OCA at 07:34, 19 February 2020

OCA — Wed, 19 Feb 2020 07:34:40 GMT

←Older revision		Revision as of 07:34, 19 February 2020
Line 3:		Line 3:
	<StructureSection load='6sy9' size='340' side='right'caption='[[6sy9]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6sy9' size='340' side='right'caption='[[6sy9]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sy9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sy9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SY9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sy9 OCA], [http://pdbe.org/6sy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sy9 RCSB], [http://www.ebi.ac.uk/pdbsum/6sy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sy9 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C3926_14995, C3927_13800, D7214_05345, ERS240541_01816, ERS253249_00465, NCTC12000_02932 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sy9 OCA], [http://pdbe.org/6sy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sy9 RCSB], [http://www.ebi.ac.uk/pdbsum/6sy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sy9 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The water-borne bacterium Legionella pneumophila replicates in environmental protozoa and upon inhalation destroys alveolar macrophages, thus causing a potentially fatal pneumonia termed 'Legionnaires' disease'. L. pneumophila employs the Legionella quorum sensing (Lqs) system to control its life cycle, pathogen-host cell interactions, motility and natural competence. Signaling through the Lqs system occurs through the alpha-hydroxyketone compound Legionella autoinducer-1 (LAI-1) and converges on the prototypic response regulator LqsR, which dimerizes upon phosphorylation of the conserved aspartate, D108 . In this study, we determine the high-resolution structure of monomeric LqsR. The structure reveals a receiver domain adopting a canonical (betaalpha)5 fold, which is connected through an additional sixth helix and an extended alpha5-helix to a novel output domain. The two domains delineate a mainly positively charged groove, and the output domain adopts a five-stranded antiparallel beta-sheet fold similar to nucleotide-binding proteins. Structure-based mutagenesis identified amino acids critical for LqsR phosphorylation and dimerization. Upon phosphorylation, the LqsRD172A and LqsRD302N/E303Q mutant proteins dimerized even more readily than wild-type LqsR, and no evidence for semi-phosphorylated heterodimers was obtained. Taken together, the high-resolution structure of LqsR reveals functionally relevant amino acid residues implicated in signal transduction of the prototypic response regulator.
		+
		+	The structure of the Legionella response regulator LqsR reveals amino acids critical for phosphorylation and dimerization.,Hochstrasser R, Hutter CAJ, Arnold FM, Barlocher K, Seeger MA, Hilbi H Mol Microbiol. 2020 Jan 29. doi: 10.1111/mmi.14477. PMID:31997467<ref>PMID:31997467</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6sy9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 33152]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arnold, F M]]		[[Category: Arnold, F M]]

OCA at 08:10, 5 February 2020

OCA — Wed, 05 Feb 2020 08:10:50 GMT

←Older revision		Revision as of 08:10, 5 February 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6sy9 is ~~ON HOLD~~	+	==Structure of the Legionella pneumophila response regulator LqsR==
-		+	<StructureSection load='6sy9' size='340' side='right'caption='[[6sy9]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6sy9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SY9 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sy9 OCA], [http://pdbe.org/6sy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sy9 RCSB], [http://www.ebi.ac.uk/pdbsum/6sy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sy9 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Arnold, F M]]
		+	[[Category: Baerlocher, K]]
		+	[[Category: Hilbi, H]]
		+	[[Category: Hochstrasser, R]]
		+	[[Category: Hutter, C A.J]]
		+	[[Category: Seeger, M A]]
		+	[[Category: Output domain]]
		+	[[Category: Receiver domain]]
		+	[[Category: Response regulator]]
		+	[[Category: Signaling protein]]

OCA: Protected "6sy9" [edit=sysop:move=sysop]

OCA — Thu, 10 Oct 2019 03:42:24 GMT

Protected "6sy9" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:42, 10 October 2019

OCA: New page: '''Unreleased structure''' The entry 6sy9 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 10 Oct 2019 03:42:22 GMT

New page: '''Unreleased structure''' The entry 6sy9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6sy9 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6sy9 - Revision history

OCA at 07:34, 19 February 2020

OCA at 08:10, 5 February 2020

OCA: Protected "6sy9" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6sy9 is ON HOLD Authors: Description: Category: Unreleased Structures