6syt - Revision history

OCA at 10:16, 22 May 2024

OCA — Wed, 22 May 2024 10:16:51 GMT

←Older revision		Revision as of 10:16, 22 May 2024
Line 3:		Line 3:
	<SX load='6syt' size='340' side='right' viewer='molstar' caption='[[6syt]], [[Resolution\|resolution]] 3.45Å' scene=''>		<SX load='6syt' size='340' side='right' viewer='molstar' caption='[[6syt]], [[Resolution\|resolution]] 3.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6syt]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SYT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6SYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6syt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SYT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.45Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~UNK~~:~~UNKNOWN~~'>~~UNK~~</scene><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">SMG1, ATX, KIAA0421, LIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SMG8, ABC2, C17orf71 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SMG9, C19orf61 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6syt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6syt OCA], [https://pdbe.org/6syt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6syt RCSB], [https://www.ebi.ac.uk/pdbsum/6syt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6syt ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6syt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6syt OCA], [~~http~~://pdbe.org/6syt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6syt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6syt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6syt ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/SMG9_HUMAN SMG9_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~SMG9_HUMAN SMG9_HUMAN~~]] Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase ~~complex) and,~~ in ~~the SMG1C complex, is required for the efficient association between SMG1~~ and ~~SMG8 (PubMed:19417104)~~. Plays a role ~~in brain, heart, and eye development (By similarity).[UniProtKB:Q9DB90]<ref>PMID:19417104</ref> [[http://www.uniprot.org/uniprot/SMG8_HUMAN SMG8_HUMAN]] Involved~~ in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. ~~Is recruited~~ by release factors to stalled ribosomes together with ~~SMG1~~ and SMG9 (forming the SMG1C protein kinase complex) and~~, in the SMG1C complex, is required~~ to ~~mediate~~ the ~~recruitment of~~ SMG1 ~~to the ribosome:SURF~~ complex ~~and to suppress SMG1 kinase activity until~~ the ~~ribosome:~~SURF complex ~~locates~~ the exon junction complex (EJC). ~~Acts~~ as a ~~regulator of~~ kinase ~~activity~~.<ref>PMID:~~19417104~~</ref>	+	[https://www.uniprot.org/uniprot/SMG1_HUMAN SMG1_HUMAN] Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.<ref>PMID:11331269</ref> <ref>PMID:11544179</ref> <ref>PMID:15175154</ref> <ref>PMID:16452507</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6syt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6syt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Conti, E]]	+	[[Category: Conti E]]
-	[[Category: Gat, Y]]	+	[[Category: Gat Y]]
-	[[Category: Schuller~~, J M]]~~	+	[[Category: Schuller JM]]
-	~~[[Category: G-fold protein]]~~	+
-	~~[[Category: Ip6]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Nmd]]~~	+
-	~~[[Category: Pikk family]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 06:20, 11 April 2020

OCA — Sat, 11 Apr 2020 06:20:00 GMT

←Older revision		Revision as of 06:20, 11 April 2020
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	<SX load='6syt' size='340' side='right' viewer='molstar' caption='[[6syt]], [[Resolution\|resolution]] 3.45Å' scene=''>		<SX load='6syt' size='340' side='right' viewer='molstar' caption='[[6syt]], [[Resolution\|resolution]] 3.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6syt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SYT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6SYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6syt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SYT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SYT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMG1, ATX, KIAA0421, LIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SMG8, ABC2, C17orf71 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SMG9, C19orf61 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMG1, ATX, KIAA0421, LIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SMG8, ABC2, C17orf71 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SMG9, C19orf61 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6syt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6syt OCA], [http://pdbe.org/6syt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6syt RCSB], [http://www.ebi.ac.uk/pdbsum/6syt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6syt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6syt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6syt OCA], [http://pdbe.org/6syt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6syt RCSB], [http://www.ebi.ac.uk/pdbsum/6syt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6syt ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 00:56, 7 March 2020

OCA — Sat, 07 Mar 2020 00:56:04 GMT

←Older revision		Revision as of 00:56, 7 March 2020
Line 1:		Line 1:

	==Structure of the SMG1-SMG8-SMG9 complex==		==Structure of the SMG1-SMG8-SMG9 complex==
-	<~~StructureSection~~ load='6syt' size='340' side='right'caption='[[6syt]], [[Resolution\|resolution]] 3.45Å' scene=''>	+	<SX load='6syt' size='340' side='right' viewer='molstar' caption='[[6syt]], [[Resolution\|resolution]] 3.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6syt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SYT FirstGlance]. <br>		<table><tr><td colspan='2'>[[6syt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SYT FirstGlance]. <br>
Line 25:		Line 25:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 13:13, 18 December 2019

