6t3o - Revision history

OCA at 12:54, 24 January 2024

OCA — Wed, 24 Jan 2024 12:54:09 GMT

←Older revision		Revision as of 12:54, 24 January 2024
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	<StructureSection load='6t3o' size='340' side='right'caption='[[6t3o]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='6t3o' size='340' side='right'caption='[[6t3o]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6t3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6t3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T3O FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MLZ~~:~~N-METHYL-LYSINE~~'>~~MLZ~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">MYOM1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t3o OCA], [https://pdbe.org/6t3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t3o RCSB], [https://www.ebi.ac.uk/pdbsum/6t3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t3o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t3o OCA], [https://pdbe.org/6t3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t3o RCSB], [https://www.ebi.ac.uk/pdbsum/6t3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t3o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MYOM1_HUMAN MYOM1_HUMAN]] Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.	+	[https://www.uniprot.org/uniprot/MYOM1_HUMAN MYOM1_HUMAN] Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6t3o" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6t3o" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Myomesin\|Myomesin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Duskova, J]]	+	[[Category: Duskova J]]
-	[[Category: Maly, P]]	+	[[Category: Maly P]]
-	[[Category: Petrokova, H]]	+	[[Category: Petrokova H]]
-	~~[[Category: Contractile protein]]~~	+
-	~~[[Category: Scaffold structure]]~~	+
-	~~[[Category: Small protein domain~~]]	+

OCA at 08:54, 29 September 2021

OCA — Wed, 29 Sep 2021 08:54:29 GMT

←Older revision		Revision as of 08:54, 29 September 2021
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-	==Crystal structure of the human myomesin ~~domains~~ 10==	+	==Crystal structure of the human myomesin domain 10==
-	<StructureSection load='6t3o' size='340' side='right'caption='[[6t3o]]' scene=''>	+	<StructureSection load='6t3o' size='340' side='right'caption='[[6t3o]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6t3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T3O FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t3o OCA], [https://pdbe.org/6t3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t3o RCSB], [https://www.ebi.ac.uk/pdbsum/6t3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t3o ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYOM1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t3o OCA], [https://pdbe.org/6t3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t3o RCSB], [https://www.ebi.ac.uk/pdbsum/6t3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t3o ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/MYOM1_HUMAN MYOM1_HUMAN]] Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	One of the proposed strategies for the development of a more efficient HIV-1 vaccine is based on the identification of proteins binding to a paratope of chosen broadly neutralizing antibody (bNAb) that will mimic cognate HIV-1 Env (glyco)protein epitope and could be used as potent immunogens for induction of protective virus-neutralizing antibodies in the immunized individuals. To verify this "non-cognate ligand" concept, we developed a highly complex combinatorial library designed on a scaffold of human myomesin-1 protein domain and selected proteins called Myomedins specifically binding to variable regions of HIV-1 broadly neutralizing antibody 10E8. Immunization of mice with these Myomedin variants elicited the production of HIV-1 Env-specific antibodies. Hyperimmune sera bound to Env pseudotyped viruses and weakly/moderately neutralized 54% of tested clade A, B, C, and AE pseudotyped viruses variants in vitro. These results demonstrate that Myomedin variants have the potential to mimic Env epitopes and could be used as potential HIV-1 vaccine components.
		+
		+	Myomedin scaffold variants targeted to 10E8 HIV-1 broadly neutralizing antibody mimic gp41 epitope and elicit HIV-1 virus-neutralizing sera in mice.,Kuchar M, Kosztyu P, Daniel Liskova V, Cerny J, Petrokova H, Vroblova E, Maly M, Vankova L, Krupka M, Raskova Kafkova L, Turanek Knotigova P, Duskova J, Dohnalek J, Masek J, Turanek J, Raska M, Maly P Virulence. 2021 Dec;12(1):1271-1287. doi: 10.1080/21505594.2021.1920251. PMID:33993840<ref>PMID:33993840</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6t3o" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Duskova J]]	+	[[Category: Duskova, J]]
-	[[Category: Maly P]]	+	[[Category: Maly, P]]
-	[[Category: Petrokova H]]	+	[[Category: Petrokova, H]]
		+	[[Category: Contractile protein]]
		+	[[Category: Scaffold structure]]
		+	[[Category: Small protein domain]]

OCA at 06:41, 17 March 2021

OCA — Wed, 17 Mar 2021 06:41:46 GMT

←Older revision		Revision as of 06:41, 17 March 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6t3o is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the human myomesin domains 10==
-		+	<StructureSection load='6t3o' size='340' side='right'caption='[[6t3o]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T3O FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t3o OCA], [https://pdbe.org/6t3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t3o RCSB], [https://www.ebi.ac.uk/pdbsum/6t3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t3o ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Duskova J]]
		+	[[Category: Maly P]]
		+	[[Category: Petrokova H]]

OCA at 05:08, 6 November 2019

OCA — Wed, 06 Nov 2019 05:08:20 GMT

←Older revision		Revision as of 05:08, 6 November 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6t3o is ON HOLD	+	The entry 6t3o is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6t3o" [edit=sysop:move=sysop]

OCA — Wed, 16 Oct 2019 04:32:32 GMT

Protected "6t3o" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:32, 16 October 2019

OCA: New page: '''Unreleased structure''' The entry 6t3o is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 16 Oct 2019 04:32:30 GMT

New page: '''Unreleased structure''' The entry 6t3o is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6t3o is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]