6sm4 - Revision history

OCA at 12:44, 24 January 2024

OCA — Wed, 24 Jan 2024 12:44:04 GMT

←Older revision		Revision as of 12:44, 24 January 2024
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	<StructureSection load='6sm4' size='340' side='right'caption='[[6sm4]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='6sm4' size='340' side='right'caption='[[6sm4]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sm4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_29999 Atcc 29999~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SM4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6SM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sm4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Photorhabdus_luminescens Photorhabdus luminescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SM4 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[2fad\|2fad]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">C6H68_21855 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=29488 ATCC 29999])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sm4 OCA], [https://pdbe.org/6sm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sm4 RCSB], [https://www.ebi.ac.uk/pdbsum/6sm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sm4 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6sm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sm4 OCA], [~~http~~://pdbe.org/6sm4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6sm4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6sm4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6sm4 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A2S8QL96_PHOLU A0A2S8QL96_PHOLU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 29999]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bode, H]]	+	[[Category: Photorhabdus luminescens]]
-	[[Category: Braeuer, A]]	+	[[Category: Bode H]]
-	[[Category: Grammbitter~~, G L.C~~]]	+	[[Category: Braeuer A]]
-	[[Category: Groll, M]]	+	[[Category: Grammbitter GLC]]
-	[[Category: Kaila~~, V R.I~~]]	+	[[Category: Groll M]]
-	[[Category: Ruehl, M]]	+	[[Category: Kaila VRI]]
-	[[Category: Schmalhofer, M]]	+	[[Category: Ruehl M]]
-	[[Category: Zhou, Q]]	+	[[Category: Schmalhofer M]]
-	~~[[Category: Anthraquinone]]~~	+	[[Category: Zhou Q]]
-	~~[[Category: Catalysis]]~~	+
-	~~[[Category: Chain elongation]]~~	+
-	~~[[Category: Minimal pks system]]~~	+
-	~~[[Category: Natural product biosynthesis]]~~	+
-	~~[[Category: Polyketide]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 05:51, 5 August 2020

OCA — Wed, 05 Aug 2020 05:51:29 GMT

←Older revision		Revision as of 05:51, 5 August 2020
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	==AntF (apo): type II PKS acyl-carrier protein==		==AntF (apo): type II PKS acyl-carrier protein==
-	<StructureSection load='6sm4' size='340' side='right'caption='[[6sm4]]' scene=''>	+	<StructureSection load='6sm4' size='340' side='right'caption='[[6sm4]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SM4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sm4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29999 Atcc 29999]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SM4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SM4 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sm4 OCA], [http://pdbe.org/6sm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sm4 RCSB], [http://www.ebi.ac.uk/pdbsum/6sm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sm4 ProSAT]</span></td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fad\|2fad]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C6H68_21855 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29488 ATCC 29999])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sm4 OCA], [http://pdbe.org/6sm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sm4 RCSB], [http://www.ebi.ac.uk/pdbsum/6sm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sm4 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Type II polyketide synthases (PKSs) are multi-enzyme complexes that produce secondary metabolites of medical relevance. Chemical backbones of such polyketides are produced by minimal PKS systems that consist of a malonyl transacylase, an acyl carrier protein and an alpha/beta heterodimeric ketosynthase. Here, we present X-ray structures of all ternary complexes that constitute the minimal PKS system for anthraquinone biosynthesis in Photorhabdus luminescens. In addition, we characterize this invariable core using molecular simulations, mutagenesis experiments and functional assays. We show that malonylation of the acyl carrier protein is accompanied by major structural rearrangements in the transacylase. Principles of an ongoing chain elongation are derived from the ternary complex with a hexaketide covalently linking the heterodimeric ketosynthase with the acyl carrier protein. Our results for the minimal PKS system provide mechanistic understanding of PKSs and a fundamental basis for engineering PKS pathways for future applications.
		+
		+	Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis.,Brauer A, Zhou Q, Grammbitter GLC, Schmalhofer M, Ruhl M, Kaila VRI, Bode HB, Groll M Nat Chem. 2020 Aug;12(8):755-763. doi: 10.1038/s41557-020-0491-7. Epub 2020 Jul, 6. PMID:32632186<ref>PMID:32632186</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6sm4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acyl carrier protein 3D structures\|Acyl carrier protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 29999]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bode H]]	+	[[Category: Bode, H]]
-	[[Category: Braeuer A]]	+	[[Category: Braeuer, A]]
-	[[Category: Grammbitter ~~GLC~~]]	+	[[Category: Grammbitter, G L.C]]
-	[[Category: Groll M]]	+	[[Category: Groll, M]]
-	[[Category: Kaila ~~VRI~~]]	+	[[Category: Kaila, V R.I]]
-	[[Category: Ruehl M]]	+	[[Category: Ruehl, M]]
-	[[Category: Schmalhofer M]]	+	[[Category: Schmalhofer, M]]
-	[[Category: Zhou Q]]	+	[[Category: Zhou, Q]]
		+	[[Category: Anthraquinone]]
		+	[[Category: Catalysis]]
		+	[[Category: Chain elongation]]
		+	[[Category: Minimal pks system]]
		+	[[Category: Natural product biosynthesis]]
		+	[[Category: Polyketide]]
		+	[[Category: Protein binding]]

OCA at 06:56, 27 May 2020

OCA — Wed, 27 May 2020 06:56:24 GMT

←Older revision		Revision as of 06:56, 27 May 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6sm4 is ~~ON HOLD until Paper Publication~~	+	==AntF (apo): type II PKS acyl-carrier protein==
-		+	<StructureSection load='6sm4' size='340' side='right'caption='[[6sm4]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SM4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SM4 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sm4 OCA], [http://pdbe.org/6sm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sm4 RCSB], [http://www.ebi.ac.uk/pdbsum/6sm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sm4 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bode H]]
		+	[[Category: Braeuer A]]
		+	[[Category: Grammbitter GLC]]
		+	[[Category: Groll M]]
		+	[[Category: Kaila VRI]]
		+	[[Category: Ruehl M]]
		+	[[Category: Schmalhofer M]]
		+	[[Category: Zhou Q]]

OCA: Protected "6sm4" [edit=sysop:move=sysop]

OCA — Wed, 28 Aug 2019 13:56:55 GMT

Protected "6sm4" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:56, 28 August 2019

OCA: New page: '''Unreleased structure''' The entry 6sm4 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Aug 2019 13:56:54 GMT

New page: '''Unreleased structure''' The entry 6sm4 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6sm4 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]