6t23 - Revision history

OCA at 06:21, 11 April 2020

OCA — Sat, 11 Apr 2020 06:21:15 GMT

←Older revision		Revision as of 06:21, 11 April 2020
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	<SX load='6t23' size='340' side='right' viewer='molstar' caption='[[6t23]], [[Resolution\|resolution]] 3.10Å' scene=''>		<SX load='6t23' size='340' side='right' viewer='molstar' caption='[[6t23]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6t23]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T23 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6T23 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6t23]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T23 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T23 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9ZK:(4~{R},7~{R},10~{S},13~{S},15~{E},19~{S})-10-(4-azanylbutyl)-4-(4-hydroxyphenyl)-7-(1~{H}-indol-3-ylmethyl)-8,13,15,19-tetramethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone'>9ZK</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9ZK:(4~{R},7~{R},10~{S},13~{S},15~{E},19~{S})-10-(4-azanylbutyl)-4-(4-hydroxyphenyl)-7-(1~{H}-indol-3-ylmethyl)-8,13,15,19-tetramethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone'>9ZK</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6t1y\|6t1y]], [[6t20\|6t20]], [[6t24\|6t24]], [[6t25\|6t25]], [[5ooc\|5ooc]], [[5ood\|5ood]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6t1y\|6t1y]], [[6t20\|6t20]], [[6t24\|6t24]], [[6t25\|6t25]], [[5ooc\|5ooc]], [[5ood\|5ood]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6t23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t23 OCA], [http://pdbe.org/6t23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t23 RCSB], [http://www.ebi.ac.uk/pdbsum/6t23 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t23 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t23 OCA], [http://pdbe.org/6t23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t23 RCSB], [http://www.ebi.ac.uk/pdbsum/6t23 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t23 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 00:56, 7 March 2020

OCA — Sat, 07 Mar 2020 00:56:40 GMT

←Older revision		Revision as of 00:56, 7 March 2020
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	==Cryo-EM structure of jasplakinolide-stabilized F-actin (aged)==		==Cryo-EM structure of jasplakinolide-stabilized F-actin (aged)==
-	<~~StructureSection~~ load='6t23' size='340' side='right'caption='[[6t23]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<SX load='6t23' size='340' side='right' viewer='molstar' caption='[[6t23]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6t23]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6T23 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6t23]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6T23 FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]

OCA at 06:52, 4 March 2020

OCA — Wed, 04 Mar 2020 06:52:30 GMT

←Older revision		Revision as of 06:52, 4 March 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6t23 is ~~ON HOLD until Paper~~ Publication	+	==Cryo-EM structure of jasplakinolide-stabilized F-actin (aged)==
		+	<StructureSection load='6t23' size='340' side='right'caption='[[6t23]], [[Resolution\|resolution]] 3.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6t23]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6T23 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9ZK:(4~{R},7~{R},10~{S},13~{S},15~{E},19~{S})-10-(4-azanylbutyl)-4-(4-hydroxyphenyl)-7-(1~{H}-indol-3-ylmethyl)-8,13,15,19-tetramethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone'>9ZK</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6t1y\|6t1y]], [[6t20\|6t20]], [[6t24\|6t24]], [[6t25\|6t25]], [[5ooc\|5ooc]], [[5ood\|5ood]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6t23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t23 OCA], [http://pdbe.org/6t23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t23 RCSB], [http://www.ebi.ac.uk/pdbsum/6t23 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t23 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Actin undergoes structural transitions during polymerization, ATP hydrolysis, and subsequent release of inorganic phosphate. Several actin-binding proteins sense specific states during this transition and can thus target different regions of the actin filament. Here, we show in atomic detail that phalloidin, a mushroom toxin that is routinely used to stabilize and label actin filaments, suspends the structural changes in actin, likely influencing its interaction with actin-binding proteins. Furthermore, high-resolution cryoelectron microscopy structures reveal structural rearrangements in F-actin upon inorganic phosphate release in phalloidin-stabilized filaments. We find that the effect of the sponge toxin jasplakinolide differs from the one of phalloidin, despite their overlapping binding site and similar interactions with the actin filament. Analysis of structural conformations of F-actin suggests that stabilizing agents trap states within the natural conformational space of actin.

-	~~Authors~~:	+	Structural Effects and Functional Implications of Phalloidin and Jasplakinolide Binding to Actin Filaments.,Pospich S, Merino F, Raunser S Structure. 2020 Feb 12. pii: S0969-2126(20)30041-1. doi:, 10.1016/j.str.2020.01.014. PMID:32084355<ref>PMID:32084355</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6t23" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Merino, F]]
		+	[[Category: Pospich, S]]
		+	[[Category: Raunser, S]]
		+	[[Category: Cytoskeleton]]
		+	[[Category: Jasplakinolide]]
		+	[[Category: Stabilized actin filament]]
		+	[[Category: Structural protein]]

OCA at 04:56, 23 October 2019

OCA — Wed, 23 Oct 2019 04:56:13 GMT

←Older revision		Revision as of 04:56, 23 October 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6t23 is ON HOLD	+	The entry 6t23 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6t23" [edit=sysop:move=sysop]

OCA — Wed, 16 Oct 2019 04:27:15 GMT

Protected "6t23" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:27, 16 October 2019

OCA: New page: '''Unreleased structure''' The entry 6t23 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 16 Oct 2019 04:27:14 GMT

New page: '''Unreleased structure''' The entry 6t23 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6t23 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]