6t4d - Revision history

OCA at 10:52, 24 December 2020

OCA — Thu, 24 Dec 2020 10:52:02 GMT

←Older revision		Revision as of 10:52, 24 December 2020
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	==Crystal structure of Plasmodium falciparum Morn1==		==Crystal structure of Plasmodium falciparum Morn1==
-	<StructureSection load='6t4d' size='340' side='right'caption='[[6t4d]]' scene=''>	+	<StructureSection load='6t4d' size='340' side='right'caption='[[6t4d]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T4D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T4D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6t4d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T4D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T4D FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t4d OCA], [http://pdbe.org/6t4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t4d RCSB], [http://www.ebi.ac.uk/pdbsum/6t4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t4d ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFFCH_03839 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t4d OCA], [http://pdbe.org/6t4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t4d RCSB], [http://www.ebi.ac.uk/pdbsum/6t4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t4d ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	MORN (Membrane Occupation and Recognition Nexus) repeat proteins have a wide taxonomic distribution, being found in both prokaryotes and eukaryotes. Despite this ubiquity, they remain poorly characterised at both a structural and a functional level compared to other common repeats. In functional terms, they are often assumed to be lipid-binding modules that mediate membrane targeting. We addressed this putative activity by focusing on a protein composed solely of MORN repeats-Trypanosoma brucei MORN1. Surprisingly, no evidence for binding to membranes or lipid vesicles by TbMORN1 could be obtained either in vivo or in vitro. Conversely, TbMORN1 did interact with individual phospholipids. High- and low-resolution structures of the MORN1 protein from Trypanosoma brucei and homologous proteins from the parasites Toxoplasma gondii and Plasmodium falciparum were obtained using a combination of macromolecular crystallography, small-angle X-ray scattering, and electron microscopy. This enabled a first structure-based definition of the MORN repeat itself. Furthermore, all three structures dimerised via their C-termini in an antiparallel configuration. The dimers could form extended or V-shaped quaternary structures depending on the presence of specific interface residues. This work provides a new perspective on MORN repeats, showing that they are protein-protein interaction modules capable of mediating both dimerisation and oligomerisation.
		+
		+	Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats.,Sajko S, Grishkovskaya I, Kostan J, Graewert M, Setiawan K, Trubestein L, Niedermuller K, Gehin C, Sponga A, Puchinger M, Gavin AC, Leonard TA, Svergun DI, Smith TK, Morriswood B, Djinovic-Carugo K PLoS One. 2020 Dec 9;15(12):e0242677. doi: 10.1371/journal.pone.0242677., eCollection 2020. PMID:33296386<ref>PMID:33296386</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6t4d" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Djinovic-Carugo K]]	+	[[Category: Plafa]]
-	[[Category: Grishkovskaya I]]	+	[[Category: Djinovic-Carugo, K]]
-	[[Category: Kostan J]]	+	[[Category: Grishkovskaya, I]]
-	[[Category: Morriswood B]]	+	[[Category: Kostan, J]]
-	[[Category: Sajko S]]	+	[[Category: Morriswood, B]]
		+	[[Category: Sajko, S]]
		+	[[Category: Apicomplexa]]
		+	[[Category: Morn repeat]]
		+	[[Category: Morn1]]
		+	[[Category: Structural protein]]

OCA at 09:33, 18 November 2020

OCA — Wed, 18 Nov 2020 09:33:07 GMT

←Older revision		Revision as of 09:33, 18 November 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6t4d ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of Plasmodium falciparum Morn1==
-		+	<StructureSection load='6t4d' size='340' side='right'caption='[[6t4d]]' scene=''>
-	~~Authors~~: ~~Grishkovskaya~~, I., ~~Kostan, J~~., ~~Sajko, S~~., ~~Morriswood, B~~., ~~Djinovic~~-~~Carugo, K~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T4D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T4D FirstGlance]. <br>
-	~~Description: Crystal structure of Plasmodium falciparum Morn1~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t4d OCA], [http://pdbe.org/6t4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t4d RCSB], [http://www.ebi.ac.uk/pdbsum/6t4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t4d ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Sajko, S~~]]	+	__TOC__
-	[[Category: ~~Djinovic-Carugo, K~~]]	+	</StructureSection>
-	[[Category: Kostan, J]]	+	[[Category: Large Structures]]
-	[[Category: Morriswood, B]]	+	[[Category: Djinovic-Carugo K]]
-	[[Category: ~~Grishkovskaya, I~~]]	+	[[Category: Grishkovskaya I]]
		+	[[Category: Kostan J]]
		+	[[Category: Morriswood B]]
		+	[[Category: Sajko S]]

OCA at 06:05, 22 July 2020

OCA — Wed, 22 Jul 2020 06:05:23 GMT

←Older revision		Revision as of 06:05, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6t4d is ON HOLD	+	The entry 6t4d is ON HOLD until Paper Publication

	Authors: Grishkovskaya, I., Kostan, J., Sajko, S., Morriswood, B., Djinovic-Carugo, K.		Authors: Grishkovskaya, I., Kostan, J., Sajko, S., Morriswood, B., Djinovic-Carugo, K.

OCA: Protected "6t4d" [edit=sysop:move=sysop]

OCA — Wed, 23 Oct 2019 05:00:06 GMT

Protected "6t4d" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:00, 23 October 2019

OCA: New page: '''Unreleased structure''' The entry 6t4d is ON HOLD Authors: Grishkovskaya, I., Kostan, J., Sajko, S., Morriswood, B., Djinovic-Carugo, K. Description: Crystal structure of Plasmodium...

OCA — Wed, 23 Oct 2019 05:00:04 GMT

New page: '''Unreleased structure''' The entry 6t4d is ON HOLD Authors: Grishkovskaya, I., Kostan, J., Sajko, S., Morriswood, B., Djinovic-Carugo, K. Description: Crystal structure of Plasmodium...

New page

'''Unreleased structure'''

The entry 6t4d is ON HOLD

Authors: Grishkovskaya, I., Kostan, J., Sajko, S., Morriswood, B., Djinovic-Carugo, K.

Description: Crystal structure of Plasmodium falciparum Morn1
[[Category: Unreleased Structures]]
[[Category: Sajko, S]]
[[Category: Djinovic-Carugo, K]]
[[Category: Kostan, J]]
[[Category: Morriswood, B]]
[[Category: Grishkovskaya, I]]