OCA — Wed, 18 Dec 2019 13:13:50 GMT

←Older revision		Revision as of 13:13, 18 December 2019
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	<StructureSection load='6syt' size='340' side='right'caption='[[6syt]], [[Resolution\|resolution]] 3.45Å' scene=''>		<StructureSection load='6syt' size='340' side='right'caption='[[6syt]], [[Resolution\|resolution]] 3.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6syt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6syt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SYT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMG1, ATX, KIAA0421, LIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SMG8, ABC2, C17orf71 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SMG9, C19orf61 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6syt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6syt OCA], [http://pdbe.org/6syt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6syt RCSB], [http://www.ebi.ac.uk/pdbsum/6syt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6syt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6syt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6syt OCA], [http://pdbe.org/6syt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6syt RCSB], [http://www.ebi.ac.uk/pdbsum/6syt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6syt ProSAT]</span></td></tr>
	</table>		</table>
Line 12:		Line 13:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SMG9_HUMAN SMG9_HUMAN]] Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity).[UniProtKB:Q9DB90]<ref>PMID:19417104</ref> [[http://www.uniprot.org/uniprot/SMG8_HUMAN SMG8_HUMAN]] Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.<ref>PMID:19417104</ref>		[[http://www.uniprot.org/uniprot/SMG9_HUMAN SMG9_HUMAN]] Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity).[UniProtKB:Q9DB90]<ref>PMID:19417104</ref> [[http://www.uniprot.org/uniprot/SMG8_HUMAN SMG8_HUMAN]] Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.<ref>PMID:19417104</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We report the 3.45-A resolution cryo-EM structure of human SMG1-SMG8-SMG9, a phosphatidylinositol-3-kinase (PI(3)K)-related protein kinase (PIKK) complex central to messenger RNA surveillance. Structural and MS analyses reveal the presence of inositol hexaphosphate (InsP6) in the SMG1 kinase. We show that the InsP6-binding site is conserved in mammalian target of rapamycin (mTOR) and potentially other PIKK members, and that it is required for optimal in vitro phosphorylation of both SMG1 and mTOR substrates.
		+
		+	InsP6 binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complex.,Gat Y, Schuller JM, Lingaraju M, Weyher E, Bonneau F, Strauss M, Murray PJ, Conti E Nat Struct Mol Biol. 2019 Dec;26(12):1089-1093. doi: 10.1038/s41594-019-0342-7., Epub 2019 Dec 2. PMID:31792449<ref>PMID:31792449</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6syt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Conti, E]]		[[Category: Conti, E]]

OCA at 15:23, 11 December 2019

OCA — Wed, 11 Dec 2019 15:23:43 GMT

←Older revision		Revision as of 15:23, 11 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~6syt~~ is ~~ON HOLD~~ until ~~Paper Publication~~	+	==Structure of the SMG1-SMG8-SMG9 complex==
-		+	<StructureSection load='6syt' size='340' side='right'caption='[[6syt]], [[Resolution\|resolution]] 3.45Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6syt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SYT FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6syt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6syt OCA], [http://pdbe.org/6syt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6syt RCSB], [http://www.ebi.ac.uk/pdbsum/6syt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6syt ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SMG9_HUMAN SMG9_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SMG9_HUMAN SMG9_HUMAN]] Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity).[UniProtKB:Q9DB90]<ref>PMID:19417104</ref> [[http://www.uniprot.org/uniprot/SMG8_HUMAN SMG8_HUMAN]] Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.<ref>PMID:19417104</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Conti, E]]
		+	[[Category: Gat, Y]]
		+	[[Category: Schuller, J M]]
		+	[[Category: G-fold protein]]
		+	[[Category: Ip6]]
		+	[[Category: Kinase]]
		+	[[Category: Nmd]]
		+	[[Category: Pikk family]]
		+	[[Category: Signaling protein]]

OCA at 04:55, 23 October 2019

OCA — Wed, 23 Oct 2019 04:55:50 GMT

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OCA: Protected "6syt" [edit=sysop:move=sysop]

OCA — Thu, 10 Oct 2019 03:43:46 GMT

Protected "6syt" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:43, 10 October 2019

OCA: New page: '''Unreleased structure''' The entry 6syt is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

OCA — Thu, 10 Oct 2019 03:43:44 GMT

New page: '''Unreleased structure''' The entry 6syt is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6syt is ON HOLD until sometime in the future

Authors:

Description:
[[Category: Unreleased Structures]]