGY FirstGlance]. <br>		<table><tr><td colspan='2'>[[6sgy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SGY FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mycs2]]		[[Category: Mycs2]]

OCA at 08:14, 23 October 2019

OCA — Wed, 23 Oct 2019 08:14:38 GMT

←Older revision		Revision as of 08:14, 23 October 2019
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	<StructureSection load='6sgy' size='340' side='right'caption='[[6sgy]], [[Resolution\|resolution]] 4.60Å' scene=''>		<StructureSection load='6sgy' size='340' side='right'caption='[[6sgy]], [[Resolution\|resolution]] 4.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sgy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sgy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SGY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sgy OCA], [http://pdbe.org/6sgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sgy RCSB], [http://www.ebi.ac.uk/pdbsum/6sgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sgy ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eccB3, MSMEG_0616, MSMEI_0600 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sgy OCA], [http://pdbe.org/6sgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sgy RCSB], [http://www.ebi.ac.uk/pdbsum/6sgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sgy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ECCB3_MYCS2 ECCB3_MYCS2]] An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is required for siderophore-mediated iron acquisition and for the secretion of EsxH and EsxG.[UniProtKB:P9WNR7]<ref>PMID:19846780</ref> <ref>PMID:24803520</ref>		[[http://www.uniprot.org/uniprot/ECCB3_MYCS2 ECCB3_MYCS2]] An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is required for siderophore-mediated iron acquisition and for the secretion of EsxH and EsxG.[UniProtKB:P9WNR7]<ref>PMID:19846780</ref> <ref>PMID:24803520</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Host infection by pathogenic mycobacteria such as Mycobacterium tuberculosis is facilitated by virulence factors secreted by type VII secretion systems(1). Here we report the cryo-electron microscopy structure of a membrane-embedded core complex of the ESX-3/type VII secretion system from Mycobacterium smegmatis at 3.7 A resolution. The core of the ESX-3 secretion machine consists of four protein components, EccB3:EccC3:EccD3:EccE3 in a 1:1:2:1 stoichiometry, building two identical protomers. The EccC3 coupling protein comprises a flexible array of four ATPase domains, which are linked to the membrane through a stalk domain. The 'domain of unknown function' (DUF) adjacent to the stalk is identified as an ATPase domain essential for secretion. EccB3 is predominantly periplasmatic but a small segment crosses the membrane and contacts the stalk domain, suggesting that conformational changes in the stalk domain triggered by substrate binding at the distal end of EccC3 and subsequent ATP hydrolysis in the DUF could be coupled to substrate secretion to the periplasm. Our results reveal that the architecture of type VII secretion systems differs markedly from other known secretion machines(2).
		+
		+	Architecture of the mycobacterial type VII secretion system.,Famelis N, Rivera-Calzada A, Degliesposti G, Wingender M, Mietrach N, Skehel JM, Fernandez-Leiro R, Bottcher B, Schlosser A, Llorca O, Geibel S Nature. 2019 Oct 9. pii: 10.1038/s41586-019-1633-1. doi:, 10.1038/s41586-019-1633-1. PMID:31597161<ref>PMID:31597161</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6sgy" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mycs2]]
	[[Category: Famelis, N]]		[[Category: Famelis, N]]
	[[Category: Geibel, S]]		[[Category: Geibel, S]]

OCA at 05:27, 10 October 2019

OCA — Thu, 10 Oct 2019 05:27:27 GMT

←Older revision		Revision as of 05:27, 10 October 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6sgy ~~is ON HOLD until Paper Publication~~	+	==Structure of EccB3 dimer from the ESX-3 core complex==
-		+	<StructureSection load='6sgy' size='340' side='right'caption='[[6sgy]], [[Resolution\|resolution]] 4.60Å' scene=''>
-	~~Authors~~: ~~Famelis, N~~., ~~Rivera~~-~~Calzada~~, A., ~~Llorca~~, O., ~~Geibel, S~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6sgy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SGY FirstGlance]. <br>
-	~~Description~~: ~~Structure~~ of ~~EccB3 dimer from~~ the ESX-3 ~~core complex~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sgy OCA], [http://pdbe.org/6sgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sgy RCSB], [http://www.ebi.ac.uk/pdbsum/6sgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sgy ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ECCB3_MYCS2 ECCB3_MYCS2]] An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is required for siderophore-mediated iron acquisition and for the secretion of EsxH and EsxG.[UniProtKB:P9WNR7]<ref>PMID:19846780</ref> <ref>PMID:24803520</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Famelis, N]]		[[Category: Famelis, N]]
		+	[[Category: Geibel, S]]
		+	[[Category: Llorca, O]]
	[[Category: Rivera-Calzada, A]]		[[Category: Rivera-Calzada, A]]
-	[[Category: ~~Llorca, O~~]]	+	[[Category: Membrane protein]]
-	[[Category: ~~Geibel, S~~]]	+	[[Category: Type vii secretion system esx-3 secretion system t7ss esx-3 mycobacterium smegmati]]

OCA at 07:22, 2 October 2019

OCA — Wed, 02 Oct 2019 07:22:41 GMT

←Older revision		Revision as of 07:22, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6sgy is ON HOLD	+	The entry 6sgy is ON HOLD until Paper Publication

	Authors: Famelis, N., Rivera-Calzada, A., Llorca, O., Geibel, S.		Authors: Famelis, N., Rivera-Calzada, A., Llorca, O., Geibel, S.
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	Description: Structure of EccB3 dimer from the ESX-3 core complex		Description: Structure of EccB3 dimer from the ESX-3 core complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Llorca, O]]
	[[Category: Famelis, N]]		[[Category: Famelis, N]]
-	[[Category: Geibel, S]]
	[[Category: Rivera-Calzada, A]]		[[Category: Rivera-Calzada, A]]
		+	[[Category: Llorca, O]]
		+	[[Category: Geibel, S]]

OCA: Protected "6sgy" [edit=sysop:move=sysop]

OCA — Wed, 14 Aug 2019 15:12:54 GMT

Protected "6sgy" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:12, 14 August 2019

OCA: New page: '''Unreleased structure''' The entry 6sgy is ON HOLD Authors: Famelis, N., Rivera-Calzada, A., Llorca, O., Geibel, S. Description: Structure of EccB3 dimer from the ESX-3 core complex ...

OCA — Wed, 14 Aug 2019 15:12:52 GMT

New page: '''Unreleased structure''' The entry 6sgy is ON HOLD Authors: Famelis, N., Rivera-Calzada, A., Llorca, O., Geibel, S. Description: Structure of EccB3 dimer from the ESX-3 core complex ...

New page

'''Unreleased structure'''

The entry 6sgy is ON HOLD

Authors: Famelis, N., Rivera-Calzada, A., Llorca, O., Geibel, S.

Description: Structure of EccB3 dimer from the ESX-3 core complex
[[Category: Unreleased Structures]]
[[Category: Llorca, O]]
[[Category: Famelis, N]]
[[Category: Geibel, S]]
[[Category: Rivera-Calzada, A]]