6t2r - Revision history

OCA at 12:53, 24 January 2024

OCA — Wed, 24 Jan 2024 12:53:29 GMT

←Older revision		Revision as of 12:53, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6t2r' size='340' side='right'caption='[[6t2r]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6t2r' size='340' side='right'caption='[[6t2r]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6t2r]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_43185 Atcc 43185~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T2R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6T2R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6t2r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_caccae Bacteroides caccae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T2R FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>bglA_5, DW190_07485, DW794_15185, DWY26_17235, DWZ35_07795, DXA49_02580, EAJ00_16275, ERS852494_03890 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~47678 ATCC 43185])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Licheninase Licheninase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.73 3.2.1.73]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t2r OCA], [https://pdbe.org/6t2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t2r RCSB], [https://www.ebi.ac.uk/pdbsum/6t2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t2r ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6t2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t2r OCA], [~~http~~://pdbe.org/6t2r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6t2r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6t2r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6t2r ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A174TK78_9BACE A0A174TK78_9BACE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6t2r" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6t2r" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Laminarase 3D structures\|Laminarase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 43185~~]]	+	[[Category: Bacteroides caccae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Licheninase]]~~	+	[[Category: Basle A]]
-	[[Category: Basle, A]]	+	[[Category: Berrington JE]]
-	[[Category: Berrington~~, J E~~]]	+	[[Category: Bolam DN]]
-	[[Category: Bolam~~, D N~~]]	+	[[Category: Brady RR]]
-	[[Category: Brady~~, R R~~]]	+	[[Category: Chater P]]
-	[[Category: Chater, P]]	+	[[Category: Cooke K]]
-	[[Category: Cooke, K]]	+	[[Category: Crouch LI]]
-	[[Category: Crouch~~, L I~~]]	+	[[Category: Doona M]]
-	[[Category: Doona, M]]	+	[[Category: Lamb CA]]
-	[[Category: Lamb~~, C A~~]]	+	[[Category: Liberato MV]]
-	[[Category: Liberato~~, M V~~]]	+	[[Category: Linhardt RJ]]
-	[[Category: Linhardt~~, R J~~]]	+	[[Category: Madubic K]]
-	[[Category: Madubic, K]]	+	[[Category: Needham S]]
-	[[Category: Needham, S]]	+	[[Category: Spence DIR]]
-	[[Category: Spence~~, D I.R~~]]	+	[[Category: Ubranowicz PA]]
-	[[Category: Ubranowicz~~, P A~~]]	+	[[Category: Zhang F]]
-	[[Category: Zhang, F]]	+
-	~~[[Category: Endo beta-galactosidase]]~~	+
-	~~[[Category: Gh16]]~~	+
-	~~[[Category: Human gut microbiota]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mucin degradation]]~~	+
-	~~[[Category: O-glycanase~~]]	+

OCA at 11:30, 26 August 2020

OCA — Wed, 26 Aug 2020 11:30:42 GMT

←Older revision		Revision as of 11:30, 26 August 2020
Line 1:		Line 1:

	==Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown==		==Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown==
-	<StructureSection load='6t2r' size='340' side='right'caption='[[6t2r]]' scene=''>	+	<StructureSection load='6t2r' size='340' side='right'caption='[[6t2r]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T2R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T2R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6t2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43185 Atcc 43185]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T2R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T2R FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t2r OCA], [http://pdbe.org/6t2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t2r RCSB], [http://www.ebi.ac.uk/pdbsum/6t2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t2r ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bglA_5, DW190_07485, DW794_15185, DWY26_17235, DWZ35_07795, DXA49_02580, EAJ00_16275, ERS852494_03890 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=47678 ATCC 43185])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Licheninase Licheninase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.73 3.2.1.73] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t2r OCA], [http://pdbe.org/6t2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t2r RCSB], [http://www.ebi.ac.uk/pdbsum/6t2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t2r ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The thick mucus layer of the gut provides a barrier to infiltration of the underlying epithelia by both the normal microbiota and enteric pathogens. Some members of the microbiota utilise mucin glycoproteins as a nutrient source, but a detailed understanding of the mechanisms used to breakdown these complex macromolecules is lacking. Here we describe the discovery and characterisation of endo-acting enzymes from prominent mucin-degrading bacteria that target the polyLacNAc structures within oligosaccharide side chains of both animal and human mucins. These O-glycanases are part of the large and diverse glycoside hydrolase 16 (GH16) family and are often lipoproteins, indicating that they are surface located and thus likely involved in the initial step in mucin breakdown. These data provide a significant advance in our knowledge of the mechanism of mucin breakdown by the normal microbiota. Furthermore, we also demonstrate the potential use of these enzymes as tools to explore changes in O-glycan structure in a number of intestinal disease states.
		+
		+	Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown.,Crouch LI, Liberato MV, Urbanowicz PA, Basle A, Lamb CA, Stewart CJ, Cooke K, Doona M, Needham S, Brady RR, Berrington JE, Madunic K, Wuhrer M, Chater P, Pearson JP, Glowacki R, Martens EC, Zhang F, Linhardt RJ, Spencer DIR, Bolam DN Nat Commun. 2020 Aug 11;11(1):4017. doi: 10.1038/s41467-020-17847-5. PMID:32782292<ref>PMID:32782292</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6t2r" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 43185]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Basle A]]	+	[[Category: Licheninase]]
-	[[Category: Berrington JE]]	+	[[Category: Basle, A]]
-	[[Category: Bolam DN]]	+	[[Category: Berrington, J E]]
-	[[Category: Brady RR]]	+	[[Category: Bolam, D N]]
-	[[Category: Chater P]]	+	[[Category: Brady, R R]]
-	[[Category: Cooke K]]	+	[[Category: Chater, P]]
-	[[Category: Crouch LI]]	+	[[Category: Cooke, K]]
-	[[Category: Doona M]]	+	[[Category: Crouch, L I]]
-	[[Category: Lamb CA]]	+	[[Category: Doona, M]]
-	[[Category: Liberato MV]]	+	[[Category: Lamb, C A]]
-	[[Category: Linhardt RJ]]	+	[[Category: Liberato, M V]]
-	[[Category: Madubic K]]	+	[[Category: Linhardt, R J]]
-	[[Category: Needham S]]	+	[[Category: Madubic, K]]
-	[[Category: Spence ~~DIR~~]]	+	[[Category: Needham, S]]
-	[[Category: Ubranowicz PA]]	+	[[Category: Spence, D I.R]]
-	[[Category: Zhang F]]	+	[[Category: Ubranowicz, P A]]
		+	[[Category: Zhang, F]]
		+	[[Category: Endo beta-galactosidase]]
		+	[[Category: Gh16]]
		+	[[Category: Human gut microbiota]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mucin degradation]]
		+	[[Category: O-glycanase]]

