OCA at 12:52, 24 January 2024

OCA — Wed, 24 Jan 2024 12:52:41 GMT

←Older revision		Revision as of 12:52, 24 January 2024
Line 1:		Line 1:

	==PPAR mutant==		==PPAR mutant==
-	<StructureSection load='6t1s' size='340' side='right'caption='[[6t1s]]' scene=''>	+	<StructureSection load='6t1s' size='340' side='right'caption='[[6t1s]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T1S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6t1s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T1S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t1s OCA], [https://pdbe.org/6t1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t1s RCSB], [https://www.ebi.ac.uk/pdbsum/6t1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t1s ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDK:(2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic+acid'>EDK</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t1s OCA], [https://pdbe.org/6t1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t1s RCSB], [https://www.ebi.ac.uk/pdbsum/6t1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t1s ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref> Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[https://omim.org/entry/604367 604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref> Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>
		+
		+	==See Also==
		+	*[[Peroxisome proliferator-activated receptor 3D structures\|Peroxisome proliferator-activated receptor 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Rochel N]]		[[Category: Rochel N]]

OCA at 06:42, 14 April 2021

OCA — Wed, 14 Apr 2021 06:42:35 GMT

←Older revision		Revision as of 06:42, 14 April 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6t1s ~~is ON HOLD until Paper Publication~~	+	==PPAR mutant==
-		+	<StructureSection load='6t1s' size='340' side='right'caption='[[6t1s]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T1S FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t1s OCA], [https://pdbe.org/6t1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t1s RCSB], [https://www.ebi.ac.uk/pdbsum/6t1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t1s ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Rochel N]]

OCA: Protected "6t1s" [edit=sysop:move=sysop]

OCA — Wed, 16 Oct 2019 04:26:33 GMT

Protected "6t1s" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:26, 16 October 2019

OCA: New page: '''Unreleased structure''' The entry 6t1s is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 16 Oct 2019 04:26:31 GMT

New page: '''Unreleased structure''' The entry 6t1s is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6t1s is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

6t1s - Revision history

OCA at 12:52, 24 January 2024

OCA at 06:42, 14 April 2021

OCA: Protected "6t1s" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6t1s is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures