6smo - Revision history

OCA at 12:44, 24 January 2024

OCA — Wed, 24 Jan 2024 12:44:20 GMT

←Older revision		Revision as of 12:44, 24 January 2024
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	<StructureSection load='6smo' size='340' side='right'caption='[[6smo]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='6smo' size='340' side='right'caption='[[6smo]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6smo]] is a 7 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_29999 Atcc 29999~~] and [~~http~~://en.wikipedia.org/wiki/~~Pholl Pholl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SMO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6SMO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6smo]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Photorhabdus_laumondii_subsp._laumondii_TTO1 Photorhabdus laumondii subsp. laumondii TTO1] and [https://en.wikipedia.org/wiki/Photorhabdus_luminescens Photorhabdus luminescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SMO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LKZ:3,5,7,9,11-pentakis(oxidanylidene)dodecanal'>LKZ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6sm4\|6sm4]], [[1tqy\|1tqy]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LKZ:3,5,7,9,11-pentakis(oxidanylidene)dodecanal'>LKZ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C6H68_21855 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29488 ATCC 29999]), plu4191 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243265 PHOLL]), plu4190 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243265 PHOLL])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6smo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6smo OCA], [https://pdbe.org/6smo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6smo RCSB], [https://www.ebi.ac.uk/pdbsum/6smo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6smo ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6smo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6smo OCA], [~~http~~://pdbe.org/6smo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6smo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6smo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6smo ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7MZT5_PHOLL Q7MZT5_PHOLL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 29999]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pholl~~]]	+	[[Category: Photorhabdus laumondii subsp. laumondii TTO1]]
-	[[Category: Bode, H]]	+	[[Category: Photorhabdus luminescens]]
-	[[Category: Braeuer, A]]	+	[[Category: Bode H]]
-	[[Category: Grammbitter~~, G L.C~~]]	+	[[Category: Braeuer A]]
-	[[Category: Groll, M]]	+	[[Category: Grammbitter GLC]]
-	[[Category: Kaila~~, V R.I~~]]	+	[[Category: Groll M]]
-	[[Category: Ruehl, M]]	+	[[Category: Kaila VRI]]
-	[[Category: Schmalhofer, M]]	+	[[Category: Ruehl M]]
-	[[Category: Zhou, Q]]	+	[[Category: Schmalhofer M]]
-	~~[[Category: Anthraquinone]]~~	+	[[Category: Zhou Q]]
-	~~[[Category: Catalysis]]~~	+
-	~~[[Category: Chain elongation]]~~	+
-	~~[[Category: Minimal pks system]]~~	+
-	~~[[Category: Natural product biosynthesis]]~~	+
-	~~[[Category: Polyketide]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 05:52, 5 August 2020

OCA — Wed, 05 Aug 2020 05:52:14 GMT

←Older revision		Revision as of 05:52, 5 August 2020
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	==AntDE:AntF (apo): type II PKS acyl-carrier protein in complex with its ketosynthase bound to the hexaketide==		==AntDE:AntF (apo): type II PKS acyl-carrier protein in complex with its ketosynthase bound to the hexaketide==
-	<StructureSection load='6smo' size='340' side='right'caption='[[6smo]]' scene=''>	+	<StructureSection load='6smo' size='340' side='right'caption='[[6smo]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SMO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SMO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6smo]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29999 Atcc 29999] and [http://en.wikipedia.org/wiki/Pholl Pholl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SMO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SMO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6smo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6smo OCA], [http://pdbe.org/6smo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6smo RCSB], [http://www.ebi.ac.uk/pdbsum/6smo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6smo ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LKZ:3,5,7,9,11-pentakis(oxidanylidene)dodecanal'>LKZ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6sm4\|6sm4]], [[1tqy\|1tqy]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C6H68_21855 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29488 ATCC 29999]), plu4191 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243265 PHOLL]), plu4190 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243265 PHOLL])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6smo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6smo OCA], [http://pdbe.org/6smo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6smo RCSB], [http://www.ebi.ac.uk/pdbsum/6smo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6smo ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Type II polyketide synthases (PKSs) are multi-enzyme complexes that produce secondary metabolites of medical relevance. Chemical backbones of such polyketides are produced by minimal PKS systems that consist of a malonyl transacylase, an acyl carrier protein and an alpha/beta heterodimeric ketosynthase. Here, we present X-ray structures of all ternary complexes that constitute the minimal PKS system for anthraquinone biosynthesis in Photorhabdus luminescens. In addition, we characterize this invariable core using molecular simulations, mutagenesis experiments and functional assays. We show that malonylation of the acyl carrier protein is accompanied by major structural rearrangements in the transacylase. Principles of an ongoing chain elongation are derived from the ternary complex with a hexaketide covalently linking the heterodimeric ketosynthase with the acyl carrier protein. Our results for the minimal PKS system provide mechanistic understanding of PKSs and a fundamental basis for engineering PKS pathways for future applications.
		+
		+	Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis.,Brauer A, Zhou Q, Grammbitter GLC, Schmalhofer M, Ruhl M, Kaila VRI, Bode HB, Groll M Nat Chem. 2020 Aug;12(8):755-763. doi: 10.1038/s41557-020-0491-7. Epub 2020 Jul, 6. PMID:32632186<ref>PMID:32632186</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6smo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acyl carrier protein 3D structures\|Acyl carrier protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 29999]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bode H]]	+	[[Category: Pholl]]
-	[[Category: Braeuer A]]	+	[[Category: Bode, H]]
-	[[Category: Grammbitter ~~GLC~~]]	+	[[Category: Braeuer, A]]
-	[[Category: Groll M]]	+	[[Category: Grammbitter, G L.C]]
-	[[Category: Kaila ~~VRI~~]]	+	[[Category: Groll, M]]
-	[[Category: Ruehl M]]	+	[[Category: Kaila, V R.I]]
-	[[Category: Schmalhofer M]]	+	[[Category: Ruehl, M]]
-	[[Category: Zhou Q]]	+	[[Category: Schmalhofer, M]]
		+	[[Category: Zhou, Q]]
		+	[[Category: Anthraquinone]]
		+	[[Category: Catalysis]]
		+	[[Category: Chain elongation]]
		+	[[Category: Minimal pks system]]
		+	[[Category: Natural product biosynthesis]]
		+	[[Category: Polyketide]]
		+	[[Category: Protein binding]]

OCA at 06:56, 27 May 2020

OCA — Wed, 27 May 2020 06:56:52 GMT

←Older revision		Revision as of 06:56, 27 May 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6smo is ~~ON HOLD until Paper Publication~~	+	==AntDE:AntF (apo): type II PKS acyl-carrier protein in complex with its ketosynthase bound to the hexaketide==
-		+	<StructureSection load='6smo' size='340' side='right'caption='[[6smo]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SMO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SMO FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6smo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6smo OCA], [http://pdbe.org/6smo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6smo RCSB], [http://www.ebi.ac.uk/pdbsum/6smo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6smo ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bode H]]
		+	[[Category: Braeuer A]]
		+	[[Category: Grammbitter GLC]]
		+	[[Category: Groll M]]
		+	[[Category: Kaila VRI]]
		+	[[Category: Ruehl M]]
		+	[[Category: Schmalhofer M]]
		+	[[Category: Zhou Q]]

OCA: Protected "6smo" [edit=sysop:move=sysop]

OCA — Wed, 28 Aug 2019 13:58:29 GMT

Protected "6smo" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:58, 28 August 2019

OCA: New page: '''Unreleased structure''' The entry 6smo is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Aug 2019 13:58:28 GMT

New page: '''Unreleased structure''' The entry 6smo is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6smo is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]