6td9 - Revision history

OCA at 12:46, 16 December 2020

OCA — Wed, 16 Dec 2020 12:46:45 GMT

←Older revision		Revision as of 12:46, 16 December 2020
Line 3:		Line 3:
	<StructureSection load='6td9' size='340' side='right'caption='[[6td9]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='6td9' size='340' side='right'caption='[[6td9]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6td9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TD9 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6TD9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6td9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TD9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TD9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6td9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6td9 OCA], [http://pdbe.org/6td9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6td9 RCSB], [http://www.ebi.ac.uk/pdbsum/6td9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6td9 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA1624 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6td9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6td9 OCA], [http://pdbe.org/6td9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6td9 RCSB], [http://www.ebi.ac.uk/pdbsum/6td9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6td9 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of the 268-residue periplasmic protein PA1624 from the opportunistic pathogen Pseudomonas aeruginosa PAO1 was determined to high resolution using the Se-SAD method for initial phasing. The protein was found to be monomeric and the structure consists of two domains, domains 1 and 2, comprising residues 24-184 and 185-268, respectively. The fold of these domains could not be predicted even using state-of-the-art prediction methods, and similarity searches revealed only a very distant homology to known structures, namely to Mog1p/PsbP-like and OmpA-like proteins for the N- and C-terminal domains, respectively. Since PA1624 is only present in an important human pathogen, its unique structure and periplasmic location render it a potential drug target. Consequently, the results presented here may open new avenues for the discovery and design of antibacterial drugs.
		+
		+	The hypothetical periplasmic protein PA1624 from Pseudomonas aeruginosa folds into a unique two-domain structure.,Feiler CG, Weiss MS, Blankenfeldt W Acta Crystallogr F Struct Biol Commun. 2020 Dec 1;76(Pt 12):609-615. doi:, 10.1107/S2053230X20014612. Epub 2020 Nov 30. PMID:33263573<ref>PMID:33263573</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6td9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Pseae]]
	[[Category: Blankenfeldt, W]]		[[Category: Blankenfeldt, W]]
	[[Category: Feiler, C G]]		[[Category: Feiler, C G]]

OCA at 08:18, 4 December 2019

OCA — Wed, 04 Dec 2019 08:18:28 GMT

←Older revision		Revision as of 08:18, 4 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6td9 is ~~ON HOLD until Paper Publication~~	+	==X-ray structure of mature PA1624 from Pseudomonas aeruginosa PAO1==
-		+	<StructureSection load='6td9' size='340' side='right'caption='[[6td9]], [[Resolution\|resolution]] 1.96Å' scene=''>
-	~~Authors~~: ~~Feiler~~, C.G., ~~Blankenfeldt~~, W.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6td9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TD9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TD9 FirstGlance]. <br>
-	~~Description~~: X-~~ray structure of mature PA1624 from Pseudomonas aeruginosa PAO1~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6td9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6td9 OCA], [http://pdbe.org/6td9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6td9 RCSB], [http://www.ebi.ac.uk/pdbsum/6td9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6td9 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Blankenfeldt, W]]		[[Category: Blankenfeldt, W]]
-	[[Category: Feiler, C.G]]	+	[[Category: Feiler, C G]]
		+	[[Category: Periplasmic protein]]
		+	[[Category: Unique fold]]
		+	[[Category: Unknown function]]

OCA: Protected "6td9" [edit=sysop:move=sysop]

OCA — Wed, 20 Nov 2019 13:36:43 GMT

Protected "6td9" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:36, 20 November 2019

OCA: New page: '''Unreleased structure''' The entry 6td9 is ON HOLD until Paper Publication Authors: Feiler, C.G., Blankenfeldt, W. Description: X-ray structure of mature PA1624 from Pseudomonas aeru...

OCA — Wed, 20 Nov 2019 13:36:41 GMT

New page: '''Unreleased structure''' The entry 6td9 is ON HOLD until Paper Publication Authors: Feiler, C.G., Blankenfeldt, W. Description: X-ray structure of mature PA1624 from Pseudomonas aeru...

New page

'''Unreleased structure'''

The entry 6td9 is ON HOLD until Paper Publication

Authors: Feiler, C.G., Blankenfeldt, W.

Description: X-ray structure of mature PA1624 from Pseudomonas aeruginosa PAO1
[[Category: Unreleased Structures]]
[[Category: Blankenfeldt, W]]
[[Category: Feiler, C.G]]