OCA at 09:11, 30 October 2019

OCA — Wed, 30 Oct 2019 09:11:07 GMT

←Older revision		Revision as of 09:11, 30 October 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6t51 is ~~ON HOLD~~	+	==NMR structure of KRAS22RT G-quadruplex forming within KRAS promoter region at physological temperature==
		+	<StructureSection load='6t51' size='340' side='right'caption='[[6t51]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6t51]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T51 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6T51 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6t51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t51 OCA], [http://pdbe.org/6t51 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t51 RCSB], [http://www.ebi.ac.uk/pdbsum/6t51 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t51 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Single stranded guanine rich DNA (or RNA) sequences adopt noncanonical secondary structures called G-quadruplexes (G4). Functionally, quadruplexes control gene transcription and regulate activities such as replication, gene recombination or alternative splicing. Hence they are potential targets for cancer, neuronal, and viral related diseases. KRAS is one of the most mutated oncogenes in the genome of cancer cells and contains a nuclease hypersensitive element (NHE) sequence capable of forming G-quadruplexes via its six runs of guanines. In our work, we are interested in the NMR structure of the major G4 scaffold formed in the KRAS NHE region with a mutated sequence of 22 residues. Here, we report (1)H, (13)C and (15)N chemical shift assignments the G4 formed within KRAS22RT sequence.

-	~~Authors: Marquevielle~~, J., Salgado, G.	+	(1)H, (13)C, and (15)N chemical shift assignments of a G-quadruplex forming sequence within the KRAS proto-oncogene promoter region.,Marquevielle J, Kumar MVV, Mergny JL, Salgado GF Biomol NMR Assign. 2018 Apr;12(1):123-127. doi: 10.1007/s12104-017-9793-0. Epub, 2017 Nov 30. PMID:29189986<ref>PMID:29189986</ref>

-	~~Description: NMR structure~~ of ~~KRAS22RT G~~-~~quadruplex forming within KRAS promoter region at physological temperature~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6t51" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Marquevielle, J]]		[[Category: Marquevielle, J]]
	[[Category: Salgado, G]]		[[Category: Salgado, G]]
		+	[[Category: Dna]]
		+	[[Category: G-quadruplex]]
		+	[[Category: Kras oncogene]]
		+	[[Category: Promoter region]]

OCA: Protected "6t51" [edit=sysop:move=sysop]

OCA — Wed, 23 Oct 2019 05:02:16 GMT

Protected "6t51" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:02, 23 October 2019

OCA: New page: '''Unreleased structure''' The entry 6t51 is ON HOLD Authors: Marquevielle, J., Salgado, G. Description: NMR structure of KRAS22RT G-quadruplex forming within KRAS promoter region at p...

OCA — Wed, 23 Oct 2019 05:02:14 GMT

New page: '''Unreleased structure''' The entry 6t51 is ON HOLD Authors: Marquevielle, J., Salgado, G. Description: NMR structure of KRAS22RT G-quadruplex forming within KRAS promoter region at p...

New page

'''Unreleased structure'''

The entry 6t51 is ON HOLD

Authors: Marquevielle, J., Salgado, G.

Description: NMR structure of KRAS22RT G-quadruplex forming within KRAS promoter region at physological temperature
[[Category: Unreleased Structures]]
[[Category: Marquevielle, J]]
[[Category: Salgado, G]]

6t51 - Revision history

OCA at 09:11, 30 October 2019

OCA: Protected "6t51" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6t51 is ON HOLD Authors: Marquevielle, J., Salgado, G. Description: NMR structure of KRAS22RT G-quadruplex forming within KRAS promoter region at p...