6tas - Revision history

OCA at 11:09, 30 March 2022

OCA — Wed, 30 Mar 2022 11:09:50 GMT

←Older revision		Revision as of 11:09, 30 March 2022
Line 3:		Line 3:
	<SX load='6tas' size='340' side='right' viewer='molstar' caption='[[6tas]], [[Resolution\|resolution]] 2.75Å' scene=''>		<SX load='6tas' size='340' side='right' viewer='molstar' caption='[[6tas]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tas]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6TAS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tas]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TAS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Arc1, CG12505 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Arc1, CG12505 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6tas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tas OCA], [~~http~~://pdbe.org/6tas PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tas RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tas PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tas ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tas OCA], [https://pdbe.org/6tas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tas RCSB], [https://www.ebi.ac.uk/pdbsum/6tas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tas ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ARC1_DROME ARC1_DROME]] Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles (PubMed:29328915). Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation (PubMed:29328915). Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction (PubMed:29328915). May play a role in energy balance: required for regulation of body fat by a specific population of brain neurons, named E347, that are necessary and sufficient for proper body fat storage (PubMed:26209258).<ref>PMID:26209258</ref> <ref>PMID:29328915</ref>	+	[[https://www.uniprot.org/uniprot/ARC1_DROME ARC1_DROME]] Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles (PubMed:29328915). Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation (PubMed:29328915). Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction (PubMed:29328915). May play a role in energy balance: required for regulation of body fat by a specific population of brain neurons, named E347, that are necessary and sufficient for proper body fat storage (PubMed:26209258).<ref>PMID:26209258</ref> <ref>PMID:29328915</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:27, 11 April 2020

OCA — Sat, 11 Apr 2020 06:27:15 GMT

←Older revision		Revision as of 06:27, 11 April 2020
Line 3:		Line 3:
	<SX load='6tas' size='340' side='right' viewer='molstar' caption='[[6tas]], [[Resolution\|resolution]] 2.75Å' scene=''>		<SX load='6tas' size='340' side='right' viewer='molstar' caption='[[6tas]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tas]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6TAS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tas]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TAS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Arc1, CG12505 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Arc1, CG12505 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6tas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tas OCA], [http://pdbe.org/6tas PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tas RCSB], [http://www.ebi.ac.uk/pdbsum/6tas PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tas ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tas OCA], [http://pdbe.org/6tas PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tas RCSB], [http://www.ebi.ac.uk/pdbsum/6tas PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tas ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 00:59, 7 March 2020

OCA — Sat, 07 Mar 2020 00:59:31 GMT

←Older revision		Revision as of 00:59, 7 March 2020
Line 1:		Line 1:

	==Structure of the two-fold capsomer of the dArc1 capsid==		==Structure of the two-fold capsomer of the dArc1 capsid==
-	<~~StructureSection~~ load='6tas' size='340' side='right'caption='[[6tas]], [[Resolution\|resolution]] 2.75Å' scene=''>	+	<SX load='6tas' size='340' side='right' viewer='molstar' caption='[[6tas]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6tas]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TAS FirstGlance]. <br>		<table><tr><td colspan='2'>[[6tas]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TAS FirstGlance]. <br>
Line 22:		Line 22:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Drome]]		[[Category: Drome]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 07:37, 19 February 2020

OCA — Wed, 19 Feb 2020 07:37:41 GMT

←Older revision		Revision as of 07:37, 19 February 2020
Line 3:		Line 3:
	<StructureSection load='6tas' size='340' side='right'caption='[[6tas]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='6tas' size='340' side='right'caption='[[6tas]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tas]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TAS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tas]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TAS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Arc1, CG12505 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tas OCA], [http://pdbe.org/6tas PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tas RCSB], [http://www.ebi.ac.uk/pdbsum/6tas PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tas ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tas OCA], [http://pdbe.org/6tas PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tas RCSB], [http://www.ebi.ac.uk/pdbsum/6tas PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tas ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ARC1_DROME ARC1_DROME]] Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles (PubMed:29328915). Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation (PubMed:29328915). Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction (PubMed:29328915). May play a role in energy balance: required for regulation of body fat by a specific population of brain neurons, named E347, that are necessary and sufficient for proper body fat storage (PubMed:26209258).<ref>PMID:26209258</ref> <ref>PMID:29328915</ref>		[[http://www.uniprot.org/uniprot/ARC1_DROME ARC1_DROME]] Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles (PubMed:29328915). Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation (PubMed:29328915). Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction (PubMed:29328915). May play a role in energy balance: required for regulation of body fat by a specific population of brain neurons, named E347, that are necessary and sufficient for proper body fat storage (PubMed:26209258).<ref>PMID:26209258</ref> <ref>PMID:29328915</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.
		+
		+	Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.,Erlendsson S, Morado DR, Cullen HB, Feschotte C, Shepherd JD, Briggs JAG Nat Neurosci. 2020 Feb;23(2):172-175. doi: 10.1038/s41593-019-0569-y. Epub 2020, Jan 6. PMID:31907439<ref>PMID:31907439</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6tas" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Briggs, J A.G]]		[[Category: Briggs, J A.G]]

OCA at 08:25, 1 January 2020

OCA — Wed, 01 Jan 2020 08:25:48 GMT

←Older revision		Revision as of 08:25, 1 January 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6tas is ~~ON HOLD~~	+	==Structure of the two-fold capsomer of the dArc1 capsid==
-		+	<StructureSection load='6tas' size='340' side='right'caption='[[6tas]], [[Resolution\|resolution]] 2.75Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6tas]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TAS FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tas OCA], [http://pdbe.org/6tas PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tas RCSB], [http://www.ebi.ac.uk/pdbsum/6tas PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tas ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ARC1_DROME ARC1_DROME]] Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles (PubMed:29328915). Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation (PubMed:29328915). Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction (PubMed:29328915). May play a role in energy balance: required for regulation of body fat by a specific population of brain neurons, named E347, that are necessary and sufficient for proper body fat storage (PubMed:26209258).<ref>PMID:26209258</ref> <ref>PMID:29328915</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Briggs, J A.G]]
		+	[[Category: Erlendsson, S]]
		+	[[Category: Morado, D R]]
		+	[[Category: Shepherd, J D]]
		+	[[Category: Darc]]
		+	[[Category: Gag]]
		+	[[Category: Virus]]
		+	[[Category: Virus like particle]]
		+	[[Category: Vlp]]

OCA: Protected "6tas" [edit=sysop:move=sysop]

OCA — Wed, 06 Nov 2019 05:15:33 GMT

Protected "6tas" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:15, 6 November 2019

OCA: New page: '''Unreleased structure''' The entry 6tas is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Nov 2019 05:15:31 GMT

New page: '''Unreleased structure''' The entry 6tas is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6tas is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]