6ssp - Revision history

OCA at 12:47, 24 January 2024

OCA — Wed, 24 Jan 2024 12:47:16 GMT

←Older revision		Revision as of 12:47, 24 January 2024
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	<StructureSection load='6ssp' size='340' side='right'caption='[[6ssp]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='6ssp' size='340' side='right'caption='[[6ssp]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ssp]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"erwinia_carotovora_var._chrysanthemi"_(burkholder_et_al._1953)_dye_1969 "erwinia carotovora var.~~ chrysanthemi~~" (burkholder et al. 1953) dye 1969~~] and [~~http~~://en.wikipedia.org/wiki/~~Camelus_glama Camelus~~ glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SSP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6SSP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ssp]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Dickeya_chrysanthemi Dickeya chrysanthemi] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SSP FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.25Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[6ssi\|6ssi]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ssp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ssp OCA], [~~http~~://pdbe.org/6ssp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ssp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ssp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ssp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ssp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ssp OCA], [https://pdbe.org/6ssp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ssp RCSB], [https://www.ebi.ac.uk/pdbsum/6ssp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ssp ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ELIC_DICCH ELIC_DICCH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Camelus~~ glama]]	+	[[Category: Dickeya chrysanthemi]]
		+	[[Category: Lama glama]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brams, M]]	+	[[Category: Brams M]]
-	[[Category: Evans~~, G L~~]]	+	[[Category: Evans GL]]
-	[[Category: Govaerts, C]]	+	[[Category: Govaerts C]]
-	[[Category: Pardon, E]]	+	[[Category: Pardon E]]
-	[[Category: Spurny, R]]	+	[[Category: Spurny R]]
-	[[Category: Steyaert, J]]	+	[[Category: Steyaert J]]
-	[[Category: Ulens, C]]	+	[[Category: Ulens C]]
-	~~[[Category: Cys-loop receptor]]~~	+
-	~~[[Category: Elic]]~~	+
-	~~[[Category: Nanobody]]~~	+
-	~~[[Category: Pentameric ligand gated ion channel]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 07:35, 30 September 2020

OCA — Wed, 30 Sep 2020 07:35:44 GMT

←Older revision		Revision as of 07:35, 30 September 2020
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	<StructureSection load='6ssp' size='340' side='right'caption='[[6ssp]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='6ssp' size='340' side='right'caption='[[6ssp]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ssp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"erwinia_carotovora_var._chrysanthemi"_(burkholder_et_al._1953)_dye_1969 "erwinia carotovora var. chrysanthemi" (burkholder et al. 1953) dye 1969] and [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SSP OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6SSP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ssp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"erwinia_carotovora_var._chrysanthemi"_(burkholder_et_al._1953)_dye_1969 "erwinia carotovora var. chrysanthemi" (burkholder et al. 1953) dye 1969] and [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SSP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SSP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6ssi\|6ssi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6ssi\|6ssi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ssp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ssp OCA], [http://pdbe.org/6ssp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ssp RCSB], [http://www.ebi.ac.uk/pdbsum/6ssp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ssp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ssp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ssp OCA], [http://pdbe.org/6ssp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ssp RCSB], [http://www.ebi.ac.uk/pdbsum/6ssp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ssp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 6ssp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6ssp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:34, 19 February 2020

OCA — Wed, 19 Feb 2020 07:34:03 GMT

←Older revision		Revision as of 07:34, 19 February 2020
Line 3:		Line 3:
	<StructureSection load='6ssp' size='340' side='right'caption='[[6ssp]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='6ssp' size='340' side='right'caption='[[6ssp]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ssp]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SSP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ssp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"erwinia_carotovora_var._chrysanthemi"_(burkholder_et_al._1953)_dye_1969 "erwinia carotovora var. chrysanthemi" (burkholder et al. 1953) dye 1969] and [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SSP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6ssi\|6ssi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6ssi\|6ssi]]</td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Camelus glama]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Brams, M]]		[[Category: Brams, M]]

OCA at 04:25, 13 February 2020

OCA — Thu, 13 Feb 2020 04:25:03 GMT

←Older revision		Revision as of 04:25, 13 February 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6ssp is ~~ON HOLD~~	+	==Structure of the pentameric ligand-gated ion channel ELIC in complex with a NAM nanobody==
		+	<StructureSection load='6ssp' size='340' side='right'caption='[[6ssp]], [[Resolution\|resolution]] 3.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ssp]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SSP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6ssi\|6ssi]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ssp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ssp OCA], [http://pdbe.org/6ssp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ssp RCSB], [http://www.ebi.ac.uk/pdbsum/6ssp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ssp ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but modify coupling of ligand binding to channel opening. In this study, we developed nanobodies (single domain antibodies), which are functionally active as allosteric modulators, and solved co-crystal structures of the prokaryote (Erwinia) channel ELIC bound either to a positive or a negative allosteric modulator. The allosteric nanobody binding sites partially overlap with those of small molecule modulators, including a vestibule binding site that is not accessible in some pLGICs. Using mutagenesis, we extrapolate the functional importance of the vestibule binding site to the human 5-HT3 receptor, suggesting a common mechanism of modulation in this protein and ELIC. Thus we identify key elements of allosteric binding sites, and extend drug design possibilities in pLGICs with an accessible vestibule site.

-	~~Authors~~:	+	Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site.,Brams M, Govaerts C, Kambara K, Price KL, Spurny R, Gharpure A, Pardon E, Evans GL, Bertrand D, Lummis SC, Hibbs RE, Steyaert J, Ulens C Elife. 2020 Jan 28;9. pii: 51511. doi: 10.7554/eLife.51511. PMID:31990273<ref>PMID:31990273</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6ssp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Brams, M]]
		+	[[Category: Evans, G L]]
		+	[[Category: Govaerts, C]]
		+	[[Category: Pardon, E]]
		+	[[Category: Spurny, R]]
		+	[[Category: Steyaert, J]]
		+	[[Category: Ulens, C]]
		+	[[Category: Cys-loop receptor]]
		+	[[Category: Elic]]
		+	[[Category: Nanobody]]
		+	[[Category: Pentameric ligand gated ion channel]]
		+	[[Category: Transport protein]]

OCA: Protected "6ssp" [edit=sysop:move=sysop]

OCA — Wed, 02 Oct 2019 07:42:21 GMT

Protected "6ssp" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:42, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6ssp is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Oct 2019 07:42:19 GMT

New page: '''Unreleased structure''' The entry 6ssp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ssp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]