6sxo - Revision history

OCA at 10:16, 22 May 2024

OCA — Wed, 22 May 2024 10:16:50 GMT

←Older revision		Revision as of 10:16, 22 May 2024
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	<SX load='6sxo' size='340' side='right' viewer='molstar' caption='[[6sxo]], [[Resolution\|resolution]] 3.30Å' scene=''>		<SX load='6sxo' size='340' side='right' viewer='molstar' caption='[[6sxo]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sxo]] is a 8 chain structure with sequence from [~~http://en.wikipedia.org/wiki/ ] and [http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SXO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6SXO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sxo]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SXO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6sxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sxo OCA], [~~http~~://pdbe.org/6sxo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6sxo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6sxo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6sxo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sxo OCA], [https://pdbe.org/6sxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sxo RCSB], [https://www.ebi.ac.uk/pdbsum/6sxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sxo ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/RL26_HUMAN RL26_HUMAN]] Diamond-Blackfan anemia 11 (DBA11) [MIM:[http://omim.org/entry/614900 614900]]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22431104</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PA2G4_HUMAN PA2G4_HUMAN]] May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity).<ref>PMID:11268000</ref> <ref>PMID:12682367</ref> <ref>PMID:15064750</ref> <ref>PMID:15583694</ref> ~~[[http://www.uniprot.org/uniprot/RL23A_HUMAN RL23A_HUMAN]] This protein binds to a specific region on the 26S rRNA (By similarity).~~	+	[https://www.uniprot.org/uniprot/PA2G4_HUMAN PA2G4_HUMAN] May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity).<ref>PMID:11268000</ref> <ref>PMID:12682367</ref> <ref>PMID:15064750</ref> <ref>PMID:15583694</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aleksic, M]]	+	[[Category: Aleksic M]]
-	[[Category: Pfeffer, M]]	+	[[Category: Pfeffer M]]
-	[[Category: Sinning, I]]	+	[[Category: Sinning I]]
-	[[Category: Wild, K]]	+	[[Category: Wild K]]
-	~~[[Category: Expansion segment es27l]]~~	+
-	~~[[Category: Human ebp1]]~~	+
-	~~[[Category: Met-ap homolog]]~~	+
-	~~[[Category: Pa2g4 family]]~~	+
-	~~[[Category: Ribosome~~]]	+

OCA at 06:19, 11 April 2020

OCA — Sat, 11 Apr 2020 06:19:48 GMT

←Older revision		Revision as of 06:19, 11 April 2020
Line 3:		Line 3:
	<SX load='6sxo' size='340' side='right' viewer='molstar' caption='[[6sxo]], [[Resolution\|resolution]] 3.30Å' scene=''>		<SX load='6sxo' size='340' side='right' viewer='molstar' caption='[[6sxo]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sxo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SXO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6SXO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sxo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SXO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SXO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6sxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sxo OCA], [http://pdbe.org/6sxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sxo RCSB], [http://www.ebi.ac.uk/pdbsum/6sxo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sxo ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sxo OCA], [http://pdbe.org/6sxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sxo RCSB], [http://www.ebi.ac.uk/pdbsum/6sxo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sxo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 00:55, 7 March 2020

OCA — Sat, 07 Mar 2020 00:55:58 GMT

←Older revision		Revision as of 00:55, 7 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of the human Ebp1-ribosome complex==		==Cryo-EM structure of the human Ebp1-ribosome complex==
-	<~~StructureSection~~ load='6sxo' size='340' side='right'caption='[[6sxo]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<SX load='6sxo' size='340' side='right' viewer='molstar' caption='[[6sxo]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6sxo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SXO FirstGlance]. <br>		<table><tr><td colspan='2'>[[6sxo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SXO FirstGlance]. <br>
Line 22:		Line 22:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 06:36, 19 February 2020

OCA — Wed, 19 Feb 2020 06:36:00 GMT

←Older revision		Revision as of 06:36, 19 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~6sxo~~ is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Cryo-EM structure of the human Ebp1-ribosome complex==
		+	<StructureSection load='6sxo' size='340' side='right'caption='[[6sxo]], [[Resolution\|resolution]] 3.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6sxo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SXO FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sxo OCA], [http://pdbe.org/6sxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sxo RCSB], [http://www.ebi.ac.uk/pdbsum/6sxo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sxo ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/RL26_HUMAN RL26_HUMAN]] Diamond-Blackfan anemia 11 (DBA11) [MIM:[http://omim.org/entry/614900 614900]]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22431104</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PA2G4_HUMAN PA2G4_HUMAN]] May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity).<ref>PMID:11268000</ref> <ref>PMID:12682367</ref> <ref>PMID:15064750</ref> <ref>PMID:15583694</ref> [[http://www.uniprot.org/uniprot/RL23A_HUMAN RL23A_HUMAN]] This protein binds to a specific region on the 26S rRNA (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human Ebp1 is a member of the proliferation-associated 2G4 (PA2G4) family and plays an important role in cancer regulation. Ebp1 shares the methionine aminopeptidase (MetAP) fold and binds to mature 80S ribosomes for translational control. Here, we present a cryo-EM single particle analysis reconstruction of Ebp1 bound to non-translating human 80S ribosomes at a resolution range from 3.3 to ~8 A. Ebp1 blocks the tunnel exit with major interactions to the general uL23/uL29 docking site for nascent chain-associated factors complemented by eukaryote-specific eL19 and rRNA helix H59. H59 is defined as dynamic adaptor undergoing significant remodeling upon Ebp1 binding. Ebp1 recruits rRNA expansion segment ES27L to the tunnel exit via specific interactions with rRNA consensus sequences. The Ebp1-ribosome complex serves as a template for MetAP binding and provides insights into the structural principles for spatial coordination of co-translational events and molecular triage at the ribosomal tunnel exit.

-	~~Authors~~:	+	MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments.,Wild K, Aleksic M, Lapouge K, Juaire KD, Flemming D, Pfeffer S, Sinning I Nat Commun. 2020 Feb 7;11(1):776. doi: 10.1038/s41467-020-14603-7. PMID:32034140<ref>PMID:32034140</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6sxo" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Aleksic, M]]
		+	[[Category: Pfeffer, M]]
		+	[[Category: Sinning, I]]
		+	[[Category: Wild, K]]
		+	[[Category: Expansion segment es27l]]
		+	[[Category: Human ebp1]]
		+	[[Category: Met-ap homolog]]
		+	[[Category: Pa2g4 family]]
		+	[[Category: Ribosome]]

OCA at 13:51, 22 January 2020

OCA — Wed, 22 Jan 2020 13:51:20 GMT

←Older revision		Revision as of 13:51, 22 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6sxo is ON HOLD	+	The entry 6sxo is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 04:55, 23 October 2019

OCA — Wed, 23 Oct 2019 04:55:30 GMT

←Older revision		Revision as of 04:55, 23 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6sxo is ON HOLD ~~until sometime in the future~~	+	The entry 6sxo is ON HOLD

	Authors:		Authors:

OCA: Protected "6sxo" [edit=sysop:move=sysop]

OCA — Wed, 02 Oct 2019 08:00:09 GMT

Protected "6sxo" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:00, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6sxo is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Oct 2019 08:00:08 GMT

New page: '''Unreleased structure''' The entry 6sxo is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6sxo is ON HOLD until sometime in the future

Authors:

Description:
[[Category: Unreleased Structures]]