6sxw - Revision history

OCA at 12:50, 24 January 2024

OCA — Wed, 24 Jan 2024 12:50:01 GMT

←Older revision		Revision as of 12:50, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6sxw' size='340' side='right'caption='[[6sxw]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='6sxw' size='340' side='right'caption='[[6sxw]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sxw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SXW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6SXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SXW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.751Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6sxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sxw OCA], [~~http~~://pdbe.org/6sxw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6sxw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6sxw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6sxw ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sxw OCA], [https://pdbe.org/6sxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sxw RCSB], [https://www.ebi.ac.uk/pdbsum/6sxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sxw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ZN638_HUMAN ZN638_HUMAN]] Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:8647861, PubMed:30487602). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity).[UniProtKB:Q61464]<ref>PMID:30487602</ref> <ref>PMID:8647861</ref>	+	[https://www.uniprot.org/uniprot/ZN638_HUMAN ZN638_HUMAN] Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:8647861, PubMed:30487602). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity).[UniProtKB:Q61464]<ref>PMID:30487602</ref> <ref>PMID:8647861</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aitkenhead, H]]	+	[[Category: Aitkenhead H]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Burgess-Brown~~, N A]]~~	+	[[Category: Burgess-Brown NA]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Gileadi O]]
-	[[Category: Gileadi, O]]	+	[[Category: Newman JA]]
-	[[Category: Newman~~, J A~~]]	+	[[Category: Wang D]]
-	[[Category: Wang, D]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Rna binding]]~~	+
-	~~[[Category: Rrm]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Zinc finger~~]]	+

OCA at 06:04, 16 October 2019

OCA — Wed, 16 Oct 2019 06:04:55 GMT

←Older revision		Revision as of 06:04, 16 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6sxw is ON HOLD~~	+	==Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638)==
-		+	<StructureSection load='6sxw' size='340' side='right'caption='[[6sxw]], [[Resolution\|resolution]] 2.75Å' scene=''>
-	~~Authors: Newman, J.A., Aitkenhead, H., Wang, D., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6sxw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SXW FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638)	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[~~Category: Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sxw OCA], [http://pdbe.org/6sxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sxw RCSB], [http://www.ebi.ac.uk/pdbsum/6sxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sxw ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Arrowsmith, C~~.H]]	+	</table>
-	[[~~Category~~: ~~Burgess~~-~~Brown~~, N.A]]	+	== Function ==
-	[[~~Category~~: ~~Wang~~, D]]	+	[[http://www.uniprot.org/uniprot/ZN638_HUMAN ZN638_HUMAN]] Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:8647861, PubMed:30487602). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity).[UniProtKB:Q61464]<ref>PMID:30487602</ref> <ref>PMID:8647861</ref>
-	[[Category: ~~Von Delft, F~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Aitkenhead, H]]		[[Category: Aitkenhead, H]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Burgess-Brown, N A]]
		+	[[Category: Delft, F von]]
		+	[[Category: Edwards, A]]
	[[Category: Gileadi, O]]		[[Category: Gileadi, O]]
-	[[Category: Newman, J.A]]	+	[[Category: Newman, J A]]
-	[[Category: ~~Edwards~~, A]]	+	[[Category: Wang, D]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Rna binding]]
		+	[[Category: Rrm]]
		+	[[Category: Transcription]]
		+	[[Category: Zinc finger]]

OCA: Protected "6sxw" [edit=sysop:move=sysop]

OCA — Wed, 02 Oct 2019 08:00:53 GMT

Protected "6sxw" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:00, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6sxw is ON HOLD Authors: Newman, J.A., Aitkenhead, H., Wang, D., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gil...

OCA — Wed, 02 Oct 2019 08:00:51 GMT

New page: '''Unreleased structure''' The entry 6sxw is ON HOLD Authors: Newman, J.A., Aitkenhead, H., Wang, D., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gil...

New page

'''Unreleased structure'''

The entry 6sxw is ON HOLD

Authors: Newman, J.A., Aitkenhead, H., Wang, D., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.

Description: Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638)
[[Category: Unreleased Structures]]
[[Category: Arrowsmith, C.H]]
[[Category: Burgess-Brown, N.A]]
[[Category: Wang, D]]
[[Category: Von Delft, F]]
[[Category: Aitkenhead, H]]
[[Category: Gileadi, O]]
[[Category: Newman, J.A]]
[[Category: Edwards, A]]
[[Category: Bountra, C]]