6spz - Revision history

OCA at 12:45, 24 January 2024

OCA — Wed, 24 Jan 2024 12:45:38 GMT

←Older revision		Revision as of 12:45, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6spz' size='340' side='right'caption='[[6spz]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='6spz' size='340' side='right'caption='[[6spz]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6spz]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SPZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6SPZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6spz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SPZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.08Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6spv\|6spv]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">DLG4, PSD95 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6spz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6spz OCA], [https://pdbe.org/6spz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6spz RCSB], [https://www.ebi.ac.uk/pdbsum/6spz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6spz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6spz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6spz OCA], [~~http~~://pdbe.org/6spz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6spz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6spz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6spz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).	+	[https://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6spz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6spz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Postsynaptic density protein 3D structures\|Postsynaptic density protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Levy~~, C W~~]]	+	[[Category: Levy CW]]
-	[[Category: Prince~~, S M~~]]	+	[[Category: Prince SM]]
-	[[Category: Rodzli, N]]	+	[[Category: Rodzli N]]
-	~~[[Category: Clustering]]~~	+
-	~~[[Category: Membrane associated]]~~	+
-	~~[[Category: Protein-complex]]~~	+
-	~~[[Category: Psd-95 fragment]]~~	+
-	~~[[Category: Receptor-binding]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 11:29, 22 July 2020

OCA — Wed, 22 Jul 2020 11:29:14 GMT

←Older revision		Revision as of 11:29, 22 July 2020
Line 3:		Line 3:
	<StructureSection load='6spz' size='340' side='right'caption='[[6spz]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='6spz' size='340' side='right'caption='[[6spz]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6spz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SPZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6SPZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6spz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SPZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SPZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6spv\|6spv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6spv\|6spv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6spz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6spz OCA], [http://pdbe.org/6spz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6spz RCSB], [http://www.ebi.ac.uk/pdbsum/6spz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6spz ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DLG4, PSD95 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6spz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6spz OCA], [http://pdbe.org/6spz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6spz RCSB], [http://www.ebi.ac.uk/pdbsum/6spz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6spz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).		[[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PSD-95 is a member of the membrane-associated guanylate kinase class of proteins that forms scaffolding interactions with partner proteins, including ion and receptor channels. PSD-95 is directly implicated in modulating the electrical responses of excitable cells. The first two PSD-95/disks large/zona occludens (PDZ) domains of PSD-95 have been shown to be the key component in the formation of channel clusters. We report crystal structures of this dual domain in both apo- and ligand-bound form: thermodynamic analysis of the ligand association and small-angle x-ray scattering of the dual domain in the absence and presence of ligands. These experiments reveal that the ligated double domain forms a three-dimensional scaffold that can be described by a space group. The concentration of the components in this study is comparable with those found in compartments of excitable cells such as the postsynaptic density and juxtaparanodes of Ranvier. These in vitro experiments inform the basis of the scaffolding function of PSD-95 and provide a detailed model for scaffold formation by the PDZ domains of PSD-95.
		+
		+	The Dual PDZ Domain from Postsynaptic Density Protein 95 Forms a Scaffold with Peptide Ligand.,Rodzli NA, Lockhart-Cairns MP, Levy CW, Chipperfield J, Bird L, Baldock C, Prince SM Biophys J. 2020 Jun 26. pii: S0006-3495(20)30494-X. doi:, 10.1016/j.bpj.2020.06.018. PMID:32652058<ref>PMID:32652058</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6spz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Levy, C W]]		[[Category: Levy, C W]]

OCA: Protected "6spz" [edit=sysop:move=sysop]

OCA — Wed, 02 Oct 2019 10:43:36 GMT

Protected "6spz" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:43, 2 October 2019

OCA: New page: ==Crystal structure of PDZ1-2 from PSD-95 with peptide ligand sequence RRESEI bound to both domains== == Structural highlights ==
<table><tr><td colspan='2'>[[6spz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SPZ OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SPZ FirstGlance]. 
</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[6spv|6spv]]</td></tr>
<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6spz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6spz OCA], [http://pdbe.org/6spz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6spz RCSB], [http://www.ebi.ac.uk/pdbsum/6spz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6spz ProSAT]</td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
TOC
</StructureSection>
[[Category: Large Structures]]
[[Category: Levy, C W]]
[[Category: Prince, S M]]
[[Category: Rodzli, N]]
[[Category: Clustering]]
[[Category: Membrane associated]]
[[Category: Protein-complex]]
[[Category: Psd-95 fragment]]
[[Category: Receptor-binding]]
[[Category: Structural protein]]