6sx4 - Revision history

OCA at 11:30, 22 July 2020

OCA — Wed, 22 Jul 2020 11:30:16 GMT

←Older revision		Revision as of 11:30, 22 July 2020
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	<StructureSection load='6sx4' size='340' side='right'caption='[[6sx4]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6sx4' size='340' side='right'caption='[[6sx4]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sx4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SX4 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6SX4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sx4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SX4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SX4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6swz\|6swz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6swz\|6swz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6sx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sx4 OCA], [http://pdbe.org/6sx4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sx4 RCSB], [http://www.ebi.ac.uk/pdbsum/6sx4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sx4 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">csp1, cop1, Cgl2875, cg3182 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1718 "Micrococcus glutamicus" Kinoshita et al. 1958])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sx4 OCA], [http://pdbe.org/6sx4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sx4 RCSB], [http://www.ebi.ac.uk/pdbsum/6sx4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sx4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Micrococcus glutamicus kinoshita et al. 1958]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bayan, N]]		[[Category: Bayan, N]]

OCA at 06:49, 4 March 2020

OCA — Wed, 04 Mar 2020 06:49:47 GMT

←Older revision		Revision as of 06:49, 4 March 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6sx4 is ~~ON HOLD~~	+	==Structure of C. glutamicum mycoloyltransferase A==
		+	<StructureSection load='6sx4' size='340' side='right'caption='[[6sx4]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6sx4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SX4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6swz\|6swz]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sx4 OCA], [http://pdbe.org/6sx4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sx4 RCSB], [http://www.ebi.ac.uk/pdbsum/6sx4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sx4 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CSP1_CORGL CSP1_CORGL]] One of the two major secreted proteins.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The genomes of Corynebacteriales contain several genes encoding mycoloyltransferases (Myt) that are specific cell envelope enzymes essential for the biogenesis of the outer membrane. MytA is a major mycoloyltransferase of Corynebacterium glutamicum, displaying an N-terminal domain with esterase activity and a C-terminal extension containing a conserved repeated LGFP sequence motif of unknown function. This motif is highly conserved in Corynebacteriales and found associated with cell wall hydrolases and with proteins of unknown function. In this study, we determined the crystal structure of MytA and found that its C-terminal domain is composed of five LGFP motifs and forms a long stalk perpendicular to the N-terminal catalytic alpha/beta-hydrolase domain. The LGFP motifs are composed of a 4-stranded beta-fold and occupy alternating orientations along the axis of the stalk. Multiple acetate binding pockets were identified in the stalk, which could correspond to putative ligand binding sites. By using various MytA mutants and complementary in vitro and in vivo approaches, we provide evidence that the C-terminal LGFP domain interacts with the cell wall peptidoglycan-arabinogalactan polymer. We also show that the C-terminal LGFP domain is not required for the activity of MytA but rather contributes to the overall integrity of the cell envelope.

-	~~Authors:~~ Li de la Sierra-Gallay, I., ~~Van tilbeurgh~~, H., Bayan, N.	+	The C-terminal domain of Corynebacterium glutamicum mycoloyltransferase A is composed of five repeated motifs involved in cell wall binding and stability.,Dietrich C, Li de la Sierra-Gallay I, Masi M, Girard E, Dautin N, Constantinesco-Becker F, Tropis M, Daffe M, van Tilbeurgh H, Bayan N Mol Microbiol. 2020 Feb 19. doi: 10.1111/mmi.14492. PMID:32073722<ref>PMID:32073722</ref>

-	~~Description: Structure~~ of C. ~~glutamicum mycoloyltransferase A~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Li De La Sierra-Gallay, I]]~~	+	<div class="pdbe-citations 6sx4" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Van Tilbeurgh, H~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bayan, N]]		[[Category: Bayan, N]]
		+	[[Category: Sierra-Gallay, I Li de la]]
		+	[[Category: Tilbeurgh, H Van]]
		+	[[Category: Cell wall]]
		+	[[Category: Mycolic acid]]
		+	[[Category: Mycoloyltransferase]]
		+	[[Category: Transferase]]

OCA: Protected "6sx4" [edit=sysop:move=sysop]

OCA — Wed, 02 Oct 2019 07:58:05 GMT

Protected "6sx4" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:58, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6sx4 is ON HOLD Authors: Li de la Sierra-Gallay, I., Van tilbeurgh, H., Bayan, N. Description: Structure of C. glutamicum mycoloyltransferase A [[C...

OCA — Wed, 02 Oct 2019 07:58:03 GMT

New page: '''Unreleased structure''' The entry 6sx4 is ON HOLD Authors: Li de la Sierra-Gallay, I., Van tilbeurgh, H., Bayan, N. Description: Structure of C. glutamicum mycoloyltransferase A [[C...

New page

'''Unreleased structure'''

The entry 6sx4 is ON HOLD

Authors: Li de la Sierra-Gallay, I., Van tilbeurgh, H., Bayan, N.

Description: Structure of C. glutamicum mycoloyltransferase A
[[Category: Unreleased Structures]]
[[Category: Li De La Sierra-Gallay, I]]
[[Category: Van Tilbeurgh, H]]
[[Category: Bayan, N]]