6t3e - Revision history

OCA at 12:53, 24 January 2024

OCA — Wed, 24 Jan 2024 12:53:53 GMT

←Older revision		Revision as of 12:53, 24 January 2024
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	==Structure of Thermococcus litoralis Delta(1)-pyrroline-2-carboxylate reductase in complex with NADH and L-proline==		==Structure of Thermococcus litoralis Delta(1)-pyrroline-2-carboxylate reductase in complex with NADH and L-proline==
-	<StructureSection load='6t3e' size='340' side='right'caption='[[6t3e]]' scene=''>	+	<StructureSection load='6t3e' size='340' side='right'caption='[[6t3e]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T3E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6T3E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6t3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_litoralis_DSM_5473 Thermococcus litoralis DSM 5473]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T3E FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6t3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t3e OCA], [~~http~~://pdbe.org/6t3e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6t3e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6t3e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6t3e ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t3e OCA], [https://pdbe.org/6t3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t3e RCSB], [https://www.ebi.ac.uk/pdbsum/6t3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t3e ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/H3ZMH3_THELN H3ZMH3_THELN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	L-Hydroxyproline (L-Hyp) is a nonstandard amino acid that is present in certain proteins, in some antibiotics and in the cell-wall components of plants. L-Hyp is the product of the post-translational modification of protein prolines by prolyl hydroxylase enzymes, and the isomers trans-3-hydroxy-L-proline (T3LHyp) and trans-4-hydroxy-L-proline (T4LHyp) are major components of mammalian collagen. T4LHyp follows two distinct degradation pathways in bacteria and mammals, while T3LHyp is metabolized by a two-step metabolic pathway that is conserved in bacteria and mammals, which involves a T3LHyp dehydratase and a Delta(1)-pyrroline-2-carboxylate (Pyr2C) reductase. In order to shed light on the structure and catalysis of the enzyme involved in the second step of the T3LHyp degradation pathway, the crystal structure of Pyr2C reductase from the archaeon Thermococcus litoralis DSM 5473 complexed with NADH and L-proline is presented. The model allows the mapping of the residues involved in cofactor and product binding and represents a valid model for rationalizing the catalysis of Pyr2C reductases.
		+
		+	Structure of Thermococcus litoralis Delta(1)-pyrroline-2-carboxylate reductase in complex with NADH and L-proline.,Ferrario E, Miggiano R, Rizzi M, Ferraris DM Acta Crystallogr D Struct Biol. 2020 May 1;76(Pt 5):496-505. doi:, 10.1107/S2059798320004866. Epub 2020 Apr 29. PMID:32355045<ref>PMID:32355045</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6t3e" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Thermococcus litoralis DSM 5473]]
	[[Category: Ferrario E]]		[[Category: Ferrario E]]
	[[Category: Ferraris DM]]		[[Category: Ferraris DM]]
	[[Category: Miggiano R]]		[[Category: Miggiano R]]
	[[Category: Rizzi M]]		[[Category: Rizzi M]]

OCA at 05:30, 13 May 2020

OCA — Wed, 13 May 2020 05:30:52 GMT

←Older revision		Revision as of 05:30, 13 May 2020
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-	'''Unreleased structure'''

-	~~The entry 6t3e is ON HOLD~~	+	==Structure of Thermococcus litoralis Delta(1)-pyrroline-2-carboxylate reductase in complex with NADH and L-proline==
-		+	<StructureSection load='6t3e' size='340' side='right'caption='[[6t3e]]' scene=''>
-	~~Authors: Ferraris, D.M., Miggiano, R., Ferrario, E., Rizzi, M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T3E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T3E FirstGlance]. <br>
-	~~Description:~~ Structure of Thermococcus litoralis Delta(1)-pyrroline-2-carboxylate reductase in complex with NADH and L-proline	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t3e OCA], [http://pdbe.org/6t3e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t3e RCSB], [http://www.ebi.ac.uk/pdbsum/6t3e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t3e ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Rizzi~~, M]]	+	__TOC__
-	[[Category: Ferrario, E]]	+	</StructureSection>
-	[[Category: Miggiano, R]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ferraris, D.~~M]]	+	[[Category: Ferrario E]]
		+	[[Category: Ferraris DM]]
		+	[[Category: Miggiano R]]
		+	[[Category: Rizzi M]]

OCA at 04:22, 6 May 2020

OCA — Wed, 06 May 2020 04:22:02 GMT

←Older revision		Revision as of 04:22, 6 May 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6t3e is ON HOLD ~~until Paper Publication~~	+	The entry 6t3e is ON HOLD

-	Authors: Ferraris, D.M., Miggiano, R., Rizzi, M.	+	Authors: Ferraris, D.M., Miggiano, R., Ferrario, E., Rizzi, M.

	Description: Structure of Thermococcus litoralis Delta(1)-pyrroline-2-carboxylate reductase in complex with NADH and L-proline		Description: Structure of Thermococcus litoralis Delta(1)-pyrroline-2-carboxylate reductase in complex with NADH and L-proline
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Rizzi, M]]		[[Category: Rizzi, M]]
		+	[[Category: Ferrario, E]]
	[[Category: Miggiano, R]]		[[Category: Miggiano, R]]
	[[Category: Ferraris, D.M]]		[[Category: Ferraris, D.M]]

OCA at 07:24, 30 October 2019

OCA — Wed, 30 Oct 2019 07:24:48 GMT

←Older revision		Revision as of 07:24, 30 October 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6t3e is ON HOLD	+	The entry 6t3e is ON HOLD until Paper Publication

	Authors: Ferraris, D.M., Miggiano, R., Rizzi, M.		Authors: Ferraris, D.M., Miggiano, R., Rizzi, M.

OCA: Protected "6t3e" [edit=sysop:move=sysop]

OCA — Wed, 16 Oct 2019 04:31:48 GMT

Protected "6t3e" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:31, 16 October 2019

OCA: New page: '''Unreleased structure''' The entry 6t3e is ON HOLD Authors: Ferraris, D.M., Miggiano, R., Rizzi, M. Description: Structure of Thermococcus litoralis Delta(1)-pyrroline-2-carboxylate ...

OCA — Wed, 16 Oct 2019 04:31:47 GMT

New page: '''Unreleased structure''' The entry 6t3e is ON HOLD Authors: Ferraris, D.M., Miggiano, R., Rizzi, M. Description: Structure of Thermococcus litoralis Delta(1)-pyrroline-2-carboxylate ...

New page

'''Unreleased structure'''

The entry 6t3e is ON HOLD

Authors: Ferraris, D.M., Miggiano, R., Rizzi, M.

Description: Structure of Thermococcus litoralis Delta(1)-pyrroline-2-carboxylate reductase in complex with NADH and L-proline
[[Category: Unreleased Structures]]
[[Category: Rizzi, M]]
[[Category: Miggiano, R]]
[[Category: Ferraris, D.M]]