OCA at 14:05, 8 July 2020

OCA — Wed, 08 Jul 2020 14:05:59 GMT

←Older revision		Revision as of 14:05, 8 July 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6t2r ~~is ON HOLD until Paper Publication~~	+	==Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown==
-		+	<StructureSection load='6t2r' size='340' side='right'caption='[[6t2r]]' scene=''>
-	~~Authors~~: ~~Crouch, L~~.I.~~, Liberato, M~~.V.~~, Ubranowicz, P~~.A.~~, Basle, A~~.~~, Lamb, C~~.A., ~~Cooke, K~~.~~, Doona, M~~.~~, Needham, S~~., ~~Brady, R.R~~., ~~Berrington, J~~.E.~~, Madubic, K~~., ~~Chater, P~~.~~, Zhang, F~~.~~, Linhardt, R.J~~., ~~Spence, D~~.~~I.R., Bolam, D.N~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T2R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T2R FirstGlance]. <br>
-	~~Description: Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t2r OCA], [http://pdbe.org/6t2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t2r RCSB], [http://www.ebi.ac.uk/pdbsum/6t2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t2r ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Bolam, D.N~~]]	+	__TOC__
-	[[Category: ~~Linhardt, R.J~~]]	+	</StructureSection>
-	[[Category: ~~Brady, R.R~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Doona, M~~]]	+	[[Category: Basle A]]
-	[[Category: ~~Cooke, K~~]]	+	[[Category: Berrington JE]]
-	[[Category: ~~Chater, P~~]]	+	[[Category: Bolam DN]]
-	[[Category: ~~Berrington, J.E~~]]	+	[[Category: Brady RR]]
-	[[Category: ~~Madubic, K~~]]	+	[[Category: Chater P]]
-	[[Category: Lamb~~, C.A~~]]	+	[[Category: Cooke K]]
-	[[Category: ~~Needham, S~~]]	+	[[Category: Crouch LI]]
-	[[Category: ~~Spence, D.I.R~~]]	+	[[Category: Doona M]]
-	[[Category: ~~Basle, A~~]]	+	[[Category: Lamb CA]]
-	[[Category: ~~Liberato, M.V~~]]	+	[[Category: Liberato MV]]
-	[[Category: ~~Ubranowicz, P.A~~]]	+	[[Category: Linhardt RJ]]
-	[[Category: ~~Zhang, F~~]]	+	[[Category: Madubic K]]
-	[[Category: ~~Crouch, L.I~~]]	+	[[Category: Needham S]]
		+	[[Category: Spence DIR]]
		+	[[Category: Ubranowicz PA]]
		+	[[Category: Zhang F]]

OCA: Protected "6t2r" [edit=sysop:move=sysop]

OCA — Wed, 16 Oct 2019 04:30:06 GMT

Protected "6t2r" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:30, 16 October 2019

OCA: New page: '''Unreleased structure''' The entry 6t2r is ON HOLD until Paper Publication Authors: Crouch, L.I., Liberato, M.V., Ubranowicz, P.A., Basle, A., Lamb, C.A., Cooke, K., Doona, M., Needha...

OCA — Wed, 16 Oct 2019 04:30:05 GMT

New page: '''Unreleased structure''' The entry 6t2r is ON HOLD until Paper Publication Authors: Crouch, L.I., Liberato, M.V., Ubranowicz, P.A., Basle, A., Lamb, C.A., Cooke, K., Doona, M., Needha...

New page

'''Unreleased structure'''

The entry 6t2r is ON HOLD until Paper Publication

Authors: Crouch, L.I., Liberato, M.V., Ubranowicz, P.A., Basle, A., Lamb, C.A., Cooke, K., Doona, M., Needham, S., Brady, R.R., Berrington, J.E., Madubic, K., Chater, P., Zhang, F., Linhardt, R.J., Spence, D.I.R., Bolam, D.N.

Description: Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown
[[Category: Unreleased Structures]]
[[Category: Bolam, D.N]]
[[Category: Linhardt, R.J]]
[[Category: Brady, R.R]]
[[Category: Doona, M]]
[[Category: Cooke, K]]
[[Category: Chater, P]]
[[Category: Berrington, J.E]]
[[Category: Madubic, K]]
[[Category: Lamb, C.A]]
[[Category: Needham, S]]
[[Category: Spence, D.I.R]]
[[Category: Basle, A]]
[[Category: Liberato, M.V]]
[[Category: Ubranowicz, P.A]]
[[Category: Zhang, F]]
[[Category: Crouch, L.I]]