6tbf - Revision history

OCA at 12:59, 24 January 2024

OCA — Wed, 24 Jan 2024 12:59:03 GMT

←Older revision		Revision as of 12:59, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6tbf' size='340' side='right'caption='[[6tbf]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='6tbf' size='340' side='right'caption='[[6tbf]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tbf]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Celju Celju~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TBF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tbf]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Cellvibrio_japonicus_Ueda107 Cellvibrio japonicus Ueda107]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TBF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=N0T:(1~{S},2~{S},3~{S},4~{R},5~{R})-4-(hydroxymethyl)-5-(octylamino)cyclopentane-1,2,3-triol'>N0T</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bgl35A, CJA_2707 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=498211 CELJU])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=N0T:(1~{S},2~{S},3~{S},4~{R},5~{R})-4-(hydroxymethyl)-5-(octylamino)cyclopentane-1,2,3-triol'>N0T</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tbf OCA], [https://pdbe.org/6tbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tbf RCSB], [https://www.ebi.ac.uk/pdbsum/6tbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tbf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tbf OCA], [https://pdbe.org/6tbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tbf RCSB], [https://www.ebi.ac.uk/pdbsum/6tbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tbf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B3PBE0_CELJU B3PBE0_CELJU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6tbf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6tbf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Galactosidase 3D structures\|Galactosidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Beta-galactosidase]]~~	+	[[Category: Cellvibrio japonicus Ueda107]]
-	~~[[Category: Celju~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Davies, G]]	+	[[Category: Davies G]]
-	[[Category: Offen, W]]	+	[[Category: Offen W]]
-	~~[[Category: Beta galactosidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibitor~~]]	+

OCA at 14:55, 3 March 2021

OCA — Wed, 03 Mar 2021 14:55:34 GMT

←Older revision		Revision as of 14:55, 3 March 2021
Line 1:		Line 1:

	==Structure of a beta galactosidase with inhibitor==		==Structure of a beta galactosidase with inhibitor==
-	<StructureSection load='6tbf' size='340' side='right'caption='[[6tbf]]' scene=''>	+	<StructureSection load='6tbf' size='340' side='right'caption='[[6tbf]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TBF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6TBF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tbf]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Celju Celju]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TBF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6tbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tbf OCA], [~~http~~://pdbe.org/6tbf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tbf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tbf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tbf ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=N0T:(1~{S},2~{S},3~{S},4~{R},5~{R})-4-(hydroxymethyl)-5-(octylamino)cyclopentane-1,2,3-triol'>N0T</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bgl35A, CJA_2707 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=498211 CELJU])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tbf OCA], [https://pdbe.org/6tbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tbf RCSB], [https://www.ebi.ac.uk/pdbsum/6tbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tbf ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new cyclopentanoid beta-galactosidase inhibitors were prepared and their inhibitory and pharmacological chaperoning activities determined and compared with those of lipophilic analogs of the potent beta-d-galactosidase inhibitor 4-epi-isofagomine. Structure-activity relationships were investigated by X-ray crystallography as well as by alterations in the cyclopentane moiety such as deoxygenation and replacement by fluorine of a "strategic" hydroxyl group. New compounds have revealed highly promising activities with a range of beta-galactosidase-compromised human cell lines and may serve as leads towards new pharmacological chaperones for GM1-gangliosidosis and Morquio B disease.
		+
		+	Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine.,Weber P, Thonhofer M, Averill S, Davies GJ, Santana AG, Muller P, Nasseri SA, Offen WA, Pabst BM, Paschke E, Schalli M, Torvisco A, Tschernutter M, Tysoe C, Windischhofer W, Withers SG, Wolfsgruber A, Wrodnigg TM, Stutz AE Molecules. 2020 Sep 3;25(17). pii: molecules25174025. doi:, 10.3390/molecules25174025. PMID:32899288<ref>PMID:32899288</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6tbf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Beta-galactosidase]]
		+	[[Category: Celju]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Davies G]]	+	[[Category: Davies, G]]
-	[[Category: Offen W]]	+	[[Category: Offen, W]]
		+	[[Category: Beta galactosidase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Inhibitor]]

OCA at 06:19, 19 August 2020

OCA — Wed, 19 Aug 2020 06:19:10 GMT

←Older revision		Revision as of 06:19, 19 August 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6tbf ~~is ON HOLD until Paper Publication~~	+	==Structure of a beta galactosidase with inhibitor==
-		+	<StructureSection load='6tbf' size='340' side='right'caption='[[6tbf]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TBF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TBF FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tbf OCA], [http://pdbe.org/6tbf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tbf RCSB], [http://www.ebi.ac.uk/pdbsum/6tbf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tbf ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Davies G]]
		+	[[Category: Offen W]]

OCA at 06:10, 22 July 2020

OCA — Wed, 22 Jul 2020 06:10:32 GMT

←Older revision		Revision as of 06:10, 22 July 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6tbf is ON HOLD	+	The entry 6tbf is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6tbf" [edit=sysop:move=sysop]

OCA — Wed, 13 Nov 2019 09:25:56 GMT

Protected "6tbf" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:25, 13 November 2019

OCA: New page: '''Unreleased structure''' The entry 6tbf is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Nov 2019 09:25:55 GMT

New page: '''Unreleased structure''' The entry 6tbf is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6tbf is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]