6sja - Revision history

OCA at 12:42, 24 January 2024

OCA — Wed, 24 Jan 2024 12:42:43 GMT

←Older revision		Revision as of 12:42, 24 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6sja]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SJA FirstGlance]. <br>		<table><tr><td colspan='2'>[[6sja]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SJA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sja OCA], [https://pdbe.org/6sja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sja RCSB], [https://www.ebi.ac.uk/pdbsum/6sja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sja ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sja OCA], [https://pdbe.org/6sja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sja RCSB], [https://www.ebi.ac.uk/pdbsum/6sja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sja ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[[https://www.uniprot.org/uniprot/IRF3_HUMAN IRF3_HUMAN]] Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.	+	[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/IRF3_HUMAN IRF3_HUMAN] Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

	==See Also==		==See Also==

OCA at 05:20, 8 September 2022

OCA — Thu, 08 Sep 2022 05:20:15 GMT

←Older revision		Revision as of 05:20, 8 September 2022
Line 1:		Line 1:

-	====	+	==Structure of HPV16 E6 oncoprotein in complex with IRF3 LxxLL motif==
-	<StructureSection load='6sja' size='340' side='right'caption='[[6sja]]' scene=''>	+	<StructureSection load='6sja' size='340' side='right'caption='[[6sja]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sja]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SJA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sja OCA], [https://pdbe.org/6sja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sja RCSB], [https://www.ebi.ac.uk/pdbsum/6sja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sja ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sja OCA], [https://pdbe.org/6sja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sja RCSB], [https://www.ebi.ac.uk/pdbsum/6sja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sja ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[[https://www.uniprot.org/uniprot/IRF3_HUMAN IRF3_HUMAN]] Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
		+
		+	==See Also==
		+	*[[Maltose-binding protein 3D structures\|Maltose-binding protein 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Human papillomavirus type 16]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z-~~disk~~]]	+	[[Category: Bonhoure A]]
		+	[[Category: Cousido-Siah A]]
		+	[[Category: Mitschler A]]
		+	[[Category: Podjarny A]]
		+	[[Category: Suarez IP]]
		+	[[Category: Trave G]]

OCA at 07:55, 10 November 2021

OCA — Wed, 10 Nov 2021 07:55:24 GMT

←Older revision		Revision as of 07:55, 10 November 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6sja ~~is ON HOLD~~	+	====
-		+	<StructureSection load='6sja' size='340' side='right'caption='[[6sja]]' scene=''>
-	~~Authors~~: ~~Suarez, I~~.P.~~, Cousido~~-~~Siah, A~~.~~, Bonhoure, A~~.~~, Mitschler, A~~.~~, Podjarny, A., Trave, G~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Structure of HPV16 E6 oncoprotein in complex with IRF3 LxxLL motif~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sja OCA], [https://pdbe.org/6sja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sja RCSB], [https://www.ebi.ac.uk/pdbsum/6sja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sja ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Cousido~~-~~Siah, A~~]]	+	__TOC__
-	[~~[Category~~: ~~Mitschler, A]~~]	+	</StructureSection>
-	[~~[Category~~: ~~Suarez, I~~.P]]	+	[[Category: Large Structures]]
-	[~~[Category~~: ~~Trave~~, G]]	+	[[Category: Z-disk]]
-	[[Category: ~~Bonhoure, A~~]]	+
-	[[Category: ~~Podjarny, A~~]]	+

OCA: Protected "6sja" [edit=sysop:move=sysop]

OCA — Wed, 21 Aug 2019 04:19:00 GMT

Protected "6sja" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:19, 21 August 2019

OCA: New page: '''Unreleased structure''' The entry 6sja is ON HOLD Authors: Suarez, I.P., Cousido-Siah, A., Bonhoure, A., Mitschler, A., Podjarny, A., Trave, G. Description: Structure of HPV16 E6 on...

OCA — Wed, 21 Aug 2019 04:18:58 GMT

New page: '''Unreleased structure''' The entry 6sja is ON HOLD Authors: Suarez, I.P., Cousido-Siah, A., Bonhoure, A., Mitschler, A., Podjarny, A., Trave, G. Description: Structure of HPV16 E6 on...

New page

'''Unreleased structure'''

The entry 6sja is ON HOLD

Authors: Suarez, I.P., Cousido-Siah, A., Bonhoure, A., Mitschler, A., Podjarny, A., Trave, G.

Description: Structure of HPV16 E6 oncoprotein in complex with IRF3 LxxLL motif
[[Category: Unreleased Structures]]
[[Category: Cousido-Siah, A]]
[[Category: Mitschler, A]]
[[Category: Suarez, I.P]]
[[Category: Trave, G]]
[[Category: Bonhoure, A]]
[[Category: Podjarny, A]]