6slt - Revision history

OCA at 12:43, 24 January 2024

OCA — Wed, 24 Jan 2024 12:43:54 GMT

←Older revision		Revision as of 12:43, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6slt' size='340' side='right'caption='[[6slt]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='6slt' size='340' side='right'caption='[[6slt]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6slt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_23875 Atcc 23875~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SLT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6SLT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6slt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_albogriseolus Streptomyces albogriseolus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SLT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SLT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6h44\|6h44]], [[6h43\|6h43]], [[6ib5\|6ib5]], [[6sls\|6sls]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">thal, thdH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1887 ATCC 23875])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6slt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6slt OCA], [https://pdbe.org/6slt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6slt RCSB], [https://www.ebi.ac.uk/pdbsum/6slt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6slt ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6slt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6slt OCA], [~~http~~://pdbe.org/6slt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6slt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6slt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6slt ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A1E280_STRAO A1E280_STRAO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 23875]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Moritzer, A~~]]	+	[[Category: Streptomyces albogriseolus]]
-	[[Category: ~~Niemann, H H~~]]	+	[[Category: Moritzer A]]
-	[[Category: ~~Fad]]~~	+	[[Category: Niemann HH]]
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Thal]]~~	+
-	~~[[Category: Thdh]]~~	+
-	~~[[Category: Tryptophan]]~~	+
-	~~[[Category: Tryptophan halogenase~~]]	+

OCA at 09:44, 30 October 2019

OCA — Wed, 30 Oct 2019 09:44:13 GMT

←Older revision		Revision as of 09:44, 30 October 2019
Line 3:		Line 3:
	<StructureSection load='6slt' size='340' side='right'caption='[[6slt]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='6slt' size='340' side='right'caption='[[6slt]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6slt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SLT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SLT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6slt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_23875 Atcc 23875]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SLT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SLT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6h44\|6h44]], [[6h43\|6h43]], [[6ib5\|6ib5]], [[6sls\|6sls]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6h44\|6h44]], [[6h43\|6h43]], [[6ib5\|6ib5]], [[6sls\|6sls]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">thal, thdH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1887 ATCC 23875])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6slt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6slt OCA], [http://pdbe.org/6slt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6slt RCSB], [http://www.ebi.ac.uk/pdbsum/6slt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6slt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6slt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6slt OCA], [http://pdbe.org/6slt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6slt RCSB], [http://www.ebi.ac.uk/pdbsum/6slt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6slt ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 23875]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Moritzer, A]]		[[Category: Moritzer, A]]

OCA at 06:02, 16 October 2019

OCA — Wed, 16 Oct 2019 06:02:55 GMT

←Older revision		Revision as of 06:02, 16 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6slt is ~~ON HOLD until Paper~~ Publication	+	==Flavin-dependent tryptophan 6-halogenase Thal in complex with tryptophan and FAD==
		+	<StructureSection load='6slt' size='340' side='right'caption='[[6slt]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6slt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SLT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SLT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6h44\|6h44]], [[6h43\|6h43]], [[6ib5\|6ib5]], [[6sls\|6sls]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6slt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6slt OCA], [http://pdbe.org/6slt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6slt RCSB], [http://www.ebi.ac.uk/pdbsum/6slt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6slt ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Flavin-dependent halogenases require FADH2 , O2 and halide salts to halogenate their substrates. We describe crystal structures of the tryptophan 6-halogenase Thal in complex with FAD or with both tryptophan and FAD. If tryptophan and FAD were soaked simultaneously both ligands showed impaired binding and in some cases only the AMP or the adenosine moiety of FAD was resolved, suggesting that tryptophan binding mainly increases mobility of the FMN moiety. This confirms a negative cooperativity between substrate and cofactor binding previously described for other tryptophan halogenases. Binding of substrate to tryptophan halogenases reduces the affinity for the oxidized cofactor FAD presumably to facilitate regeneration of FADH2 by flavin reductases. This article is protected by copyright. All rights reserved.

-	~~Authors~~:	+	Binding of FAD and tryptophan to the tryptophan 6-halogenase Thal are negatively coupled.,Moritzer AC, Niemann HH Protein Sci. 2019 Oct 7. doi: 10.1002/pro.3739. PMID:31589794<ref>PMID:31589794</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6slt" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Moritzer, A]]
		+	[[Category: Niemann, H H]]
		+	[[Category: Fad]]
		+	[[Category: Flavoprotein]]
		+	[[Category: Thal]]
		+	[[Category: Thdh]]
		+	[[Category: Tryptophan]]
		+	[[Category: Tryptophan halogenase]]

OCA at 07:23, 2 October 2019

OCA — Wed, 02 Oct 2019 07:23:52 GMT

←Older revision		Revision as of 07:23, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6slt is ON HOLD	+	The entry 6slt is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6slt" [edit=sysop:move=sysop]

OCA — Wed, 28 Aug 2019 13:55:22 GMT

Protected "6slt" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:55, 28 August 2019

OCA: New page: '''Unreleased structure''' The entry 6slt is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Aug 2019 13:55:21 GMT

New page: '''Unreleased structure''' The entry 6slt is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6slt is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]