OCA at 12:46, 24 January 2024

OCA — Wed, 24 Jan 2024 12:46:34 GMT

←Older revision		Revision as of 12:46, 24 January 2024
Line 1:		Line 1:

	==Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2117==		==Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2117==
-	<StructureSection load='6srh' size='340' side='right'caption='[[6srh]]' scene=''>	+	<StructureSection load='6srh' size='340' side='right'caption='[[6srh]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SRH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6SRH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6srh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SRH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6srh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6srh OCA], [~~http~~://pdbe.org/6srh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6srh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6srh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6srh ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.25Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LU8:4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine'>LU8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6srh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6srh OCA], [https://pdbe.org/6srh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6srh RCSB], [https://www.ebi.ac.uk/pdbsum/6srh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6srh ProSAT]</span></td></tr>
	</table>		</table>
-		+	== Disease ==
-	==~~See Also~~==	+	[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] Fibrodysplasia ossificans progressiva. Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:[https://omim.org/entry/135100 135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.<ref>PMID:16642017</ref> <ref>PMID:19085907</ref> <ref>PMID:19330033</ref>
-	*[[~~Activin receptor\|Activin receptor~~]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Adamson RJ]]		[[Category: Adamson RJ]]

OCA: Protected "6srh" [edit=sysop:move=sysop]

OCA — Wed, 06 May 2020 10:46:32 GMT

Protected "6srh" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:46, 6 May 2020

OCA: New page: ==Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2117== == Structural highl...

OCA — Wed, 06 May 2020 10:46:31 GMT

New page: ==Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2117== <StructureSection load='6srh' size='340' side='right'caption='6srh' scene=''> == Structural highl...

New page

==Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2117==
<StructureSection load='6srh' size='340' side='right'caption='[[6srh]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SRH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SRH FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6srh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6srh OCA], [http://pdbe.org/6srh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6srh RCSB], [http://www.ebi.ac.uk/pdbsum/6srh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6srh ProSAT]</span></td></tr>
</table>

==See Also==
*[[Activin receptor|Activin receptor]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Adamson RJ]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Bullock AN]]
[[Category: Burgess-Brown N]]
[[Category: Edwards AM]]
[[Category: Smil D]]
[[Category: Williams EP]]
[[Category: Von Delft F]]

6srh - Revision history

OCA at 12:46, 24 January 2024

OCA: Protected "6srh" [edit=sysop:move=sysop]

OCA: New page: ==Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2117== == Structural highl...